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The use of plasma exchange in Hashimoto's encephalopathy: A case report and review of the literature.

Abstract

Hashimoto's Encephalopathy (HE) is a very rare condition characterized by psychosis, seizures, cognitive fluctuations, and myoclonus. In a few published cases, plasma exchange has been used due to the theoretical removal of antithyroid peroxidase antibodies (anti-TPO), one of the postulated causes of the condition. We report a case of HE treated by plasma exchange where no clinical or neurophysiologic improvement was observed despite documented reduction of the anti-TPO antibody to levels below the limits of laboratory detection. We discuss these findings in the context of the known literature for this disease process.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.

    ,

    Department of Neurology, Virginia Commonwealth University, Richmond, Virginia.

    Medical Sciences Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin. Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.

    Source

    Journal of clinical apheresis 30:3 2015 Jun pg 188-92

    MeSH

    Autoantibodies
    Blood Component Removal
    Cognition Disorders
    Encephalitis
    Female
    Hashimoto Disease
    Humans
    Immunoglobulins, Intravenous
    Iodide Peroxidase
    Middle Aged
    Paranoid Disorders
    Plasma Exchange
    Plasmapheresis
    Status Epilepticus
    Steroids

    Pub Type(s)

    Case Reports
    Journal Article
    Review

    Language

    eng

    PubMed ID

    25116126

    Citation

    Cook, Melissa K., et al. "The Use of Plasma Exchange in Hashimoto's Encephalopathy: a Case Report and Review of the Literature." Journal of Clinical Apheresis, vol. 30, no. 3, 2015, pp. 188-92.
    Cook MK, Malkin M, Karafin MS. The use of plasma exchange in Hashimoto's encephalopathy: A case report and review of the literature. J Clin Apher. 2015;30(3):188-92.
    Cook, M. K., Malkin, M., & Karafin, M. S. (2015). The use of plasma exchange in Hashimoto's encephalopathy: A case report and review of the literature. Journal of Clinical Apheresis, 30(3), pp. 188-92. doi:10.1002/jca.21353.
    Cook MK, Malkin M, Karafin MS. The Use of Plasma Exchange in Hashimoto's Encephalopathy: a Case Report and Review of the Literature. J Clin Apher. 2015;30(3):188-92. PubMed PMID: 25116126.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The use of plasma exchange in Hashimoto's encephalopathy: A case report and review of the literature. AU - Cook,Melissa K, AU - Malkin,Mark, AU - Karafin,Matthew S, Y1 - 2014/08/12/ PY - 2014/02/10/received PY - 2014/07/28/revised PY - 2014/07/30/accepted PY - 2014/8/14/entrez PY - 2014/8/15/pubmed PY - 2016/4/5/medline KW - Hashimoto's encephalopathy KW - pheresis indications KW - plasma exchange SP - 188 EP - 92 JF - Journal of clinical apheresis JO - J Clin Apher VL - 30 IS - 3 N2 - Hashimoto's Encephalopathy (HE) is a very rare condition characterized by psychosis, seizures, cognitive fluctuations, and myoclonus. In a few published cases, plasma exchange has been used due to the theoretical removal of antithyroid peroxidase antibodies (anti-TPO), one of the postulated causes of the condition. We report a case of HE treated by plasma exchange where no clinical or neurophysiologic improvement was observed despite documented reduction of the anti-TPO antibody to levels below the limits of laboratory detection. We discuss these findings in the context of the known literature for this disease process. SN - 1098-1101 UR - https://www.unboundmedicine.com/medline/citation/25116126/The_use_of_plasma_exchange_in_Hashimoto's_encephalopathy:_A_case_report_and_review_of_the_literature_ L2 - https://doi.org/10.1002/jca.21353 DB - PRIME DP - Unbound Medicine ER -