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Bioaccumulation and toxicity of CuO nanoparticles by a freshwater invertebrate after waterborne and dietborne exposures.
Environ Sci Technol. 2014 Sep 16; 48(18):10929-37.ES

Abstract

The incidental ingestion of engineered nanoparticles (NPs) can be an important route of uptake for aquatic organisms. Yet, knowledge of dietary bioavailability and toxicity of NPs is scarce. Here we used isotopically modified copper oxide ((65)CuO) NPs to characterize the processes governing their bioaccumulation in a freshwater snail after waterborne and dietborne exposures. Lymnaea stagnalis efficiently accumulated (65)Cu after aqueous and dietary exposures to (65)CuO NPs. Cu assimilation efficiency and feeding rates averaged 83% and 0.61 g g(-1) d(-1) at low exposure concentrations (<100 nmol g(-1)), and declined by nearly 50% above this concentration. We estimated that 80-90% of the bioaccumulated (65)Cu concentration in L. stagnalis originated from the (65)CuO NPs, suggesting that dissolution had a negligible influence on Cu uptake from the NPs under our experimental conditions. The physiological loss of (65)Cu incorporated into tissues after exposures to (65)CuO NPs was rapid over the first days of depuration and not detectable thereafter. As a result, large Cu body concentrations are expected in L. stagnalis after exposure to CuO NPs. To the degree that there is a link between bioaccumulation and toxicity, dietborne exposures to CuO NPs are likely to elicit adverse effects more readily than waterborne exposures.

Authors+Show Affiliations

U.S. Geological Survey , Menlo Park, California 94025, United States.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25110983

Citation

Croteau, Marie-Noële, et al. "Bioaccumulation and Toxicity of CuO Nanoparticles By a Freshwater Invertebrate After Waterborne and Dietborne Exposures." Environmental Science & Technology, vol. 48, no. 18, 2014, pp. 10929-37.
Croteau MN, Misra SK, Luoma SN, et al. Bioaccumulation and toxicity of CuO nanoparticles by a freshwater invertebrate after waterborne and dietborne exposures. Environ Sci Technol. 2014;48(18):10929-37.
Croteau, M. N., Misra, S. K., Luoma, S. N., & Valsami-Jones, E. (2014). Bioaccumulation and toxicity of CuO nanoparticles by a freshwater invertebrate after waterborne and dietborne exposures. Environmental Science & Technology, 48(18), 10929-37. https://doi.org/10.1021/es5018703
Croteau MN, et al. Bioaccumulation and Toxicity of CuO Nanoparticles By a Freshwater Invertebrate After Waterborne and Dietborne Exposures. Environ Sci Technol. 2014 Sep 16;48(18):10929-37. PubMed PMID: 25110983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioaccumulation and toxicity of CuO nanoparticles by a freshwater invertebrate after waterborne and dietborne exposures. AU - Croteau,Marie-Noële, AU - Misra,Superb K, AU - Luoma,Samuel N, AU - Valsami-Jones,Eugenia, Y1 - 2014/08/22/ PY - 2014/8/12/entrez PY - 2014/8/12/pubmed PY - 2015/11/11/medline SP - 10929 EP - 37 JF - Environmental science & technology JO - Environ Sci Technol VL - 48 IS - 18 N2 - The incidental ingestion of engineered nanoparticles (NPs) can be an important route of uptake for aquatic organisms. Yet, knowledge of dietary bioavailability and toxicity of NPs is scarce. Here we used isotopically modified copper oxide ((65)CuO) NPs to characterize the processes governing their bioaccumulation in a freshwater snail after waterborne and dietborne exposures. Lymnaea stagnalis efficiently accumulated (65)Cu after aqueous and dietary exposures to (65)CuO NPs. Cu assimilation efficiency and feeding rates averaged 83% and 0.61 g g(-1) d(-1) at low exposure concentrations (<100 nmol g(-1)), and declined by nearly 50% above this concentration. We estimated that 80-90% of the bioaccumulated (65)Cu concentration in L. stagnalis originated from the (65)CuO NPs, suggesting that dissolution had a negligible influence on Cu uptake from the NPs under our experimental conditions. The physiological loss of (65)Cu incorporated into tissues after exposures to (65)CuO NPs was rapid over the first days of depuration and not detectable thereafter. As a result, large Cu body concentrations are expected in L. stagnalis after exposure to CuO NPs. To the degree that there is a link between bioaccumulation and toxicity, dietborne exposures to CuO NPs are likely to elicit adverse effects more readily than waterborne exposures. SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/25110983/Bioaccumulation_and_toxicity_of_CuO_nanoparticles_by_a_freshwater_invertebrate_after_waterborne_and_dietborne_exposures_ DB - PRIME DP - Unbound Medicine ER -