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Correlation of prostatic urethral angle with the severity of urinary symptom and peak flow rate in men with small prostate volume.
PLoS One. 2014; 9(8):e104395.Plos

Abstract

PURPOSE

To evaluate the effects of prostatic anatomical factors on male lower urinary tract symptoms (LUTS) and the peak flow rate (Qmax) in patients with small prostate volume (PV).

MATERIALS AND METHODS

Records were obtained from a prospectively maintained database of first-visit men with LUTS. Patients whose total PV (TPV) was greater than 30 mL were excluded; 444 patients were enrolled in the study. The TPV, transitional zone volume (TZV), transitional zone index (TZI), intravesical prostatic protrusion (IPP), and prostatic urethral angle (PUA) were measured by transrectal ultrasonography. LUTS were evaluated using the International Prostate Symptom Score (IPSS) and the Overactive Bladder Symptom Score (OABSS) questionnaires. Uroflowmetric measurements were also made.

RESULTS

PUA (r = 0.269, P<0.001), TZV (r = 0.160, P<0.001), and TZI (r = 0.109, P = 0.022) significantly correlated with the IPSS. Qmax (r = -0.334, P<0.001) and OABSS (r = 0.211, P<0.001) correlated only with PUA. In a multivariate regression analysis, PUA and age were independently associated with IPSS, OABSS, and Qmax. For IPSS of 20 or greater, the area under the ROC curve (AUC) of PUA was 0.667 and the cut-off value was 43.7°. When Qmax was 10 mL/s or less, the AUC of PUA was 0.664 and the cut-off value was 43.5°.

CONCLUSIONS

PUA has a significant association with symptom severity and Qmax among prostatic anatomical factors analyzed in men with LUTS and small PV. PUA should be considered as an important clinical factor in male LUTS management. Furthermore, the impact of PUA on response to medical treatment and disease progression needs to be investigated.

Authors+Show Affiliations

Department of Urology, Yangpyeong Health Center, Yangpyeong, Korea.Department of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.Department of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.Department of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.Department of Urology, Severance Check-up, Yonsei University Health System, Seoul, Korea.Department of Urology, Gangnam Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25127394

Citation

Kang, Dong Hyuk, et al. "Correlation of Prostatic Urethral Angle With the Severity of Urinary Symptom and Peak Flow Rate in Men With Small Prostate Volume." PloS One, vol. 9, no. 8, 2014, pp. e104395.
Kang DH, Lee JY, Hah YS, et al. Correlation of prostatic urethral angle with the severity of urinary symptom and peak flow rate in men with small prostate volume. PLoS One. 2014;9(8):e104395.
Kang, D. H., Lee, J. Y., Hah, Y. S., Chung, D. Y., Lee, D. H., & Cho, K. S. (2014). Correlation of prostatic urethral angle with the severity of urinary symptom and peak flow rate in men with small prostate volume. PloS One, 9(8), e104395. https://doi.org/10.1371/journal.pone.0104395
Kang DH, et al. Correlation of Prostatic Urethral Angle With the Severity of Urinary Symptom and Peak Flow Rate in Men With Small Prostate Volume. PLoS One. 2014;9(8):e104395. PubMed PMID: 25127394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of prostatic urethral angle with the severity of urinary symptom and peak flow rate in men with small prostate volume. AU - Kang,Dong Hyuk, AU - Lee,Joo Yong, AU - Hah,Yoon Soo, AU - Chung,Doo Yong, AU - Lee,Dae Hun, AU - Cho,Kang Su, Y1 - 2014/08/15/ PY - 2014/03/14/received PY - 2014/07/12/accepted PY - 2014/8/16/entrez PY - 2014/8/16/pubmed PY - 2015/11/10/medline SP - e104395 EP - e104395 JF - PloS one JO - PLoS One VL - 9 IS - 8 N2 - PURPOSE: To evaluate the effects of prostatic anatomical factors on male lower urinary tract symptoms (LUTS) and the peak flow rate (Qmax) in patients with small prostate volume (PV). MATERIALS AND METHODS: Records were obtained from a prospectively maintained database of first-visit men with LUTS. Patients whose total PV (TPV) was greater than 30 mL were excluded; 444 patients were enrolled in the study. The TPV, transitional zone volume (TZV), transitional zone index (TZI), intravesical prostatic protrusion (IPP), and prostatic urethral angle (PUA) were measured by transrectal ultrasonography. LUTS were evaluated using the International Prostate Symptom Score (IPSS) and the Overactive Bladder Symptom Score (OABSS) questionnaires. Uroflowmetric measurements were also made. RESULTS: PUA (r = 0.269, P<0.001), TZV (r = 0.160, P<0.001), and TZI (r = 0.109, P = 0.022) significantly correlated with the IPSS. Qmax (r = -0.334, P<0.001) and OABSS (r = 0.211, P<0.001) correlated only with PUA. In a multivariate regression analysis, PUA and age were independently associated with IPSS, OABSS, and Qmax. For IPSS of 20 or greater, the area under the ROC curve (AUC) of PUA was 0.667 and the cut-off value was 43.7°. When Qmax was 10 mL/s or less, the AUC of PUA was 0.664 and the cut-off value was 43.5°. CONCLUSIONS: PUA has a significant association with symptom severity and Qmax among prostatic anatomical factors analyzed in men with LUTS and small PV. PUA should be considered as an important clinical factor in male LUTS management. Furthermore, the impact of PUA on response to medical treatment and disease progression needs to be investigated. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25127394/Correlation_of_prostatic_urethral_angle_with_the_severity_of_urinary_symptom_and_peak_flow_rate_in_men_with_small_prostate_volume_ L2 - https://dx.plos.org/10.1371/journal.pone.0104395 DB - PRIME DP - Unbound Medicine ER -