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Multicentric primary extramammary Paget disease: a Toker cell disorder?
Cutis 2014; 94(1):35-8C

Abstract

Toker cells are epithelial clear cells found in the areolar and nipple areas of the breast, vulvar region, and other apocrine gland-bearing areas of the skin. Toker cells have been implicated in the pathogenesis of clear cell papulosis, cutaneous hamartoma with pagetoid cells, and rare cases of primary extramammary Paget disease (EMPD) but not in secondary EMPD with underlying adenocarcinoma. The pathogenesis of primary EMPD is not well defined. We report a case of multicentric primary EMPD with evidence of Toker cell proliferation and nonaggressive biologic behavior in a 63-year-old white man. A detailed description of the morphologic and biologic features of Toker cells and their possible carcinogenetic links also are discussed. Based on the observation and follow-up of our patient, we hypothesize that multicentric primary EMPD starts with Toker cell hyperplasia and can potentially evolve to carcinoma in the genital region.

Authors+Show Affiliations

1901 1st Ave, New York, NY 10029, USA. panteahashemi@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25101342

Citation

Hashemi, Pantea, et al. "Multicentric Primary Extramammary Paget Disease: a Toker Cell Disorder?" Cutis, vol. 94, no. 1, 2014, pp. 35-8.
Hashemi P, Kao GF, Konia T, et al. Multicentric primary extramammary Paget disease: a Toker cell disorder? Cutis. 2014;94(1):35-8.
Hashemi, P., Kao, G. F., Konia, T., Kauffman, L. C., Tam, C. C., & Sina, B. (2014). Multicentric primary extramammary Paget disease: a Toker cell disorder? Cutis, 94(1), pp. 35-8.
Hashemi P, et al. Multicentric Primary Extramammary Paget Disease: a Toker Cell Disorder. Cutis. 2014;94(1):35-8. PubMed PMID: 25101342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multicentric primary extramammary Paget disease: a Toker cell disorder? AU - Hashemi,Pantea, AU - Kao,Grace F, AU - Konia,Thomas, AU - Kauffman,Lisa C, AU - Tam,Christine C, AU - Sina,Bahram, PY - 2014/8/8/entrez PY - 2014/8/8/pubmed PY - 2015/7/2/medline SP - 35 EP - 8 JF - Cutis JO - Cutis VL - 94 IS - 1 N2 - Toker cells are epithelial clear cells found in the areolar and nipple areas of the breast, vulvar region, and other apocrine gland-bearing areas of the skin. Toker cells have been implicated in the pathogenesis of clear cell papulosis, cutaneous hamartoma with pagetoid cells, and rare cases of primary extramammary Paget disease (EMPD) but not in secondary EMPD with underlying adenocarcinoma. The pathogenesis of primary EMPD is not well defined. We report a case of multicentric primary EMPD with evidence of Toker cell proliferation and nonaggressive biologic behavior in a 63-year-old white man. A detailed description of the morphologic and biologic features of Toker cells and their possible carcinogenetic links also are discussed. Based on the observation and follow-up of our patient, we hypothesize that multicentric primary EMPD starts with Toker cell hyperplasia and can potentially evolve to carcinoma in the genital region. SN - 2326-6929 UR - https://www.unboundmedicine.com/medline/citation/25101342/Multicentric_primary_extramammary_Paget_disease:_a_Toker_cell_disorder L2 - http://www.cutis.com/the-publication/past-issues-single-view/multicentric-primary-extramammary-paget-disease-a-toker-cell-disorder/09d11d7e0733df28cfcdf2e4933b1c41.html DB - PRIME DP - Unbound Medicine ER -