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Simultaneous voltammetric determination of paracetamol and ascorbic acid using a boron-doped diamond electrode modified with Nafion and lead films.
Talanta. 2014 Nov; 129:384-91.T

Abstract

The paper describes the fabrication and application of a novel sensor (a boron-doped diamond electrode modified with Nafion and lead films) for the simultaneous determination of paracetamol and ascorbic acid by differential pulse voltammetry. The main advantage of the lead film and polymer covered boron-doped diamond electrode is that the sensitivity of the stripping responses is increased and the separation of paracetamol and ascorbic acid signals is improved due to the modification of the boron-doped diamond surface by the lead layer. Additionally, the repeatability of paracetamol and ascorbic acid signals is improved by the application of the Nafion film coating. In the presence of oxygen, linear calibration curves were obtained in a wide concentration range from 5×10(-7) to 2×10(-4) mol L(-1) for paracetamol and from 1×10(-6) to 5×10(-4) mol L(-1) for ascorbic acid. The analytical utility of the differential pulse voltammetric method elaborated was tested in the assay of paracetamol and ascorbic acid in commercially available pharmaceutical formulations and the method was validated by high performance liquid chromatography coupled with diode array detector.

Authors+Show Affiliations

Faculty of Chemistry, Department of Analytical Chemistry and Instrumental Analysis, Maria Curie-Skłodowska University, 20-031 Lublin, Poland. Electronic address: ktyszczuk@poczta.umcs.lublin.pl.Faculty of Chemistry, Department of Analytical Chemistry and Instrumental Analysis, Maria Curie-Skłodowska University, 20-031 Lublin, Poland.Chair of Chemistry, Department of Analytical Chemistry, Medical University, 20-093 Lublin, Poland.Chair of Chemistry, Department of Analytical Chemistry, Medical University, 20-093 Lublin, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25127609

Citation

Tyszczuk-Rotko, Katarzyna, et al. "Simultaneous Voltammetric Determination of Paracetamol and Ascorbic Acid Using a Boron-doped Diamond Electrode Modified With Nafion and Lead Films." Talanta, vol. 129, 2014, pp. 384-91.
Tyszczuk-Rotko K, Bęczkowska I, Wójciak-Kosior M, et al. Simultaneous voltammetric determination of paracetamol and ascorbic acid using a boron-doped diamond electrode modified with Nafion and lead films. Talanta. 2014;129:384-91.
Tyszczuk-Rotko, K., Bęczkowska, I., Wójciak-Kosior, M., & Sowa, I. (2014). Simultaneous voltammetric determination of paracetamol and ascorbic acid using a boron-doped diamond electrode modified with Nafion and lead films. Talanta, 129, 384-91. https://doi.org/10.1016/j.talanta.2014.06.023
Tyszczuk-Rotko K, et al. Simultaneous Voltammetric Determination of Paracetamol and Ascorbic Acid Using a Boron-doped Diamond Electrode Modified With Nafion and Lead Films. Talanta. 2014;129:384-91. PubMed PMID: 25127609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous voltammetric determination of paracetamol and ascorbic acid using a boron-doped diamond electrode modified with Nafion and lead films. AU - Tyszczuk-Rotko,Katarzyna, AU - Bęczkowska,Ilona, AU - Wójciak-Kosior,Magdalena, AU - Sowa,Ireneusz, Y1 - 2014/06/19/ PY - 2014/04/10/received PY - 2014/06/02/revised PY - 2014/06/11/accepted PY - 2014/8/17/entrez PY - 2014/8/17/pubmed PY - 2015/6/17/medline KW - Boron-doped diamond electrode KW - Differential pulse voltammetry KW - Nafion and lead films KW - Paracetamol and ascorbic acid determination SP - 384 EP - 91 JF - Talanta JO - Talanta VL - 129 N2 - The paper describes the fabrication and application of a novel sensor (a boron-doped diamond electrode modified with Nafion and lead films) for the simultaneous determination of paracetamol and ascorbic acid by differential pulse voltammetry. The main advantage of the lead film and polymer covered boron-doped diamond electrode is that the sensitivity of the stripping responses is increased and the separation of paracetamol and ascorbic acid signals is improved due to the modification of the boron-doped diamond surface by the lead layer. Additionally, the repeatability of paracetamol and ascorbic acid signals is improved by the application of the Nafion film coating. In the presence of oxygen, linear calibration curves were obtained in a wide concentration range from 5×10(-7) to 2×10(-4) mol L(-1) for paracetamol and from 1×10(-6) to 5×10(-4) mol L(-1) for ascorbic acid. The analytical utility of the differential pulse voltammetric method elaborated was tested in the assay of paracetamol and ascorbic acid in commercially available pharmaceutical formulations and the method was validated by high performance liquid chromatography coupled with diode array detector. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/25127609/Simultaneous_voltammetric_determination_of_paracetamol_and_ascorbic_acid_using_a_boron_doped_diamond_electrode_modified_with_Nafion_and_lead_films_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(14)00479-2 DB - PRIME DP - Unbound Medicine ER -