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Role of microRNAs in the modulation of diabetic retinopathy.
Prog Retin Eye Res. 2014 Nov; 43:92-107.PR

Abstract

Diabetic retinopathy (DR) is the leading cause of vision loss in the working-age adults. It affects a third of diabetics. Diabetic macular edema, an advanced complication of DR, develops in nearly 7% of diabetic patients. MicroRNAs (miRNAs) are a novel group of non-coding small RNAs that post-transcriptionally control gene expression by promoting either degradation or translational repression of target messenger RNA. They are implicated in a large variety of physiological and pathophysiological processes, including glucose homeostasis, angiogenesis and modulation of inflammatory response. MiRNAs also play a critical role in the pathogenesis of diabetes and the related micro- and macrovascular complications. The purpose of this review is to describe the potential role of miRNAs in diabetes and evaluate their implication in DR. MiRNAs involved in the modulation of glucose metabolism (insulin secretion and sensitivity) and MiRNAs playing a role in the pathogenesis of DR with their potential target genes are reviewed. Understanding MiRNAs implication in DR could be helpful for developing new gain- or loss- of -function strategies in order to establish effective treatments and reduce the rate of visual disability due to progression of retinopathy.

Authors+Show Affiliations

Ophthalmology Clinic, Department of Neurological and Visual Science, University of Verona, Verona, Italy.Department of Medicine and Science of Ageing, Eye Clinic, "G. d'Annunzio" University - Chieti-Pescara, Chieti, Italy. Electronic address: l.toto@unich.it.Geriatric Clinic, European Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, and Clinical Research Center - Center of Excellence on Aging (Ce.S.I.), "G. d'Annunzio" University - Chieti-Pescara, Chieti, Italy.Geriatric Clinic, European Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, and Clinical Research Center - Center of Excellence on Aging (Ce.S.I.), "G. d'Annunzio" University - Chieti-Pescara, Chieti, Italy; Institute for Cardiovascular Prevention, Ludwig Maximilians University, Munich, Germany.Department of Medicine and Science of Ageing, Eye Clinic, "G. d'Annunzio" University - Chieti-Pescara, Chieti, Italy.Department of Medicine and Science of Ageing, Eye Clinic, "G. d'Annunzio" University - Chieti-Pescara, Chieti, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25128741

Citation

Mastropasqua, Rodolfo, et al. "Role of microRNAs in the Modulation of Diabetic Retinopathy." Progress in Retinal and Eye Research, vol. 43, 2014, pp. 92-107.
Mastropasqua R, Toto L, Cipollone F, et al. Role of microRNAs in the modulation of diabetic retinopathy. Prog Retin Eye Res. 2014;43:92-107.
Mastropasqua, R., Toto, L., Cipollone, F., Santovito, D., Carpineto, P., & Mastropasqua, L. (2014). Role of microRNAs in the modulation of diabetic retinopathy. Progress in Retinal and Eye Research, 43, 92-107. https://doi.org/10.1016/j.preteyeres.2014.07.003
Mastropasqua R, et al. Role of microRNAs in the Modulation of Diabetic Retinopathy. Prog Retin Eye Res. 2014;43:92-107. PubMed PMID: 25128741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of microRNAs in the modulation of diabetic retinopathy. AU - Mastropasqua,Rodolfo, AU - Toto,Lisa, AU - Cipollone,Francesco, AU - Santovito,Donato, AU - Carpineto,Paolo, AU - Mastropasqua,Leonardo, Y1 - 2014/08/14/ PY - 2014/04/29/received PY - 2014/07/22/revised PY - 2014/07/28/accepted PY - 2014/8/17/entrez PY - 2014/8/17/pubmed PY - 2015/4/8/medline KW - Angiogenesis KW - Diabetes KW - Diabetic retinopathy KW - microRNA SP - 92 EP - 107 JF - Progress in retinal and eye research JO - Prog Retin Eye Res VL - 43 N2 - Diabetic retinopathy (DR) is the leading cause of vision loss in the working-age adults. It affects a third of diabetics. Diabetic macular edema, an advanced complication of DR, develops in nearly 7% of diabetic patients. MicroRNAs (miRNAs) are a novel group of non-coding small RNAs that post-transcriptionally control gene expression by promoting either degradation or translational repression of target messenger RNA. They are implicated in a large variety of physiological and pathophysiological processes, including glucose homeostasis, angiogenesis and modulation of inflammatory response. MiRNAs also play a critical role in the pathogenesis of diabetes and the related micro- and macrovascular complications. The purpose of this review is to describe the potential role of miRNAs in diabetes and evaluate their implication in DR. MiRNAs involved in the modulation of glucose metabolism (insulin secretion and sensitivity) and MiRNAs playing a role in the pathogenesis of DR with their potential target genes are reviewed. Understanding MiRNAs implication in DR could be helpful for developing new gain- or loss- of -function strategies in order to establish effective treatments and reduce the rate of visual disability due to progression of retinopathy. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/25128741/Role_of_microRNAs_in_the_modulation_of_diabetic_retinopathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(14)00043-3 DB - PRIME DP - Unbound Medicine ER -