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Oxidative stress and biochemical responses in the tissues of African catfish Clarias gariepinus juvenile following exposure to primextra herbicide.
Drug Chem Toxicol. 2015; 38(3):278-85.DC

Abstract

Primextra is a commercial herbicide formulation generally used in agriculture for weed control. The present study was designed to investigate the oxidative stress biomarkers and biochemical responses in the tissues of Clarias gariepinus juvenile exposed to primextra. Fish were exposed to 0.24 and 0.47 mgL(-1) corresponding to 1/20 and 1/10th of 96 h LC50 of the herbicide. The liver and muscle tissues were sampled on day 1, 5, 10 and 15 and results showed concentration and time dependent significant increase (p < 0.05) in the values of lipid peroxidation, glutathione peroxidase, catalase and alkaline phosphatase in both tissues. A marked significant increase (p < 0.05) was observed in the values of aspartate aminotransferase, alanine aminotransferase and glucose in the liver while a mixed trend in their values were observed in the muscle. The values of superoxide dismutase and protein in both tissues were comparable to the control except on day 15 in the liver where the values significantly declined. The condition factor was not directly affected but values of hepatosomatic index were significantly reduced. The present findings revealed that primextra induced toxic stress even at sublethal concentrations resulting in alterations of the studied parameters which were more evident in the fish liver than in the muscle tissue.

Authors+Show Affiliations

Molecular Biology and Biotechnology Division, Department of Zoology and Environmental Biology, University of Nigeria, Nsukka , Nigeria .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25116447

Citation

Nwani, Christopher Didigwu, et al. "Oxidative Stress and Biochemical Responses in the Tissues of African Catfish Clarias Gariepinus Juvenile Following Exposure to Primextra Herbicide." Drug and Chemical Toxicology, vol. 38, no. 3, 2015, pp. 278-85.
Nwani CD, Ifo CT, Nwamba HO, et al. Oxidative stress and biochemical responses in the tissues of African catfish Clarias gariepinus juvenile following exposure to primextra herbicide. Drug Chem Toxicol. 2015;38(3):278-85.
Nwani, C. D., Ifo, C. T., Nwamba, H. O., Ejere, V. C., Onyishi, G. C., Oluah, S. N., Ikwuagwu, O. E., & Odo, G. E. (2015). Oxidative stress and biochemical responses in the tissues of African catfish Clarias gariepinus juvenile following exposure to primextra herbicide. Drug and Chemical Toxicology, 38(3), 278-85. https://doi.org/10.3109/01480545.2014.947503
Nwani CD, et al. Oxidative Stress and Biochemical Responses in the Tissues of African Catfish Clarias Gariepinus Juvenile Following Exposure to Primextra Herbicide. Drug Chem Toxicol. 2015;38(3):278-85. PubMed PMID: 25116447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and biochemical responses in the tissues of African catfish Clarias gariepinus juvenile following exposure to primextra herbicide. AU - Nwani,Christopher Didigwu, AU - Ifo,Charles Tobechukwu, AU - Nwamba,Helen Ogochukwu, AU - Ejere,Vincent Chikwendu, AU - Onyishi,Grace Chinenye, AU - Oluah,Stanley Ndubuisi, AU - Ikwuagwu,Ogbonnaya Egbe, AU - Odo,Gregory Ejike, Y1 - 2014/08/13/ PY - 2014/8/14/entrez PY - 2014/8/15/pubmed PY - 2016/5/25/medline KW - Biochemical alterations KW - Clarias gariepinus KW - oxidative stress biomarkers KW - primextra SP - 278 EP - 85 JF - Drug and chemical toxicology JO - Drug Chem Toxicol VL - 38 IS - 3 N2 - Primextra is a commercial herbicide formulation generally used in agriculture for weed control. The present study was designed to investigate the oxidative stress biomarkers and biochemical responses in the tissues of Clarias gariepinus juvenile exposed to primextra. Fish were exposed to 0.24 and 0.47 mgL(-1) corresponding to 1/20 and 1/10th of 96 h LC50 of the herbicide. The liver and muscle tissues were sampled on day 1, 5, 10 and 15 and results showed concentration and time dependent significant increase (p < 0.05) in the values of lipid peroxidation, glutathione peroxidase, catalase and alkaline phosphatase in both tissues. A marked significant increase (p < 0.05) was observed in the values of aspartate aminotransferase, alanine aminotransferase and glucose in the liver while a mixed trend in their values were observed in the muscle. The values of superoxide dismutase and protein in both tissues were comparable to the control except on day 15 in the liver where the values significantly declined. The condition factor was not directly affected but values of hepatosomatic index were significantly reduced. The present findings revealed that primextra induced toxic stress even at sublethal concentrations resulting in alterations of the studied parameters which were more evident in the fish liver than in the muscle tissue. SN - 1525-6014 UR - https://www.unboundmedicine.com/medline/citation/25116447/Oxidative_stress_and_biochemical_responses_in_the_tissues_of_African_catfish_Clarias_gariepinus_juvenile_following_exposure_to_primextra_herbicide_ L2 - https://www.tandfonline.com/doi/full/10.3109/01480545.2014.947503 DB - PRIME DP - Unbound Medicine ER -