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Treatment of vitiligo with NB-UVB: A systematic review.
J Dermatolog Treat. 2015; 26(4):340-6.JD

Abstract

OBJECTIVE

To assess the effect and safety of NB-UVB for vitiligo using an evidence-based approach.

METHODS

Randomized controlled trials (RCTs) on the treatment of vitiligo with NB-UVB were identified by searching PubMed and the Cochrane Library. The primary outcome was re-pigmentation degree.

RESULTS

A total of seven RCTs involving 232 participants with vitiligo were included in this systematic review. The methodological qualities of included studies were generally moderate. Two trials compared narrow-band ultraviolet B (NB-UVB) with UVA control, showing no significant differences between two methods on the number of patients who achieved >60% re-pigmentation [relative risk (RR) = 2.50, 95% confidence interval (CI): 0.11-56.97, p > 0.05]. Two trials compared NB-UVB with psoralens plus UVA (PUVA) control, and no difference was seen between the two treatments on the number of patients who achieved >50 re-pigmentation (RR = 1.16, 95% CI: 0.64-2.11, p > 0.05) or >75% re-pigmentation (RR = 2.00, 95% CI: 0.89-4.48, p > 0.05). Three trials compared NB-UVB with 308-nm excimer light/laser (EL) control, and again no significant difference was found between the two methods (p > 0.05). The adverse events of NB-UVB in the included studies were slight and tolerated.

CONCLUSION

NB-UVB showed equivalent efficacies to UVA, PUVA or 308-nm EL control in the treatment of vitiligo. Side effects of NB-UVB were acceptable. More RCTs were needed to validate the results.

Authors+Show Affiliations

Department of Dermatology, No. 1 Hospital of China Medical University , Shenyang , China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25102894

Citation

Xiao, Bi-Huan, et al. "Treatment of Vitiligo With NB-UVB: a Systematic Review." The Journal of Dermatological Treatment, vol. 26, no. 4, 2015, pp. 340-6.
Xiao BH, Wu Y, Sun Y, et al. Treatment of vitiligo with NB-UVB: A systematic review. J Dermatolog Treat. 2015;26(4):340-6.
Xiao, B. H., Wu, Y., Sun, Y., Chen, H. D., & Gao, X. H. (2015). Treatment of vitiligo with NB-UVB: A systematic review. The Journal of Dermatological Treatment, 26(4), 340-6. https://doi.org/10.3109/09546634.2014.952610
Xiao BH, et al. Treatment of Vitiligo With NB-UVB: a Systematic Review. J Dermatolog Treat. 2015;26(4):340-6. PubMed PMID: 25102894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of vitiligo with NB-UVB: A systematic review. AU - Xiao,Bi-Huan, AU - Wu,Yan, AU - Sun,Yan, AU - Chen,Hong-Duo, AU - Gao,Xing-Hua, Y1 - 2014/08/26/ PY - 2014/8/9/entrez PY - 2014/8/12/pubmed PY - 2016/2/19/medline KW - Randomized controlled trials KW - UVB KW - vitiligo SP - 340 EP - 6 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 26 IS - 4 N2 - OBJECTIVE: To assess the effect and safety of NB-UVB for vitiligo using an evidence-based approach. METHODS: Randomized controlled trials (RCTs) on the treatment of vitiligo with NB-UVB were identified by searching PubMed and the Cochrane Library. The primary outcome was re-pigmentation degree. RESULTS: A total of seven RCTs involving 232 participants with vitiligo were included in this systematic review. The methodological qualities of included studies were generally moderate. Two trials compared narrow-band ultraviolet B (NB-UVB) with UVA control, showing no significant differences between two methods on the number of patients who achieved >60% re-pigmentation [relative risk (RR) = 2.50, 95% confidence interval (CI): 0.11-56.97, p > 0.05]. Two trials compared NB-UVB with psoralens plus UVA (PUVA) control, and no difference was seen between the two treatments on the number of patients who achieved >50 re-pigmentation (RR = 1.16, 95% CI: 0.64-2.11, p > 0.05) or >75% re-pigmentation (RR = 2.00, 95% CI: 0.89-4.48, p > 0.05). Three trials compared NB-UVB with 308-nm excimer light/laser (EL) control, and again no significant difference was found between the two methods (p > 0.05). The adverse events of NB-UVB in the included studies were slight and tolerated. CONCLUSION: NB-UVB showed equivalent efficacies to UVA, PUVA or 308-nm EL control in the treatment of vitiligo. Side effects of NB-UVB were acceptable. More RCTs were needed to validate the results. SN - 1471-1753 UR - https://www.unboundmedicine.com/medline/citation/25102894/Treatment_of_vitiligo_with_NB_UVB:_A_systematic_review_ L2 - http://www.tandfonline.com/doi/full/10.3109/09546634.2014.952610 DB - PRIME DP - Unbound Medicine ER -