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Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population.

Abstract

OBJECTIVE

The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the coronary atherosclerotic burden is low. We examined whether NMR-based lipoprotein particle profiles are associated with CAC, and compared them with standard lipid and lipid ratios in the Japanese general population.

METHODS AND RESULTS

We conducted a cross-sectional study in 851 men aged 40-79 years without cardiovascular diseases and lipid-lowering therapies. Adjusted odds ratios (ORs) (95% confidence intervals) for the top versus the bottom quartile of NMR-measured particle concentrations were 2.01 (1.24-3.23) for low-density lipoprotein (LDL-P), 1.04 (0.62-1.75) for high-density lipoprotein (HDL-P), 1.82 (1.13-2.95) for very-low-density lipoprotein (VLDL-P), and 1.92 (1.18-3.17) for LDL-P/HDL-P ratio. Similarly adjusted ORs of NMR-measured particle sizes were 0.59 (0.36-0.97) for LDL-P, 0.66 (0.40-1.10) for HDL-P, and 0.67 (0.40-1.12) for VLDL-P. The corresponding ORs were 1.82 (1.14-2.90) for total cholesterol (TC), 2.06 (1.28-3.30) for low-density lipoprotein cholesterol (LDL-C), 0.56 (0.34-0.91) for high-density lipoprotein cholesterol (HDL-C), 2.02 (1.24-3.29) for triglycerides, 2.08 (1.29-3.36) for non-high-density lipoprotein cholesterol (non-HDL-C), 2.27 (1.37-3.78) for TC/HDL-C ratio, and 1.73 (1.06-2.85) for LDL-C/HDL-C ratio. After mutual adjustment for total LDL-P concentration and TC/HDL-C ratio or non-HDL-C, LDL-P was no longer associated, whereas TC/HDL-C ratio remained significantly associated with CAC.

CONCLUSIONS

In community-based Japanese men, the overall association of CAC with NMR-measured lipoprotein indices is comparable, but not superior, to that with standard lipids.

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  • Authors+Show Affiliations

    ,

    Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan; Department of Public Health, Shiga University of Medical Science, Otsu, Japan; Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan. Electronic address: hisataka@belle.shiga-med.ac.jp.

    ,

    Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    ,

    Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan; Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.

    ,

    Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan; Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    ,

    Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan; Department of Medical Statistics, Faculty of Medicine, Toho University, Tokyo, Japan; Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan.

    ,

    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.

    ,

    Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan; Department of Public Health, Shiga University of Medical Science, Otsu, Japan.

    Source

    Atherosclerosis 236:2 2014 Oct pg 237-43

    MeSH

    Adult
    Aged
    Blood Glucose
    Calcinosis
    Comorbidity
    Coronary Artery Disease
    Cross-Sectional Studies
    Humans
    Hypertension
    Japan
    Lipids
    Lipoproteins
    Male
    Middle Aged
    Multidetector Computed Tomography
    Odds Ratio
    Particle Size
    Proton Magnetic Resonance Spectroscopy
    Risk Factors
    Smoking

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25105580

    Citation

    Hisamatsu, Takashi, et al. "Lipoprotein Particle Profiles Compared With Standard Lipids in Association With Coronary Artery Calcification in the General Japanese Population." Atherosclerosis, vol. 236, no. 2, 2014, pp. 237-43.
    Hisamatsu T, Fujiyoshi A, Miura K, et al. Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population. Atherosclerosis. 2014;236(2):237-43.
    Hisamatsu, T., Fujiyoshi, A., Miura, K., Ohkubo, T., Kadota, A., Kadowaki, S., ... Ueshima, H. (2014). Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population. Atherosclerosis, 236(2), pp. 237-43. doi:10.1016/j.atherosclerosis.2014.07.019.
    Hisamatsu T, et al. Lipoprotein Particle Profiles Compared With Standard Lipids in Association With Coronary Artery Calcification in the General Japanese Population. Atherosclerosis. 2014;236(2):237-43. PubMed PMID: 25105580.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population. AU - Hisamatsu,Takashi, AU - Fujiyoshi,Akira, AU - Miura,Katsuyuki, AU - Ohkubo,Takayoshi, AU - Kadota,Aya, AU - Kadowaki,Sayaka, AU - Kadowaki,Takashi, AU - Yamamoto,Takashi, AU - Miyagawa,Naoko, AU - Zaid,Maryam, AU - Torii,Sayuki, AU - Takashima,Naoyuki, AU - Murakami,Yoshitaka, AU - Okamura,Tomonori, AU - Horie,Minoru, AU - Ueshima,Hirotsugu, AU - ,, Y1 - 2014/07/25/ PY - 2014/04/15/received PY - 2014/07/15/revised PY - 2014/07/16/accepted PY - 2014/8/9/entrez PY - 2014/8/12/pubmed PY - 2015/7/3/medline KW - Coronary artery calcification KW - Epidemiology KW - Lipids KW - Lipoproteins SP - 237 EP - 43 JF - Atherosclerosis JO - Atherosclerosis VL - 236 IS - 2 N2 - OBJECTIVE: The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the coronary atherosclerotic burden is low. We examined whether NMR-based lipoprotein particle profiles are associated with CAC, and compared them with standard lipid and lipid ratios in the Japanese general population. METHODS AND RESULTS: We conducted a cross-sectional study in 851 men aged 40-79 years without cardiovascular diseases and lipid-lowering therapies. Adjusted odds ratios (ORs) (95% confidence intervals) for the top versus the bottom quartile of NMR-measured particle concentrations were 2.01 (1.24-3.23) for low-density lipoprotein (LDL-P), 1.04 (0.62-1.75) for high-density lipoprotein (HDL-P), 1.82 (1.13-2.95) for very-low-density lipoprotein (VLDL-P), and 1.92 (1.18-3.17) for LDL-P/HDL-P ratio. Similarly adjusted ORs of NMR-measured particle sizes were 0.59 (0.36-0.97) for LDL-P, 0.66 (0.40-1.10) for HDL-P, and 0.67 (0.40-1.12) for VLDL-P. The corresponding ORs were 1.82 (1.14-2.90) for total cholesterol (TC), 2.06 (1.28-3.30) for low-density lipoprotein cholesterol (LDL-C), 0.56 (0.34-0.91) for high-density lipoprotein cholesterol (HDL-C), 2.02 (1.24-3.29) for triglycerides, 2.08 (1.29-3.36) for non-high-density lipoprotein cholesterol (non-HDL-C), 2.27 (1.37-3.78) for TC/HDL-C ratio, and 1.73 (1.06-2.85) for LDL-C/HDL-C ratio. After mutual adjustment for total LDL-P concentration and TC/HDL-C ratio or non-HDL-C, LDL-P was no longer associated, whereas TC/HDL-C ratio remained significantly associated with CAC. CONCLUSIONS: In community-based Japanese men, the overall association of CAC with NMR-measured lipoprotein indices is comparable, but not superior, to that with standard lipids. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/25105580/Lipoprotein_particle_profiles_compared_with_standard_lipids_in_association_with_coronary_artery_calcification_in_the_general_Japanese_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(14)01295-7 DB - PRIME DP - Unbound Medicine ER -