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Salt restriction in chronic kidney disease: a simple need or a must?
Kidney Blood Press Res. 2014; 39(2-3):124-8.KB

Abstract

Dietary salt restriction is one of the most important non pharmacological intervention in the management of hypertension and cardiovascular complications. In Chronic Kidney Disease (CKD) patients, observational and recent interventional studies investigating the relationship between sodium intake and renal outcomes suggest that low salt diet is warranted in this high risk category of patients. Moreover reducing and maintaining a low salt intake in these patients plays a fundamental role for maximizing the beneficial effect of ACE inhibitors on CKD progression. On the other hand, in hypertensive patients there is experimental evidence indicating that a very low sodium diet (<50 mEq/day) generates a pro-inflammatory phenotype characterized by an increase in Procalcitonin and TNF-alpha and a reduction in an anti-inflammatory cytokine like Adiponectin. In this brief review the main mechanisms whereby salt intake may determine kidney damage and studies showing that salt restriction may have a beneficial effect in CKD patients will be discussed.

Authors+Show Affiliations

Nephrology, Dialysis and Transplantation Unit & CNR-IFC/IBIM Reggio Calabria, Italy.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25117718

Citation

Mallamaci, Francesca, and Giovanni Tripepi. "Salt Restriction in Chronic Kidney Disease: a Simple Need or a Must?" Kidney & Blood Pressure Research, vol. 39, no. 2-3, 2014, pp. 124-8.
Mallamaci F, Tripepi G. Salt restriction in chronic kidney disease: a simple need or a must? Kidney Blood Press Res. 2014;39(2-3):124-8.
Mallamaci, F., & Tripepi, G. (2014). Salt restriction in chronic kidney disease: a simple need or a must? Kidney & Blood Pressure Research, 39(2-3), 124-8. https://doi.org/10.1159/000355786
Mallamaci F, Tripepi G. Salt Restriction in Chronic Kidney Disease: a Simple Need or a Must. Kidney Blood Press Res. 2014;39(2-3):124-8. PubMed PMID: 25117718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salt restriction in chronic kidney disease: a simple need or a must? AU - Mallamaci,Francesca, AU - Tripepi,Giovanni, Y1 - 2014/07/29/ PY - 2014/04/11/accepted PY - 2014/8/14/entrez PY - 2014/8/15/pubmed PY - 2015/5/29/medline SP - 124 EP - 8 JF - Kidney & blood pressure research JO - Kidney Blood Press Res VL - 39 IS - 2-3 N2 - Dietary salt restriction is one of the most important non pharmacological intervention in the management of hypertension and cardiovascular complications. In Chronic Kidney Disease (CKD) patients, observational and recent interventional studies investigating the relationship between sodium intake and renal outcomes suggest that low salt diet is warranted in this high risk category of patients. Moreover reducing and maintaining a low salt intake in these patients plays a fundamental role for maximizing the beneficial effect of ACE inhibitors on CKD progression. On the other hand, in hypertensive patients there is experimental evidence indicating that a very low sodium diet (<50 mEq/day) generates a pro-inflammatory phenotype characterized by an increase in Procalcitonin and TNF-alpha and a reduction in an anti-inflammatory cytokine like Adiponectin. In this brief review the main mechanisms whereby salt intake may determine kidney damage and studies showing that salt restriction may have a beneficial effect in CKD patients will be discussed. SN - 1423-0143 UR - https://www.unboundmedicine.com/medline/citation/25117718/Salt_restriction_in_chronic_kidney_disease:_a_simple_need_or_a_must L2 - https://www.karger.com?DOI=10.1159/000355786 DB - PRIME DP - Unbound Medicine ER -