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Post-stress rumination predicts HPA axis responses to repeated acute stress.
Psychoneuroendocrinology. 2014 Nov; 49:244-52.P

Abstract

Failure of the hypothalamus-pituitary-adrenal (HPA) axis to habituate to repeated stress exposure is related with adverse health outcomes, but our knowledge of predictors of non-habituation is limited. Rumination, defined as repetitive and unwanted past-centered negative thinking, is related with exaggerated HPA axis stress responses and poor health outcomes. The aim of this study was to test whether post-stress rumination was related with non-habituation of cortisol to repeated stress exposure. Twenty-seven participants (n=13 females) were exposed to the Trier Social Stress Test (TSST) twice on consecutive afternoons. Post-stress rumination was measured after the first TSST, and HPA axis responses were assessed by measuring salivary cortisol 1 min before, and 1, 10, 20, 60, and 120 min after both TSSTs. Stress exposure induced HPA axis activation on both days, and this activation showed habituation indicated by lower responses to the second TSST (F=3.7, p=0.015). Post-stress rumination after the first TSST was associated with greater cortisol reactivity after the initial stress test (r=0.45, p<0.05) and with increased cortisol responses to the second TSST (r=0.51, p<0.01), indicating non-habituation, independently of age, sex, depressive symptoms, perceived life stress, and trait rumination. In summary, results showed that rumination after stress predicted non-habituation of HPA axis responses. This finding implicates rumination as one possible mechanism mediating maladaptive stress response patterns, and it might also offer a pathway through which rumination might lead to negative health outcomes.

Authors+Show Affiliations

Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, MA, USA.Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, MA, USA.Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, MA, USA.Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, MA, USA.Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, MA, USA.Department of Psychology, Ohio University, Athens, OH, USA.Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, MA, USA. Electronic address: rohleder@brandeis.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25127082

Citation

Gianferante, Danielle, et al. "Post-stress Rumination Predicts HPA Axis Responses to Repeated Acute Stress." Psychoneuroendocrinology, vol. 49, 2014, pp. 244-52.
Gianferante D, Thoma MV, Hanlin L, et al. Post-stress rumination predicts HPA axis responses to repeated acute stress. Psychoneuroendocrinology. 2014;49:244-52.
Gianferante, D., Thoma, M. V., Hanlin, L., Chen, X., Breines, J. G., Zoccola, P. M., & Rohleder, N. (2014). Post-stress rumination predicts HPA axis responses to repeated acute stress. Psychoneuroendocrinology, 49, 244-52. https://doi.org/10.1016/j.psyneuen.2014.07.021
Gianferante D, et al. Post-stress Rumination Predicts HPA Axis Responses to Repeated Acute Stress. Psychoneuroendocrinology. 2014;49:244-52. PubMed PMID: 25127082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-stress rumination predicts HPA axis responses to repeated acute stress. AU - Gianferante,Danielle, AU - Thoma,Myriam V, AU - Hanlin,Luke, AU - Chen,Xuejie, AU - Breines,Juliana G, AU - Zoccola,Peggy M, AU - Rohleder,Nicolas, Y1 - 2014/08/01/ PY - 2014/05/02/received PY - 2014/07/21/revised PY - 2014/07/22/accepted PY - 2014/8/16/entrez PY - 2014/8/16/pubmed PY - 2015/7/4/medline KW - Acute stress KW - Cortisol KW - Habituation KW - Hypothalamic-pituitary-adrenal axis KW - Perseverative cognition KW - Rumination SP - 244 EP - 52 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 49 N2 - Failure of the hypothalamus-pituitary-adrenal (HPA) axis to habituate to repeated stress exposure is related with adverse health outcomes, but our knowledge of predictors of non-habituation is limited. Rumination, defined as repetitive and unwanted past-centered negative thinking, is related with exaggerated HPA axis stress responses and poor health outcomes. The aim of this study was to test whether post-stress rumination was related with non-habituation of cortisol to repeated stress exposure. Twenty-seven participants (n=13 females) were exposed to the Trier Social Stress Test (TSST) twice on consecutive afternoons. Post-stress rumination was measured after the first TSST, and HPA axis responses were assessed by measuring salivary cortisol 1 min before, and 1, 10, 20, 60, and 120 min after both TSSTs. Stress exposure induced HPA axis activation on both days, and this activation showed habituation indicated by lower responses to the second TSST (F=3.7, p=0.015). Post-stress rumination after the first TSST was associated with greater cortisol reactivity after the initial stress test (r=0.45, p<0.05) and with increased cortisol responses to the second TSST (r=0.51, p<0.01), indicating non-habituation, independently of age, sex, depressive symptoms, perceived life stress, and trait rumination. In summary, results showed that rumination after stress predicted non-habituation of HPA axis responses. This finding implicates rumination as one possible mechanism mediating maladaptive stress response patterns, and it might also offer a pathway through which rumination might lead to negative health outcomes. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/25127082/Post_stress_rumination_predicts_HPA_axis_responses_to_repeated_acute_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(14)00297-2 DB - PRIME DP - Unbound Medicine ER -