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Novel cucurbitane triterpenoids and anti-cholinesterase activities of constituents from Momordica charantia L.
Nat Prod Commun. 2014 Jun; 9(6):765-9.NP

Abstract

The C-19 epimers of 5beta,19-epoxycucurbita-6,23(E),25(26)-triene-3f,19-diol (1) and 5/,19-epoxy-25-methoxycucurbita-6,23-diene-3beta,19-diol (2) along with (19R,23E)-5beta,19-epoxy-19-methoxycucurbita-6,23,25-trien-3beta-ol (3), (23E)-5beta,19-epoxycucurbita-6,23-diene-3beta,25-diol (4), ligballinol (5), charantin (6) and momordicoside K(7) were isolated from the green fruits of Momordica charantia. The (S)-epimers of 1 and 2 are the first reports in nature. The acetyl- and butyryl-cholinesterase inhibitory activities of the isolated compounds were evaluated, and 5 showed the highest activity of these compounds against butyrylcholinesterase (IC50 = 32.20 microM) with a reversible and non-competitive inhibition mode.

Authors

Kuanhuta W
No affiliation info available
Aree T
No affiliation info available
Pornpakakul S
No affiliation info available
Sawasdee P
No affiliation info available

MeSH

Cholinesterase InhibitorsFruitGlycosidesModels, MolecularMolecular StructureMomordica charantiaTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25115074

Citation

Kuanhuta, Wichut, et al. "Novel Cucurbitane Triterpenoids and Anti-cholinesterase Activities of Constituents From Momordica Charantia L." Natural Product Communications, vol. 9, no. 6, 2014, pp. 765-9.
Kuanhuta W, Aree T, Pornpakakul S, et al. Novel cucurbitane triterpenoids and anti-cholinesterase activities of constituents from Momordica charantia L. Nat Prod Commun. 2014;9(6):765-9.
Kuanhuta, W., Aree, T., Pornpakakul, S., & Sawasdee, P. (2014). Novel cucurbitane triterpenoids and anti-cholinesterase activities of constituents from Momordica charantia L. Natural Product Communications, 9(6), 765-9.
Kuanhuta W, et al. Novel Cucurbitane Triterpenoids and Anti-cholinesterase Activities of Constituents From Momordica Charantia L. Nat Prod Commun. 2014;9(6):765-9. PubMed PMID: 25115074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel cucurbitane triterpenoids and anti-cholinesterase activities of constituents from Momordica charantia L. AU - Kuanhuta,Wichut, AU - Aree,Thammarat, AU - Pornpakakul,Surachai, AU - Sawasdee,Pattara, PY - 2014/8/14/entrez PY - 2014/8/15/pubmed PY - 2014/9/16/medline SP - 765 EP - 9 JF - Natural product communications JO - Nat Prod Commun VL - 9 IS - 6 N2 - The C-19 epimers of 5beta,19-epoxycucurbita-6,23(E),25(26)-triene-3f,19-diol (1) and 5/,19-epoxy-25-methoxycucurbita-6,23-diene-3beta,19-diol (2) along with (19R,23E)-5beta,19-epoxy-19-methoxycucurbita-6,23,25-trien-3beta-ol (3), (23E)-5beta,19-epoxycucurbita-6,23-diene-3beta,25-diol (4), ligballinol (5), charantin (6) and momordicoside K(7) were isolated from the green fruits of Momordica charantia. The (S)-epimers of 1 and 2 are the first reports in nature. The acetyl- and butyryl-cholinesterase inhibitory activities of the isolated compounds were evaluated, and 5 showed the highest activity of these compounds against butyrylcholinesterase (IC50 = 32.20 microM) with a reversible and non-competitive inhibition mode. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/25115074/Novel_cucurbitane_triterpenoids_and_anti_cholinesterase_activities_of_constituents_from_Momordica_charantia_L_ DB - PRIME DP - Unbound Medicine ER -