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Associations between Omega-3 Index increase and triacylglyceride decrease in subjects with hypertriglyceridemia in response to six month of EPA and DHA supplementation.
Prostaglandins Leukot Essent Fatty Acids. 2014 Oct; 91(4):129-34.PL

Abstract

INTRODUCTION

Ingestion of long-chain n-3 PUFA effectively decreases serum triacylglycerol (TAG) levels and increases the Omega-3 Index, defined as the % of EPA and DHA in erythrocyte fatty acids. However, it remains unclear whether there is a relationship between the Omega-3 Index increase (ΔO3I increase) and the TAG level decrease (ΔTAG). We hypothesized that TAG reduction is strongly depended on Omega-3 Index increase.

SUBJECTS AND METHODS

Secondary analyses of data from a former double-blind placebo-controlled trial in which 150 dyslipidemic statin-treated subjects were randomized to four capsules of fish oil daily either as re-esterified TAG or ethyl esters in identical doses (1.01 g EPA+0.67 g DHA) or corn oil as a placebo for a period of six month.

RESULTS

108 subjects fulfilled the criteria of the current study protocol and were included in the analyses. A weak but significant negative correlation between ΔO3I and ΔTAG was observed (r=-0.211, p<0.05). However, the relation between ΔO3I and serum ΔTAG was not linear (coefficients of determination R(2): 0.044). After sub-grouping the study population into Omega-3 Index response groups, the group with a mean ΔO3I of>4% after six months of n-3 PUFA treatment demonstrated the greatest TAG reduction.

DISCUSSION AND CONCLUSIONS

A weak association between Omega-3 Index increase and TAG level decrease was found. This may be explained by highly fluctuating TAG levels, a large inter-individual difference in response of the Omega-3 Index, a cohort of subjects with only slightly elevated TAG levels and high Omega-3 Index values at baseline, and possibly to insufficient statistical power. Since there was no strong association between Omega-3 Index increase and the TAG level decrease, we conclude that changes in serum TAG levels are not a viable substitute for the Omega-3 Index to monitor treatment with EPA and DHA.

Authors+Show Affiliations

Institute of Food Science and Human Nutrition, Leibniz University Hannover, Germany. Electronic address: schuchardt@nutrition.uni-hannover.de.Institute of Food Science and Human Nutrition, Leibniz University Hannover, Germany.Department of Public Health Sciences and the Cardiology Division, Department of Medicine, the University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.PreventiveCardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians University Munich, Germany.Institute of Food Science and Human Nutrition, Leibniz University Hannover, Germany.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25108576

Citation

Schuchardt, Jan Philipp, et al. "Associations Between Omega-3 Index Increase and Triacylglyceride Decrease in Subjects With Hypertriglyceridemia in Response to Six Month of EPA and DHA Supplementation." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 91, no. 4, 2014, pp. 129-34.
Schuchardt JP, Neubronner J, Block RC, et al. Associations between Omega-3 Index increase and triacylglyceride decrease in subjects with hypertriglyceridemia in response to six month of EPA and DHA supplementation. Prostaglandins Leukot Essent Fatty Acids. 2014;91(4):129-34.
Schuchardt, J. P., Neubronner, J., Block, R. C., von Schacky, C., & Hahn, A. (2014). Associations between Omega-3 Index increase and triacylglyceride decrease in subjects with hypertriglyceridemia in response to six month of EPA and DHA supplementation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 91(4), 129-34. https://doi.org/10.1016/j.plefa.2014.07.014
Schuchardt JP, et al. Associations Between Omega-3 Index Increase and Triacylglyceride Decrease in Subjects With Hypertriglyceridemia in Response to Six Month of EPA and DHA Supplementation. Prostaglandins Leukot Essent Fatty Acids. 2014;91(4):129-34. PubMed PMID: 25108576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between Omega-3 Index increase and triacylglyceride decrease in subjects with hypertriglyceridemia in response to six month of EPA and DHA supplementation. AU - Schuchardt,Jan Philipp, AU - Neubronner,Juliane, AU - Block,Robert C, AU - von Schacky,Clemens, AU - Hahn,Andreas, Y1 - 2014/07/23/ PY - 2014/05/26/received PY - 2014/07/14/revised PY - 2014/07/15/accepted PY - 2014/8/11/entrez PY - 2014/8/12/pubmed PY - 2015/7/16/medline KW - Hypertriglyceridemia KW - Omega-3 Index KW - Triacylglycerides SP - 129 EP - 34 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 91 IS - 4 N2 - INTRODUCTION: Ingestion of long-chain n-3 PUFA effectively decreases serum triacylglycerol (TAG) levels and increases the Omega-3 Index, defined as the % of EPA and DHA in erythrocyte fatty acids. However, it remains unclear whether there is a relationship between the Omega-3 Index increase (ΔO3I increase) and the TAG level decrease (ΔTAG). We hypothesized that TAG reduction is strongly depended on Omega-3 Index increase. SUBJECTS AND METHODS: Secondary analyses of data from a former double-blind placebo-controlled trial in which 150 dyslipidemic statin-treated subjects were randomized to four capsules of fish oil daily either as re-esterified TAG or ethyl esters in identical doses (1.01 g EPA+0.67 g DHA) or corn oil as a placebo for a period of six month. RESULTS: 108 subjects fulfilled the criteria of the current study protocol and were included in the analyses. A weak but significant negative correlation between ΔO3I and ΔTAG was observed (r=-0.211, p<0.05). However, the relation between ΔO3I and serum ΔTAG was not linear (coefficients of determination R(2): 0.044). After sub-grouping the study population into Omega-3 Index response groups, the group with a mean ΔO3I of>4% after six months of n-3 PUFA treatment demonstrated the greatest TAG reduction. DISCUSSION AND CONCLUSIONS: A weak association between Omega-3 Index increase and TAG level decrease was found. This may be explained by highly fluctuating TAG levels, a large inter-individual difference in response of the Omega-3 Index, a cohort of subjects with only slightly elevated TAG levels and high Omega-3 Index values at baseline, and possibly to insufficient statistical power. Since there was no strong association between Omega-3 Index increase and the TAG level decrease, we conclude that changes in serum TAG levels are not a viable substitute for the Omega-3 Index to monitor treatment with EPA and DHA. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/25108576/Associations_between_Omega_3_Index_increase_and_triacylglyceride_decrease_in_subjects_with_hypertriglyceridemia_in_response_to_six_month_of_EPA_and_DHA_supplementation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(14)00112-4 DB - PRIME DP - Unbound Medicine ER -