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Prescription opioid misuse and mental health among young injection drug users.
Am J Drug Alcohol Abuse. 2015 Jan; 41(1):100-6.AJ

Abstract

BACKGROUND

Prescription opioid (PO) misuse is a significant concern in the United States.

OBJECTIVES

This study describes the prevalence and timing of PO misuse, diagnoses of opiate abuse and dependence, and their associations with psychiatric disorders in a sample of young people who inject drugs (PWID).

METHODS

Participants were 570 young (18-25 years) PWID, primarily heroin users, recruited through outreach and respondent-driven sampling. Trained interviewers administered a semi-structured psychiatric interview. Diagnoses of substance use and mental disorders were based on DSM-IV diagnostic criteria.

RESULTS

Estimated rates of lifetime PO abuse and dependence were 19% and 17%, respectively. Past year PO misuse was significantly associated with anti-social personality disorder (ASPD, OR = 2.15, 95% CI 1.43-3.24), past year substance-induced major depression (SIMD, OR = 1.81, 95% CI 1.16-2.83), and prior post-traumatic stress disorder (PTSD, OR = 2.45, 95% CI 1.31-4.60). Among male PO users, PTSD was a significant predictor of PO abuse (prior, OR = 7.62, 95% CI 2.16-26.88; past year, OR = 21.67 95% CI 2.46-190.75), and dependence (prior, OR = 4.82, 95% CI 1.48-15.67; past year, OR = 9.65, 95% CI 1.75-53.32).

CONCLUSION

Among young PWID, PTSD is a significant risk factor for PO misuse for both men and women, and men with PTSD are in addition at increased risk for PO abuse and dependence. These findings have implications for harm reduction and substance abuse prevention efforts.

Authors+Show Affiliations

Community Outreach Intervention Projects, Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago , Chicago, IL , USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25105884

Citation

Mackesy-Amiti, Mary E., et al. "Prescription Opioid Misuse and Mental Health Among Young Injection Drug Users." The American Journal of Drug and Alcohol Abuse, vol. 41, no. 1, 2015, pp. 100-6.
Mackesy-Amiti ME, Donenberg GR, Ouellet LJ. Prescription opioid misuse and mental health among young injection drug users. Am J Drug Alcohol Abuse. 2015;41(1):100-6.
Mackesy-Amiti, M. E., Donenberg, G. R., & Ouellet, L. J. (2015). Prescription opioid misuse and mental health among young injection drug users. The American Journal of Drug and Alcohol Abuse, 41(1), 100-6. https://doi.org/10.3109/00952990.2014.940424
Mackesy-Amiti ME, Donenberg GR, Ouellet LJ. Prescription Opioid Misuse and Mental Health Among Young Injection Drug Users. Am J Drug Alcohol Abuse. 2015;41(1):100-6. PubMed PMID: 25105884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prescription opioid misuse and mental health among young injection drug users. AU - Mackesy-Amiti,Mary E, AU - Donenberg,Geri R, AU - Ouellet,Lawrence J, Y1 - 2014/08/08/ PY - 2014/8/9/entrez PY - 2014/8/12/pubmed PY - 2015/7/15/medline KW - Heroin KW - injection drug use KW - mental health KW - prescription opioids SP - 100 EP - 6 JF - The American journal of drug and alcohol abuse JO - Am J Drug Alcohol Abuse VL - 41 IS - 1 N2 - BACKGROUND: Prescription opioid (PO) misuse is a significant concern in the United States. OBJECTIVES: This study describes the prevalence and timing of PO misuse, diagnoses of opiate abuse and dependence, and their associations with psychiatric disorders in a sample of young people who inject drugs (PWID). METHODS: Participants were 570 young (18-25 years) PWID, primarily heroin users, recruited through outreach and respondent-driven sampling. Trained interviewers administered a semi-structured psychiatric interview. Diagnoses of substance use and mental disorders were based on DSM-IV diagnostic criteria. RESULTS: Estimated rates of lifetime PO abuse and dependence were 19% and 17%, respectively. Past year PO misuse was significantly associated with anti-social personality disorder (ASPD, OR = 2.15, 95% CI 1.43-3.24), past year substance-induced major depression (SIMD, OR = 1.81, 95% CI 1.16-2.83), and prior post-traumatic stress disorder (PTSD, OR = 2.45, 95% CI 1.31-4.60). Among male PO users, PTSD was a significant predictor of PO abuse (prior, OR = 7.62, 95% CI 2.16-26.88; past year, OR = 21.67 95% CI 2.46-190.75), and dependence (prior, OR = 4.82, 95% CI 1.48-15.67; past year, OR = 9.65, 95% CI 1.75-53.32). CONCLUSION: Among young PWID, PTSD is a significant risk factor for PO misuse for both men and women, and men with PTSD are in addition at increased risk for PO abuse and dependence. These findings have implications for harm reduction and substance abuse prevention efforts. SN - 1097-9891 UR - https://www.unboundmedicine.com/medline/citation/25105884/Prescription_opioid_misuse_and_mental_health_among_young_injection_drug_users_ L2 - https://www.tandfonline.com/doi/full/10.3109/00952990.2014.940424 DB - PRIME DP - Unbound Medicine ER -