Tags

Type your tag names separated by a space and hit enter

Systematic review: the effect of prunes on gastrointestinal function.
Aliment Pharmacol Ther. 2014 Oct; 40(7):750-8.AP

Abstract

BACKGROUND

Prunes (dried plums) are high in fibre and are perceived to promote healthy gastrointestinal (GI) function.

AIM

To assess the effect of prunes on GI function through a systematic review of randomised controlled trials (RCTs).

METHODS

Sixteen electronic databases were searched, a hand search was performed and key opinion leaders were contacted. RCTs investigating the effect of prunes on GI function were included. Two reviewers independently screened relevant articles, extracted data and assessed risk of bias.

RESULTS

Four trials met the inclusion criteria, one in constipation and three in non-constipated subjects. In constipation, 3 weeks of prune consumption (100 g/day) improved stool frequency (3.5 vs. 2.8 CSBM per week, P = 0.006) and stool consistency (3.2 vs. 2.8 on Bristol stool form scale, P = 0.02) compared with psyllium (22 g/day). In non-constipated subjects, prunes softened stool consistency in one trial and increased stool weight (628 g vs. 514 g/72 h wet weight, P = 0.001) in another trial, compared with control. No trials found differences in GI symptoms between prunes and comparator. Meta-analysis was not appropriate due to heterogeneity in populations and methods. Two of the trials were limited by unclear risk of bias.

CONCLUSIONS

In constipation, prunes appear superior to psyllium for improving stool frequency and consistency, however, the evidence for other outcomes and the effects in non-constipated subjects is weak. Although prunes may be a promising intervention for the management of constipation and increasing stool weight, this needs to be confirmed by further rigorous research.

Authors+Show Affiliations

Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25109788

Citation

Lever, E, et al. "Systematic Review: the Effect of Prunes On Gastrointestinal Function." Alimentary Pharmacology & Therapeutics, vol. 40, no. 7, 2014, pp. 750-8.
Lever E, Cole J, Scott SM, et al. Systematic review: the effect of prunes on gastrointestinal function. Aliment Pharmacol Ther. 2014;40(7):750-8.
Lever, E., Cole, J., Scott, S. M., Emery, P. W., & Whelan, K. (2014). Systematic review: the effect of prunes on gastrointestinal function. Alimentary Pharmacology & Therapeutics, 40(7), 750-8. https://doi.org/10.1111/apt.12913
Lever E, et al. Systematic Review: the Effect of Prunes On Gastrointestinal Function. Aliment Pharmacol Ther. 2014;40(7):750-8. PubMed PMID: 25109788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review: the effect of prunes on gastrointestinal function. AU - Lever,E, AU - Cole,J, AU - Scott,S M, AU - Emery,P W, AU - Whelan,K, Y1 - 2014/08/11/ PY - 2014/01/18/received PY - 2014/01/31/revised PY - 2014/05/02/revised PY - 2014/07/16/revised PY - 2014/07/18/revised PY - 2014/07/21/accepted PY - 2014/8/12/entrez PY - 2014/8/12/pubmed PY - 2014/12/30/medline SP - 750 EP - 8 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 40 IS - 7 N2 - BACKGROUND: Prunes (dried plums) are high in fibre and are perceived to promote healthy gastrointestinal (GI) function. AIM: To assess the effect of prunes on GI function through a systematic review of randomised controlled trials (RCTs). METHODS: Sixteen electronic databases were searched, a hand search was performed and key opinion leaders were contacted. RCTs investigating the effect of prunes on GI function were included. Two reviewers independently screened relevant articles, extracted data and assessed risk of bias. RESULTS: Four trials met the inclusion criteria, one in constipation and three in non-constipated subjects. In constipation, 3 weeks of prune consumption (100 g/day) improved stool frequency (3.5 vs. 2.8 CSBM per week, P = 0.006) and stool consistency (3.2 vs. 2.8 on Bristol stool form scale, P = 0.02) compared with psyllium (22 g/day). In non-constipated subjects, prunes softened stool consistency in one trial and increased stool weight (628 g vs. 514 g/72 h wet weight, P = 0.001) in another trial, compared with control. No trials found differences in GI symptoms between prunes and comparator. Meta-analysis was not appropriate due to heterogeneity in populations and methods. Two of the trials were limited by unclear risk of bias. CONCLUSIONS: In constipation, prunes appear superior to psyllium for improving stool frequency and consistency, however, the evidence for other outcomes and the effects in non-constipated subjects is weak. Although prunes may be a promising intervention for the management of constipation and increasing stool weight, this needs to be confirmed by further rigorous research. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/25109788/Systematic_review:_the_effect_of_prunes_on_gastrointestinal_function_ L2 - https://doi.org/10.1111/apt.12913 DB - PRIME DP - Unbound Medicine ER -