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A prospective, observational, epidemiological evaluation of the aetiology and antimicrobial susceptibility of acute otitis media in Saudi children younger than 5years of age.
J Epidemiol Glob Health 2014; 4(3):231-8JE

Abstract

BACKGROUND

Information regarding acute otitis media (AOM) aetiology is important for developing effective vaccines. Here, bacterial aetiology and antimicrobial susceptibility of AOM were determined in young Saudi children.

METHODS

Children aged 3-60months with a new episode of AOM, who had not received antibiotics or had received antibiotics for 48-72h but remained symptomatic, were enrolled in this prospective, observational, epidemiological study in Riyadh. Middle ear fluid (MEF) samples were collected by tympanocentesis or from spontaneous otorrhea, and tested for the presence of Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus pyogenes and Moraxella catarrhalis. Antimicrobial susceptibility of the identified pathogens was assessed using E-tests.

RESULTS

Between June 2009 and May 2011, 66 children were enrolled. S. pneumoniae was detected in 6 episodes and non-typeable H. influenzae (NTHi) in 8 episodes. Moreover, Staphylococcus aureus, which is an uncommon cause of AOM, was detected in 17 episodes. Pneumococcal serotypes were 7F (n=2), 23F (n=2), 19F (n=1) and 15F (n=1). Susceptibility to cefotaxime was observed in all pneumococcal and H. influenzae isolates, to cefuroxime in 4/6 pneumococcal and 8/8 H. influenzae isolates, and to penicillin in 5/6 pneumococcal isolates.

CONCLUSIONS

S. pneumoniae and NTHi were major bacterial contributors for AOM in Saudi children.

Authors+Show Affiliations

King Saud University and King Saud bin Abdulaziz University for Health Sciences, PO Box 86118, Riyadh, Saudi Arabia. Electronic address: kalmazrou@gmail.com.King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia. Electronic address: amshibl@ksu.edu.sa.GlaxoSmithKline Vaccines, Avenue Fleming 20, 1300 Wavre, Belgium. Electronic address: walid.x.kandeil@gsk.com.GlaxoSmithKline Vaccines, Avenue Fleming 20, 1300 Wavre, Belgium. Electronic address: jean-yves.x.pircon@gsk.com.GlaxoSmithKline Vaccines, Avenue Fleming 20, 1300 Wavre, Belgium. Electronic address: cinzia.x.marano@gsk.com.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25107659

Citation

Al-Mazrou, Khalid A., et al. "A Prospective, Observational, Epidemiological Evaluation of the Aetiology and Antimicrobial Susceptibility of Acute Otitis Media in Saudi Children Younger Than 5years of Age." Journal of Epidemiology and Global Health, vol. 4, no. 3, 2014, pp. 231-8.
Al-Mazrou KA, Shibl AM, Kandeil W, et al. A prospective, observational, epidemiological evaluation of the aetiology and antimicrobial susceptibility of acute otitis media in Saudi children younger than 5years of age. J Epidemiol Glob Health. 2014;4(3):231-8.
Al-Mazrou, K. A., Shibl, A. M., Kandeil, W., Pirçon, J. Y., & Marano, C. (2014). A prospective, observational, epidemiological evaluation of the aetiology and antimicrobial susceptibility of acute otitis media in Saudi children younger than 5years of age. Journal of Epidemiology and Global Health, 4(3), pp. 231-8. doi:10.1016/j.jegh.2014.03.002.
Al-Mazrou KA, et al. A Prospective, Observational, Epidemiological Evaluation of the Aetiology and Antimicrobial Susceptibility of Acute Otitis Media in Saudi Children Younger Than 5years of Age. J Epidemiol Glob Health. 2014;4(3):231-8. PubMed PMID: 25107659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective, observational, epidemiological evaluation of the aetiology and antimicrobial susceptibility of acute otitis media in Saudi children younger than 5years of age. AU - Al-Mazrou,Khalid A, AU - Shibl,Atef M, AU - Kandeil,Walid, AU - Pirçon,Jean-Yves, AU - Marano,Cinzia, Y1 - 2014/04/21/ PY - 2013/11/28/received PY - 2014/02/28/revised PY - 2014/03/15/accepted PY - 2014/8/10/entrez PY - 2014/8/12/pubmed PY - 2015/5/12/medline KW - Acute otitis media KW - Antibiotic resistance KW - Child KW - Haemophilus influenzae KW - Saudi Arabia KW - Streptococcus pneumoniae SP - 231 EP - 8 JF - Journal of epidemiology and global health JO - J Epidemiol Glob Health VL - 4 IS - 3 N2 - BACKGROUND: Information regarding acute otitis media (AOM) aetiology is important for developing effective vaccines. Here, bacterial aetiology and antimicrobial susceptibility of AOM were determined in young Saudi children. METHODS: Children aged 3-60months with a new episode of AOM, who had not received antibiotics or had received antibiotics for 48-72h but remained symptomatic, were enrolled in this prospective, observational, epidemiological study in Riyadh. Middle ear fluid (MEF) samples were collected by tympanocentesis or from spontaneous otorrhea, and tested for the presence of Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus pyogenes and Moraxella catarrhalis. Antimicrobial susceptibility of the identified pathogens was assessed using E-tests. RESULTS: Between June 2009 and May 2011, 66 children were enrolled. S. pneumoniae was detected in 6 episodes and non-typeable H. influenzae (NTHi) in 8 episodes. Moreover, Staphylococcus aureus, which is an uncommon cause of AOM, was detected in 17 episodes. Pneumococcal serotypes were 7F (n=2), 23F (n=2), 19F (n=1) and 15F (n=1). Susceptibility to cefotaxime was observed in all pneumococcal and H. influenzae isolates, to cefuroxime in 4/6 pneumococcal and 8/8 H. influenzae isolates, and to penicillin in 5/6 pneumococcal isolates. CONCLUSIONS: S. pneumoniae and NTHi were major bacterial contributors for AOM in Saudi children. SN - 2210-6014 UR - https://www.unboundmedicine.com/medline/citation/25107659/A_prospective_observational_epidemiological_evaluation_of_the_aetiology_and_antimicrobial_susceptibility_of_acute_otitis_media_in_Saudi_children_younger_than_5years_of_age_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2210-6006(14)00023-9 DB - PRIME DP - Unbound Medicine ER -