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A three-year review of antimicrobial resistance of Salmonella enterica serovars Typhi and Paratyphi A in Pakistan.
J Infect Dev Ctries. 2014 Aug 13; 8(8):981-6.JI

Abstract

INTRODUCTION

Enteric fever is among the most common bacteraemic illnesses in South Asia. Multidrug resistance as well as fluoroquinolone resistance has severely limited therapeutic options in high disease burden countries such as Pakistan. This review was conducted to determine the frequency of drug-resistant Salmonella enterica serovar Typhi (S.Typhi) and Salmonella enterica serovar Paratyphi A (S. Paratyphi A) between 2009 and 2011.

METHODOLOGY

This study was a review of laboratory data. The antibiotic susceptibility of typhoidal Salmonellae isolated from blood cultures submitted to the Aga Khan University Hospital's laboratory from all over Pakistan between January 2009 and December 2011 were reviewed.

RESULTS

The sensitivity data of 4,323 positive isolates of S. Typhi and S. Paratyphi A isolated during the three-year period were reviewed. The majority of isolates were S. Typhi (59.6%).Over three years, the incidence of multidrug-resistant (MDR) S.Typhi remained high, ranging from 64.8%-66.0%, while MDR S. Paratyphi A decreased from 4.2% to 0.6%. Fluoroquinolone resistance increased for S. Typhi from 84.7% to 91.7%. Cefixime- and ceftriaxone-resistant S. Typhi were isolated in two children.

CONCLUSIONS

Our results show high rates of multidrug and fluoroquinolone resistance among S. Typhi and S. Paratyphi. The occurrence of two cases of ceftriaxone resistance is alarming.

Authors+Show Affiliations

Aga Khan University Hospital, Karachi, Pakistan. farah.qamar@aku.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25116662

Citation

Qamar, Farah Naz, et al. "A Three-year Review of Antimicrobial Resistance of Salmonella Enterica Serovars Typhi and Paratyphi a in Pakistan." Journal of Infection in Developing Countries, vol. 8, no. 8, 2014, pp. 981-6.
Qamar FN, Azmatullah A, Kazi AM, et al. A three-year review of antimicrobial resistance of Salmonella enterica serovars Typhi and Paratyphi A in Pakistan. J Infect Dev Ctries. 2014;8(8):981-6.
Qamar, F. N., Azmatullah, A., Kazi, A. M., Khan, E., & Zaidi, A. K. (2014). A three-year review of antimicrobial resistance of Salmonella enterica serovars Typhi and Paratyphi A in Pakistan. Journal of Infection in Developing Countries, 8(8), 981-6. https://doi.org/10.3855/jidc.3817
Qamar FN, et al. A Three-year Review of Antimicrobial Resistance of Salmonella Enterica Serovars Typhi and Paratyphi a in Pakistan. J Infect Dev Ctries. 2014 Aug 13;8(8):981-6. PubMed PMID: 25116662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A three-year review of antimicrobial resistance of Salmonella enterica serovars Typhi and Paratyphi A in Pakistan. AU - Qamar,Farah Naz, AU - Azmatullah,Asma, AU - Kazi,Abdul Momin, AU - Khan,Erum, AU - Zaidi,Anita Kaniz Mehdi, Y1 - 2014/08/13/ PY - 2013/05/22/received PY - 2014/01/22/accepted PY - 2013/12/04/revised PY - 2014/8/14/entrez PY - 2014/8/15/pubmed PY - 2015/4/23/medline SP - 981 EP - 6 JF - Journal of infection in developing countries JO - J Infect Dev Ctries VL - 8 IS - 8 N2 - INTRODUCTION: Enteric fever is among the most common bacteraemic illnesses in South Asia. Multidrug resistance as well as fluoroquinolone resistance has severely limited therapeutic options in high disease burden countries such as Pakistan. This review was conducted to determine the frequency of drug-resistant Salmonella enterica serovar Typhi (S.Typhi) and Salmonella enterica serovar Paratyphi A (S. Paratyphi A) between 2009 and 2011. METHODOLOGY: This study was a review of laboratory data. The antibiotic susceptibility of typhoidal Salmonellae isolated from blood cultures submitted to the Aga Khan University Hospital's laboratory from all over Pakistan between January 2009 and December 2011 were reviewed. RESULTS: The sensitivity data of 4,323 positive isolates of S. Typhi and S. Paratyphi A isolated during the three-year period were reviewed. The majority of isolates were S. Typhi (59.6%).Over three years, the incidence of multidrug-resistant (MDR) S.Typhi remained high, ranging from 64.8%-66.0%, while MDR S. Paratyphi A decreased from 4.2% to 0.6%. Fluoroquinolone resistance increased for S. Typhi from 84.7% to 91.7%. Cefixime- and ceftriaxone-resistant S. Typhi were isolated in two children. CONCLUSIONS: Our results show high rates of multidrug and fluoroquinolone resistance among S. Typhi and S. Paratyphi. The occurrence of two cases of ceftriaxone resistance is alarming. SN - 1972-2680 UR - https://www.unboundmedicine.com/medline/citation/25116662/A_three_year_review_of_antimicrobial_resistance_of_Salmonella_enterica_serovars_Typhi_and_Paratyphi_A_in_Pakistan_ L2 - http://www.jidc.org/index.php/journal/article/view/25116662 DB - PRIME DP - Unbound Medicine ER -