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Risperidone-associated urinary incontinence in patients with autistic disorder with mental retardation.
J Clin Psychopharmacol. 2014 Oct; 34(5):624-6.JC

Abstract

We report several cases in which patients with autistic disorder with mental retardation who received risperidone experienced urinary incontinence. We retrospectively investigated the medical records of patients housed in facilities for patients with autistic disorder with mental retardation. Those who had undergone a medical examination at a hospital in Tokyo from April 1999 to March 2009 were included in the study.Retrospective data were gathered including age, sex, IQ, birth weight, dosage of risperidone, urinary density, as well as existence of urinary and fecal incontinence. We divided the participants into those who did and did not experience urinary incontinence after taking risperidone and compared the 2 groups. Risperidone had been prescribed to 35 patients. In spite of the fact that no patient had a history of urinary incontinence, 14 patients experienced urinary incontinence after receiving risperidone. Moreover, 4 of these 14 patients also had fecal incontinence. Among the variables we examined, the only significant difference between groups was in sex, with significantly more women experiencing incontinence compared with men. When the dose of risperidone was reduced or the patients switched to other drugs, urinary incontinence of the patients improved.Hence, risperidone may have a casual relationship with urinary incontinence. Further research is needed to understand the pathophysiology of possible effect.

Authors+Show Affiliations

From the *Research Center for Child Mental Development, Fukui University, Fukui; †Department of Neuropsychiatry, Keio University School of Medicine; ‡Department of Neuropsychiatry, Kyorin University School of Medicine; §Department of Psychiatry, Oizumi Hospital, Tokyo; and ∥Department of Child and Adolescent Medicine, Osaka Psychiatric Medical Center, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25118082

Citation

Kumazaki, Hirokazu, et al. "Risperidone-associated Urinary Incontinence in Patients With Autistic Disorder With Mental Retardation." Journal of Clinical Psychopharmacology, vol. 34, no. 5, 2014, pp. 624-6.
Kumazaki H, Watanabe K, Imasaka Y, et al. Risperidone-associated urinary incontinence in patients with autistic disorder with mental retardation. J Clin Psychopharmacol. 2014;34(5):624-6.
Kumazaki, H., Watanabe, K., Imasaka, Y., Iwata, K., Tomoda, A., & Mimura, M. (2014). Risperidone-associated urinary incontinence in patients with autistic disorder with mental retardation. Journal of Clinical Psychopharmacology, 34(5), 624-6. https://doi.org/10.1097/JCP.0000000000000197
Kumazaki H, et al. Risperidone-associated Urinary Incontinence in Patients With Autistic Disorder With Mental Retardation. J Clin Psychopharmacol. 2014;34(5):624-6. PubMed PMID: 25118082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risperidone-associated urinary incontinence in patients with autistic disorder with mental retardation. AU - Kumazaki,Hirokazu, AU - Watanabe,Koichiro, AU - Imasaka,Yasushi, AU - Iwata,Kazuhiko, AU - Tomoda,Akemi, AU - Mimura,Masaru, PY - 2014/8/14/entrez PY - 2014/8/15/pubmed PY - 2016/2/26/medline SP - 624 EP - 6 JF - Journal of clinical psychopharmacology JO - J Clin Psychopharmacol VL - 34 IS - 5 N2 - We report several cases in which patients with autistic disorder with mental retardation who received risperidone experienced urinary incontinence. We retrospectively investigated the medical records of patients housed in facilities for patients with autistic disorder with mental retardation. Those who had undergone a medical examination at a hospital in Tokyo from April 1999 to March 2009 were included in the study.Retrospective data were gathered including age, sex, IQ, birth weight, dosage of risperidone, urinary density, as well as existence of urinary and fecal incontinence. We divided the participants into those who did and did not experience urinary incontinence after taking risperidone and compared the 2 groups. Risperidone had been prescribed to 35 patients. In spite of the fact that no patient had a history of urinary incontinence, 14 patients experienced urinary incontinence after receiving risperidone. Moreover, 4 of these 14 patients also had fecal incontinence. Among the variables we examined, the only significant difference between groups was in sex, with significantly more women experiencing incontinence compared with men. When the dose of risperidone was reduced or the patients switched to other drugs, urinary incontinence of the patients improved.Hence, risperidone may have a casual relationship with urinary incontinence. Further research is needed to understand the pathophysiology of possible effect. SN - 1533-712X UR - https://www.unboundmedicine.com/medline/citation/25118082/Risperidone_associated_urinary_incontinence_in_patients_with_autistic_disorder_with_mental_retardation_ L2 - http://dx.doi.org/10.1097/JCP.0000000000000197 DB - PRIME DP - Unbound Medicine ER -