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Systems pharmacology-based approach for dissecting the addition and subtraction theory of traditional Chinese medicine: An example using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction.
Comput Biol Med 2014; 53:19-29CB

Abstract

BACKGROUND

Addition and subtraction theory (AST), a basic theory of herb combination in traditional Chinese medicine (TCM), is often used to add or subtract the "fundamental formulae" to generate more targeted prescriptions. This theory plays a core role in individualized medicine and compound compatibility of TCM. However, the mechanisms underlying AST have largely remained elusive.

METHODS

An integrated platform of systems pharmacology was proposed for revealing how the oral administration, drug half-life, and target interactions affect the pharmacological functions of herbal medicines. This platform was further applied on two classical prescriptions, i.e., Xiao Chaihu decoction (XCHD) and Da Chaihu decoction (DCHD) to dissect the addition and subtraction theory (AST).

RESULTS

We uncovered the candidate compounds, key molecular targets and interaction network involved in XCHD and DCHD, and summarized its pharmacological characters and therapeutic indications. The results show that the "fundamental formula" is responsible for the major therapeutic effects, whereas the "additive herbs" synergistically enhance the treatment outcomes by targeting the same or complementary proteins between the foundational and additive herbs.

CONCLUSION

This work has established a novel method to comprehensively understand the mechanism of AST, which would be beneficial for the TCM recipe optimization as well as the production of new herbal formula with desirable therapeutic effects.

Authors+Show Affiliations

College of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China; Lab of Systems Pharmacology, Bioinformatics Center, Northwest A&F University, China.College of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China; Lab of Systems Pharmacology, Bioinformatics Center, Northwest A&F University, China.College of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China; Lab of Systems Pharmacology, Bioinformatics Center, Northwest A&F University, China.Lab of Systems Pharmacology, Bioinformatics Center, Northwest A&F University, China; College of International, Northwest A&F University, Yangling, Shaanxi, China.College of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China; Lab of Systems Pharmacology, Bioinformatics Center, Northwest A&F University, China.College of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China; Lab of Systems Pharmacology, Bioinformatics Center, Northwest A&F University, China.College of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China; Lab of Systems Pharmacology, Bioinformatics Center, Northwest A&F University, China. Electronic address: yh_wang@nwsuaf.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25105750

Citation

Li, Bohui, et al. "Systems Pharmacology-based Approach for Dissecting the Addition and Subtraction Theory of Traditional Chinese Medicine: an Example Using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction." Computers in Biology and Medicine, vol. 53, 2014, pp. 19-29.
Li B, Tao W, Zheng C, et al. Systems pharmacology-based approach for dissecting the addition and subtraction theory of traditional Chinese medicine: An example using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction. Comput Biol Med. 2014;53:19-29.
Li, B., Tao, W., Zheng, C., Shar, P. A., Huang, C., Fu, Y., & Wang, Y. (2014). Systems pharmacology-based approach for dissecting the addition and subtraction theory of traditional Chinese medicine: An example using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction. Computers in Biology and Medicine, 53, pp. 19-29. doi:10.1016/j.compbiomed.2014.05.007.
Li B, et al. Systems Pharmacology-based Approach for Dissecting the Addition and Subtraction Theory of Traditional Chinese Medicine: an Example Using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction. Comput Biol Med. 2014;53:19-29. PubMed PMID: 25105750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systems pharmacology-based approach for dissecting the addition and subtraction theory of traditional Chinese medicine: An example using Xiao-Chaihu-Decoction and Da-Chaihu-Decoction. AU - Li,Bohui, AU - Tao,Weiyang, AU - Zheng,Chunli, AU - Shar,Piar Ali, AU - Huang,Chao, AU - Fu,Yingxue, AU - Wang,Yonghua, Y1 - 2014/05/28/ PY - 2014/01/28/received PY - 2014/05/09/revised PY - 2014/05/19/accepted PY - 2014/8/9/entrez PY - 2014/8/12/pubmed PY - 2015/6/3/medline KW - Addition and subtraction theory KW - Da chaihu decoction KW - Systems pharmacology KW - Traditional Chinese medicine KW - Xiao chaihu decoction SP - 19 EP - 29 JF - Computers in biology and medicine JO - Comput. Biol. Med. VL - 53 N2 - BACKGROUND: Addition and subtraction theory (AST), a basic theory of herb combination in traditional Chinese medicine (TCM), is often used to add or subtract the "fundamental formulae" to generate more targeted prescriptions. This theory plays a core role in individualized medicine and compound compatibility of TCM. However, the mechanisms underlying AST have largely remained elusive. METHODS: An integrated platform of systems pharmacology was proposed for revealing how the oral administration, drug half-life, and target interactions affect the pharmacological functions of herbal medicines. This platform was further applied on two classical prescriptions, i.e., Xiao Chaihu decoction (XCHD) and Da Chaihu decoction (DCHD) to dissect the addition and subtraction theory (AST). RESULTS: We uncovered the candidate compounds, key molecular targets and interaction network involved in XCHD and DCHD, and summarized its pharmacological characters and therapeutic indications. The results show that the "fundamental formula" is responsible for the major therapeutic effects, whereas the "additive herbs" synergistically enhance the treatment outcomes by targeting the same or complementary proteins between the foundational and additive herbs. CONCLUSION: This work has established a novel method to comprehensively understand the mechanism of AST, which would be beneficial for the TCM recipe optimization as well as the production of new herbal formula with desirable therapeutic effects. SN - 1879-0534 UR - https://www.unboundmedicine.com/medline/citation/25105750/Systems_pharmacology_based_approach_for_dissecting_the_addition_and_subtraction_theory_of_traditional_Chinese_medicine:_An_example_using_Xiao_Chaihu_Decoction_and_Da_Chaihu_Decoction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-4825(14)00122-X DB - PRIME DP - Unbound Medicine ER -