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The expanding family Marseilleviridae.
Virology. 2014 Oct; 466-467:27-37.V

Abstract

The family Marseilleviridae encompasses giant viruses that replicate in free-living Acanthamoeba amoebae. Since the discovery of the founding member Marseillevirus in 2007, 7 new marseilleviruses have been observed, including 3 from environmental freshwater, one from a dipteran, and two from symptom-free humans. Marseilleviruses have ≈250-nm-large icosahedral capsids and 346-386-kb-long mosaic genomes that encode 444-497 predicted proteins. They share a small set of core genes with Mimivirus and other large and giant DNA viruses that compose a monophyletic group, first described in 2001. Comparative genomics analyses indicate that the family Marseilleviridae currently includes three lineages and a pan-genome composed of ≈600 genes. Antibodies against marseilleviruses and viral DNA have been observed in a significant proportion of asymptomatic individuals and in the blood and lymph nodes of a child with adenitis; these observations suggest that these giant viruses may be blood borne and question if they may be pathogenic in humans.

Authors+Show Affiliations

Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) UM63 CNRS 7278 IRD 198 INSERM U1095, Aix-Marseille Univ., 27 boulevard Jean Moulin, Faculté de Médecine, 13385 Marseille Cedex 05, France; Fondation Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) UM63 CNRS 7278 IRD 198 INSERM U1095, Aix-Marseille Univ., 27 boulevard Jean Moulin, Faculté de Médecine, 13385 Marseille Cedex 05, France; Fondation Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) UM63 CNRS 7278 IRD 198 INSERM U1095, Aix-Marseille Univ., 27 boulevard Jean Moulin, Faculté de Médecine, 13385 Marseille Cedex 05, France.Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) UM63 CNRS 7278 IRD 198 INSERM U1095, Aix-Marseille Univ., 27 boulevard Jean Moulin, Faculté de Médecine, 13385 Marseille Cedex 05, France; Fondation Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) UM63 CNRS 7278 IRD 198 INSERM U1095, Aix-Marseille Univ., 27 boulevard Jean Moulin, Faculté de Médecine, 13385 Marseille Cedex 05, France; Fondation Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France. Electronic address: philippe.colson@univ-amu.fr.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25104553

Citation

Aherfi, Sarah, et al. "The Expanding Family Marseilleviridae." Virology, vol. 466-467, 2014, pp. 27-37.
Aherfi S, La Scola B, Pagnier I, et al. The expanding family Marseilleviridae. Virology. 2014;466-467:27-37.
Aherfi, S., La Scola, B., Pagnier, I., Raoult, D., & Colson, P. (2014). The expanding family Marseilleviridae. Virology, 466-467, 27-37. https://doi.org/10.1016/j.virol.2014.07.014
Aherfi S, et al. The Expanding Family Marseilleviridae. Virology. 2014;466-467:27-37. PubMed PMID: 25104553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The expanding family Marseilleviridae. AU - Aherfi,Sarah, AU - La Scola,Bernard, AU - Pagnier,Isabelle, AU - Raoult,Didier, AU - Colson,Philippe, Y1 - 2014/08/05/ PY - 2014/05/15/received PY - 2014/06/24/revised PY - 2014/07/07/accepted PY - 2014/8/9/entrez PY - 2014/8/12/pubmed PY - 2015/3/11/medline KW - Amoeba KW - Giant virus KW - Human KW - Marseilleviridae KW - Marseillevirus KW - Megavirales KW - Nucleocytoplasmic large DNA viruses SP - 27 EP - 37 JF - Virology JO - Virology VL - 466-467 N2 - The family Marseilleviridae encompasses giant viruses that replicate in free-living Acanthamoeba amoebae. Since the discovery of the founding member Marseillevirus in 2007, 7 new marseilleviruses have been observed, including 3 from environmental freshwater, one from a dipteran, and two from symptom-free humans. Marseilleviruses have ≈250-nm-large icosahedral capsids and 346-386-kb-long mosaic genomes that encode 444-497 predicted proteins. They share a small set of core genes with Mimivirus and other large and giant DNA viruses that compose a monophyletic group, first described in 2001. Comparative genomics analyses indicate that the family Marseilleviridae currently includes three lineages and a pan-genome composed of ≈600 genes. Antibodies against marseilleviruses and viral DNA have been observed in a significant proportion of asymptomatic individuals and in the blood and lymph nodes of a child with adenitis; these observations suggest that these giant viruses may be blood borne and question if they may be pathogenic in humans. SN - 1096-0341 UR - https://www.unboundmedicine.com/medline/citation/25104553/The_expanding_family_Marseilleviridae_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(14)00320-1 DB - PRIME DP - Unbound Medicine ER -