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Low levels of 25-hydroxy vitamin D and active 1,25-dihydroxyvitamin D independently associated with type 2 diabetes mellitus in older Australian men: the Concord Health and Ageing in Men Project.
J Am Geriatr Soc. 2014 Sep; 62(9):1741-7.JA

Abstract

OBJECTIVES

To examine the associations between serum 25-hydroxyvitamin D (25OHD) levels and the active vitamin D metabolite, 1,25-hydroxyvitamin D (1,25OHD), with type 2 diabetes mellitus (DM) in community-living men aged 70 and older.

DESIGN

Cross-sectional.

SETTING

A population-based, cross-sectional analysis of the baseline phase of the Concord Health and Ageing in Men Project (CHAMP), a large epidemiological study conducted in Sydney between January 2005 and May 2007.

PARTICIPANTS

Community dwelling men aged 70 and older taking part in CHAMP (N = 1,659).

MEASUREMENTS

Serum 25OHD and 1,25OHD levels, presence of DM, age, country of birth, season of blood collection, sun exposure, body mass index, vitamin D supplement use, statin use, income, measures of health, depression, activity of daily living disabilities, parathyroid hormone, estimated glomerular filtration rate, phosphate, and calcium.

RESULTS

The prevalence of DM was 20.0%. There was a significant association between low 25OHD and 1,25OHD levels and DM that remained after adjustment for a wide range of confounders and covariates of clinical significance such as comorbidity, renal function, calciotropic hormones, and medications.

CONCLUSION

25OHD and 1,25OHD levels were associated with DM. The independent association between serum 25OHD and 1,25OHD concentrations and DM raises the question of whether each of the two vitamin D metabolites may influence DM through different biological mechanisms and pathways.

Authors+Show Affiliations

Centre for Education and Research on Ageing, University of Sydney, Sydney, New South Wales, Australia; School of Public Health, University of Sydney, Sydney, New South Wales, Australia; ARC Centre of Excellence in Population Ageing Research, University of Sydney, Sydney, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25112415

Citation

Hirani, Vasant, et al. "Low Levels of 25-hydroxy Vitamin D and Active 1,25-dihydroxyvitamin D Independently Associated With Type 2 Diabetes Mellitus in Older Australian Men: the Concord Health and Ageing in Men Project." Journal of the American Geriatrics Society, vol. 62, no. 9, 2014, pp. 1741-7.
Hirani V, Cumming RG, Le Couteur DG, et al. Low levels of 25-hydroxy vitamin D and active 1,25-dihydroxyvitamin D independently associated with type 2 diabetes mellitus in older Australian men: the Concord Health and Ageing in Men Project. J Am Geriatr Soc. 2014;62(9):1741-7.
Hirani, V., Cumming, R. G., Le Couteur, D. G., Naganathan, V., Blyth, F., Handelsman, D. J., Waite, L. M., & Seibel, M. J. (2014). Low levels of 25-hydroxy vitamin D and active 1,25-dihydroxyvitamin D independently associated with type 2 diabetes mellitus in older Australian men: the Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 62(9), 1741-7. https://doi.org/10.1111/jgs.12975
Hirani V, et al. Low Levels of 25-hydroxy Vitamin D and Active 1,25-dihydroxyvitamin D Independently Associated With Type 2 Diabetes Mellitus in Older Australian Men: the Concord Health and Ageing in Men Project. J Am Geriatr Soc. 2014;62(9):1741-7. PubMed PMID: 25112415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low levels of 25-hydroxy vitamin D and active 1,25-dihydroxyvitamin D independently associated with type 2 diabetes mellitus in older Australian men: the Concord Health and Ageing in Men Project. AU - Hirani,Vasant, AU - Cumming,Robert G, AU - Le Couteur,David G, AU - Naganathan,Vasikaran, AU - Blyth,Fiona, AU - Handelsman,David J, AU - Waite,Louise M, AU - Seibel,Markus J, Y1 - 2014/08/12/ PY - 2014/8/13/entrez PY - 2014/8/13/pubmed PY - 2014/12/15/medline KW - calcitriol KW - diabetes mellitus KW - older men KW - population study KW - vitamin D SP - 1741 EP - 7 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 62 IS - 9 N2 - OBJECTIVES: To examine the associations between serum 25-hydroxyvitamin D (25OHD) levels and the active vitamin D metabolite, 1,25-hydroxyvitamin D (1,25OHD), with type 2 diabetes mellitus (DM) in community-living men aged 70 and older. DESIGN: Cross-sectional. SETTING: A population-based, cross-sectional analysis of the baseline phase of the Concord Health and Ageing in Men Project (CHAMP), a large epidemiological study conducted in Sydney between January 2005 and May 2007. PARTICIPANTS: Community dwelling men aged 70 and older taking part in CHAMP (N = 1,659). MEASUREMENTS: Serum 25OHD and 1,25OHD levels, presence of DM, age, country of birth, season of blood collection, sun exposure, body mass index, vitamin D supplement use, statin use, income, measures of health, depression, activity of daily living disabilities, parathyroid hormone, estimated glomerular filtration rate, phosphate, and calcium. RESULTS: The prevalence of DM was 20.0%. There was a significant association between low 25OHD and 1,25OHD levels and DM that remained after adjustment for a wide range of confounders and covariates of clinical significance such as comorbidity, renal function, calciotropic hormones, and medications. CONCLUSION: 25OHD and 1,25OHD levels were associated with DM. The independent association between serum 25OHD and 1,25OHD concentrations and DM raises the question of whether each of the two vitamin D metabolites may influence DM through different biological mechanisms and pathways. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/25112415/Low_levels_of_25_hydroxy_vitamin_D_and_active_125_dihydroxyvitamin_D_independently_associated_with_type_2_diabetes_mellitus_in_older_Australian_men:_the_Concord_Health_and_Ageing_in_Men_Project_ L2 - https://doi.org/10.1111/jgs.12975 DB - PRIME DP - Unbound Medicine ER -