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The use of plasma exchange in Hashimoto's encephalopathy: A case report and review of the literature.
Hashimoto's Encephalopathy (HE) is a very rare condition characterized by psychosis, seizures, cognitive fluctuations, and myoclonus. In a few published cases, plasma exchange has been used due to the theoretical removal of antithyroid peroxidase antibodies (anti-TPO), one of the postulated causes of the condition. We report a case of HE treated by plasma exchange where no clinical or neurophysiologic improvement was observed despite documented reduction of the anti-TPO antibody to levels below the limits of laboratory detection. We discuss these findings in the context of the known literature for this disease process.
Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.,
Department of Neurology, Virginia Commonwealth University, Richmond, Virginia.
Medical Sciences Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin. Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Blood Component Removal
Pub Type(s)Case Reports