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Low doses of eicosapentaenoic acid and docosahexaenoic acid from fish oil dose-dependently decrease serum triglyceride concentrations in the presence of plant sterols in hypercholesterolemic men and women.
J Nutr. 2014 Oct; 144(10):1564-70.JN

Abstract

Plant sterols (PSs) lower LDL cholesterol (LDL-C) concentrations, whereas the n-3 (ω-3) fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) lower triglyceride (TG) concentrations. Incorporating both PSs and EPA+DHA from fish oil (FO) in a single food format was expected to beneficially affect 2 blood lipid risk factors. The aim of this study was to investigate the dose-response relation between low doses (<2 g/d) of EPA+DHA from FO, incorporated in a low-fat PS-enriched spread, and TG concentrations. In addition, effects on LDL-C were investigated. The study was designed as a randomized, double-blind, placebo-controlled parallel study. After a 4-wk run-in period, subjects were randomly assigned to consume either a control (C) spread (no PSs, no FO) or 1 of 4 intervention spreads containing a fixed amount of PSs (2.5 g/d) and varying amounts of FO (0.0, 0.9, 1.3, and 1.8 g/d of EPA+DHA) for 4 wk. Before and after the intervention, fasting blood samples were drawn for measuring serum lipids and EPA and DHA in erythrocyte membranes. In total, 85 hypercholesterolemic men and 247 women with a mean age of 57.9 y (range: 25-74 y) were included. Eighteen subjects dropped out during the study. At baseline, mean TG and LDL-C concentrations were 1.09 and 4.00 mmol/L, respectively. After the intervention, a significant dose-response relation for the TG-lowering effect of EPA+DHA [βln (TG) = -0.07 mmol/L per gram of EPA+DHA; P < 0.01] was found. Compared with the C group, TG concentrations were 9.3-16.2% lower in the different FO groups (P < 0.05 for all groups). LDL-C concentrations were 11.5-14.7% lower in the different PS groups than in the C group (P < 0.01 for all groups). EPA and DHA in erythrocyte membranes were dose-dependently higher after FO intake than after the C spread, indicating good compliance. Consumption of a low-fat spread enriched with PSs and different low doses of n-3 fatty acids from FO decreased TG concentrations in a dose-dependent manner and decreased LDL-C concentrations. This trial was registered at clinicaltrials.gov as NCT01313988.

Authors+Show Affiliations

Unilever Research and Development Vlaardingen, Vlaardingen, The Netherlands rouyanne.ras@unilever.com.Unilever Research and Development Vlaardingen, Vlaardingen, The Netherlands.Unilever Research and Development Vlaardingen, Vlaardingen, The Netherlands.Quadt Consultancy B.V., Oostvoorne, The Netherlands; and.Food Files (formerly known as Good Food Practice), Uppsala, Sweden.Unilever Research and Development Vlaardingen, Vlaardingen, The Netherlands.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25122648

Citation

Ras, Rouyanne T., et al. "Low Doses of Eicosapentaenoic Acid and Docosahexaenoic Acid From Fish Oil Dose-dependently Decrease Serum Triglyceride Concentrations in the Presence of Plant Sterols in Hypercholesterolemic Men and Women." The Journal of Nutrition, vol. 144, no. 10, 2014, pp. 1564-70.
Ras RT, Demonty I, Zebregs YE, et al. Low doses of eicosapentaenoic acid and docosahexaenoic acid from fish oil dose-dependently decrease serum triglyceride concentrations in the presence of plant sterols in hypercholesterolemic men and women. J Nutr. 2014;144(10):1564-70.
Ras, R. T., Demonty, I., Zebregs, Y. E., Quadt, J. F., Olsson, J., & Trautwein, E. A. (2014). Low doses of eicosapentaenoic acid and docosahexaenoic acid from fish oil dose-dependently decrease serum triglyceride concentrations in the presence of plant sterols in hypercholesterolemic men and women. The Journal of Nutrition, 144(10), 1564-70. https://doi.org/10.3945/jn.114.192229
Ras RT, et al. Low Doses of Eicosapentaenoic Acid and Docosahexaenoic Acid From Fish Oil Dose-dependently Decrease Serum Triglyceride Concentrations in the Presence of Plant Sterols in Hypercholesterolemic Men and Women. J Nutr. 2014;144(10):1564-70. PubMed PMID: 25122648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low doses of eicosapentaenoic acid and docosahexaenoic acid from fish oil dose-dependently decrease serum triglyceride concentrations in the presence of plant sterols in hypercholesterolemic men and women. AU - Ras,Rouyanne T, AU - Demonty,Isabelle, AU - Zebregs,Yvonne E M P, AU - Quadt,Johan F A, AU - Olsson,Johan, AU - Trautwein,Elke A, Y1 - 2014/08/13/ PY - 2014/8/15/entrez PY - 2014/8/15/pubmed PY - 2015/1/21/medline SP - 1564 EP - 70 JF - The Journal of nutrition JO - J Nutr VL - 144 IS - 10 N2 - Plant sterols (PSs) lower LDL cholesterol (LDL-C) concentrations, whereas the n-3 (ω-3) fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) lower triglyceride (TG) concentrations. Incorporating both PSs and EPA+DHA from fish oil (FO) in a single food format was expected to beneficially affect 2 blood lipid risk factors. The aim of this study was to investigate the dose-response relation between low doses (<2 g/d) of EPA+DHA from FO, incorporated in a low-fat PS-enriched spread, and TG concentrations. In addition, effects on LDL-C were investigated. The study was designed as a randomized, double-blind, placebo-controlled parallel study. After a 4-wk run-in period, subjects were randomly assigned to consume either a control (C) spread (no PSs, no FO) or 1 of 4 intervention spreads containing a fixed amount of PSs (2.5 g/d) and varying amounts of FO (0.0, 0.9, 1.3, and 1.8 g/d of EPA+DHA) for 4 wk. Before and after the intervention, fasting blood samples were drawn for measuring serum lipids and EPA and DHA in erythrocyte membranes. In total, 85 hypercholesterolemic men and 247 women with a mean age of 57.9 y (range: 25-74 y) were included. Eighteen subjects dropped out during the study. At baseline, mean TG and LDL-C concentrations were 1.09 and 4.00 mmol/L, respectively. After the intervention, a significant dose-response relation for the TG-lowering effect of EPA+DHA [βln (TG) = -0.07 mmol/L per gram of EPA+DHA; P < 0.01] was found. Compared with the C group, TG concentrations were 9.3-16.2% lower in the different FO groups (P < 0.05 for all groups). LDL-C concentrations were 11.5-14.7% lower in the different PS groups than in the C group (P < 0.01 for all groups). EPA and DHA in erythrocyte membranes were dose-dependently higher after FO intake than after the C spread, indicating good compliance. Consumption of a low-fat spread enriched with PSs and different low doses of n-3 fatty acids from FO decreased TG concentrations in a dose-dependent manner and decreased LDL-C concentrations. This trial was registered at clinicaltrials.gov as NCT01313988. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/25122648/Low_doses_of_eicosapentaenoic_acid_and_docosahexaenoic_acid_from_fish_oil_dose_dependently_decrease_serum_triglyceride_concentrations_in_the_presence_of_plant_sterols_in_hypercholesterolemic_men_and_women_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.114.192229 DB - PRIME DP - Unbound Medicine ER -