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The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men.
Age (Dordr). 2014; 36(4):9699.A

Abstract

Skeletal muscle satellite cells (SCs) have been shown to be instrumental in the muscle adaptive response to exercise. The present study determines age-related differences in SC content and activation status following a single bout of exercise. Ten young (22 ± 1 years) and 10 elderly (73 ± 1 years) men performed a single bout of resistance-type exercise. Muscle biopsies were collected before and 12, 24, 48, and 72 h after exercise. SC content and activation status were assessed in type I and type II muscle fibers by immunohistochemistry. Myostatin and MyoD protein and messenger RNA (mRNA) expression were determined by Western blotting and rtPCR, respectively. In response to exercise, it took 48 h (young) and 72 h (elderly) for type II muscle fiber SC content to exceed baseline values (P < 0.01). The number of myostatin + SC in type I and II muscle fibers was significantly reduced after 12, 24, and 48 h of post-exercise recovery in both groups (P < 0.01), with a greater reduction observed at 24 and 48 h in the young compared with that in the elderly men (P < 0.01). In conclusion, the increase in type II muscle fiber SC content during post-exercise recovery is delayed with aging and is accompanied by a blunted SC activation response.

Authors+Show Affiliations

Department of Human Movement Sciences, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25108351

Citation

Snijders, Tim, et al. "The Skeletal Muscle Satellite Cell Response to a Single Bout of Resistance-type Exercise Is Delayed With Aging in Men." Age (Dordrecht, Netherlands), vol. 36, no. 4, 2014, p. 9699.
Snijders T, Verdijk LB, Smeets JS, et al. The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men. Age (Dordr). 2014;36(4):9699.
Snijders, T., Verdijk, L. B., Smeets, J. S., McKay, B. R., Senden, J. M., Hartgens, F., Parise, G., Greenhaff, P., & van Loon, L. J. (2014). The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men. Age (Dordrecht, Netherlands), 36(4), 9699. https://doi.org/10.1007/s11357-014-9699-z
Snijders T, et al. The Skeletal Muscle Satellite Cell Response to a Single Bout of Resistance-type Exercise Is Delayed With Aging in Men. Age (Dordr). 2014;36(4):9699. PubMed PMID: 25108351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men. AU - Snijders,Tim, AU - Verdijk,Lex B, AU - Smeets,Joey S J, AU - McKay,Bryon R, AU - Senden,Joan M G, AU - Hartgens,Fred, AU - Parise,Gianni, AU - Greenhaff,Paul, AU - van Loon,Luc J C, Y1 - 2014/08/10/ PY - 2014/02/21/received PY - 2014/07/30/accepted PY - 2014/8/11/entrez PY - 2014/8/12/pubmed PY - 2015/4/1/medline SP - 9699 EP - 9699 JF - Age (Dordrecht, Netherlands) JO - Age (Dordr) VL - 36 IS - 4 N2 - Skeletal muscle satellite cells (SCs) have been shown to be instrumental in the muscle adaptive response to exercise. The present study determines age-related differences in SC content and activation status following a single bout of exercise. Ten young (22 ± 1 years) and 10 elderly (73 ± 1 years) men performed a single bout of resistance-type exercise. Muscle biopsies were collected before and 12, 24, 48, and 72 h after exercise. SC content and activation status were assessed in type I and type II muscle fibers by immunohistochemistry. Myostatin and MyoD protein and messenger RNA (mRNA) expression were determined by Western blotting and rtPCR, respectively. In response to exercise, it took 48 h (young) and 72 h (elderly) for type II muscle fiber SC content to exceed baseline values (P < 0.01). The number of myostatin + SC in type I and II muscle fibers was significantly reduced after 12, 24, and 48 h of post-exercise recovery in both groups (P < 0.01), with a greater reduction observed at 24 and 48 h in the young compared with that in the elderly men (P < 0.01). In conclusion, the increase in type II muscle fiber SC content during post-exercise recovery is delayed with aging and is accompanied by a blunted SC activation response. SN - 1574-4647 UR - https://www.unboundmedicine.com/medline/citation/25108351/The_skeletal_muscle_satellite_cell_response_to_a_single_bout_of_resistance_type_exercise_is_delayed_with_aging_in_men_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25108351/ DB - PRIME DP - Unbound Medicine ER -