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Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease.
Stroke. 1989 Dec; 20(12):1662-6.S

Abstract

We determined the immediate effects of pentoxifylline on cerebral blood flow in 10 patients with cerebrovascular disease; four received 400 mg and six received 800 mg pentoxifylline orally. Regional cerebral blood flow was measured before (baseline) and 2, 4, and 6 hours after pentoxifylline administration using the xenon-133 clearance technique with 16 detectors (eight per hemisphere). Global cerebral blood flow as a percentage of the baseline value increased significantly after 800 mg but not 400 mg pentoxifylline (p = 0.017 and p = 0.29, respectively). Regional cerebral blood flow as a percentage of the baseline value at the detector with the lowest baseline value increased significantly 2 hours after both 400 mg and 800 mg pentoxifylline (p = 0.038 and p = 0.010, respectively). Cerebrovascular reactivity to carbon dioxide was preserved despite the increases in cerebral blood flow. Pentoxifylline increases cerebral blood flow and is not associated with "intracerebral steal" in patients with cerebrovascular disease.

Authors+Show Affiliations

Department of Anesthesia (Critical Care), Wake Forest University Medical Center, Winston-Salem, North Carolina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2512690

Citation

Bowton, D L., et al. "Pentoxifylline Increases Cerebral Blood Flow in Patients With Cerebrovascular Disease." Stroke, vol. 20, no. 12, 1989, pp. 1662-6.
Bowton DL, Stump DA, Prough DS, et al. Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease. Stroke. 1989;20(12):1662-6.
Bowton, D. L., Stump, D. A., Prough, D. S., Toole, J. F., Lefkowitz, D. S., & Coker, L. (1989). Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease. Stroke, 20(12), 1662-6.
Bowton DL, et al. Pentoxifylline Increases Cerebral Blood Flow in Patients With Cerebrovascular Disease. Stroke. 1989;20(12):1662-6. PubMed PMID: 2512690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease. AU - Bowton,D L, AU - Stump,D A, AU - Prough,D S, AU - Toole,J F, AU - Lefkowitz,D S, AU - Coker,L, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 1662 EP - 6 JF - Stroke JO - Stroke VL - 20 IS - 12 N2 - We determined the immediate effects of pentoxifylline on cerebral blood flow in 10 patients with cerebrovascular disease; four received 400 mg and six received 800 mg pentoxifylline orally. Regional cerebral blood flow was measured before (baseline) and 2, 4, and 6 hours after pentoxifylline administration using the xenon-133 clearance technique with 16 detectors (eight per hemisphere). Global cerebral blood flow as a percentage of the baseline value increased significantly after 800 mg but not 400 mg pentoxifylline (p = 0.017 and p = 0.29, respectively). Regional cerebral blood flow as a percentage of the baseline value at the detector with the lowest baseline value increased significantly 2 hours after both 400 mg and 800 mg pentoxifylline (p = 0.038 and p = 0.010, respectively). Cerebrovascular reactivity to carbon dioxide was preserved despite the increases in cerebral blood flow. Pentoxifylline increases cerebral blood flow and is not associated with "intracerebral steal" in patients with cerebrovascular disease. SN - 0039-2499 UR - https://www.unboundmedicine.com/medline/citation/2512690/Pentoxifylline_increases_cerebral_blood_flow_in_patients_with_cerebrovascular_disease_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.str.20.12.1662?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -