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Serum levels of trace minerals and heavy metals in severe obstructive sleep apnea patients: correlates and clinical implications.
Sleep Breath 2015; 19(2):547-52SB

Abstract

PURPOSE

The aim of the present study was to evaluate the serum levels of trace minerals and heavy metals in obstructive sleep apnea (OSA) patients and to investigate whether there is a correlation between levels of trace minerals and demographic and biochemical variables.

METHODS

This clinical, case-control study was performed on 61 OSA patients and 36 healthy controls. Demographic, radiological, biochemical variables, as well as serum levels of trace minerals (magnesium, copper, iron, zinc, manganese, cobalt) and heavy metals (lead, cadmium) were compared in OSA and control groups. In addition, correlation of serum levels of these substances to demographic, biochemical, and radiological parameters was tested.

RESULTS

Not only serum levels of cholesterol, triglycerides, cadmium, cobalt, copper, iron, magnesium, manganese, lead, and zinc were found to be higher, but also carotid intima-media thickness (CIMT) was increased in OSA patients. Increase in CIMT was found to be correlated with levels of cobalt, copper, iron, magnesium, manganese, and zinc.

CONCLUSION

Our results have shown that serum levels of trace minerals and heavy metals were higher in OSA. This difference may ensource from deterioration of the balance of these substances due to oxidative stress and inflammation. Significance of these findings with respect to the etiopathogenesis, diagnosis, and treatment of OSA warrants further trials.

Authors+Show Affiliations

Department of Chest Diseases, Van Training and Research Hospital, Van Yuzuncu Yil University Medical Faculty, 65100, Van, Turkey, selviasker@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25107374

Citation

Asker, Selvi, et al. "Serum Levels of Trace Minerals and Heavy Metals in Severe Obstructive Sleep Apnea Patients: Correlates and Clinical Implications." Sleep & Breathing = Schlaf & Atmung, vol. 19, no. 2, 2015, pp. 547-52.
Asker S, Asker M, Yeltekin AC, et al. Serum levels of trace minerals and heavy metals in severe obstructive sleep apnea patients: correlates and clinical implications. Sleep Breath. 2015;19(2):547-52.
Asker, S., Asker, M., Yeltekin, A. C., Aslan, M., & Demir, H. (2015). Serum levels of trace minerals and heavy metals in severe obstructive sleep apnea patients: correlates and clinical implications. Sleep & Breathing = Schlaf & Atmung, 19(2), pp. 547-52. doi:10.1007/s11325-014-1045-2.
Asker S, et al. Serum Levels of Trace Minerals and Heavy Metals in Severe Obstructive Sleep Apnea Patients: Correlates and Clinical Implications. Sleep Breath. 2015;19(2):547-52. PubMed PMID: 25107374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of trace minerals and heavy metals in severe obstructive sleep apnea patients: correlates and clinical implications. AU - Asker,Selvi, AU - Asker,Muntecep, AU - Yeltekin,Asli Cilingir, AU - Aslan,Mehmet, AU - Demir,Halit, Y1 - 2014/08/09/ PY - 2014/03/13/received PY - 2014/07/30/accepted PY - 2014/07/23/revised PY - 2014/8/10/entrez PY - 2014/8/12/pubmed PY - 2016/4/8/medline SP - 547 EP - 52 JF - Sleep & breathing = Schlaf & Atmung JO - Sleep Breath VL - 19 IS - 2 N2 - PURPOSE: The aim of the present study was to evaluate the serum levels of trace minerals and heavy metals in obstructive sleep apnea (OSA) patients and to investigate whether there is a correlation between levels of trace minerals and demographic and biochemical variables. METHODS: This clinical, case-control study was performed on 61 OSA patients and 36 healthy controls. Demographic, radiological, biochemical variables, as well as serum levels of trace minerals (magnesium, copper, iron, zinc, manganese, cobalt) and heavy metals (lead, cadmium) were compared in OSA and control groups. In addition, correlation of serum levels of these substances to demographic, biochemical, and radiological parameters was tested. RESULTS: Not only serum levels of cholesterol, triglycerides, cadmium, cobalt, copper, iron, magnesium, manganese, lead, and zinc were found to be higher, but also carotid intima-media thickness (CIMT) was increased in OSA patients. Increase in CIMT was found to be correlated with levels of cobalt, copper, iron, magnesium, manganese, and zinc. CONCLUSION: Our results have shown that serum levels of trace minerals and heavy metals were higher in OSA. This difference may ensource from deterioration of the balance of these substances due to oxidative stress and inflammation. Significance of these findings with respect to the etiopathogenesis, diagnosis, and treatment of OSA warrants further trials. SN - 1522-1709 UR - https://www.unboundmedicine.com/medline/citation/25107374/Serum_levels_of_trace_minerals_and_heavy_metals_in_severe_obstructive_sleep_apnea_patients:_correlates_and_clinical_implications_ L2 - https://dx.doi.org/10.1007/s11325-014-1045-2 DB - PRIME DP - Unbound Medicine ER -