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miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients.
Neurogenetics. 2014 Oct; 15(4):243-53.N

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive and seriously disabling adult-onset neurological disease. Ninety percent of ALS patients are sporadic cases (sALS) with no clear genetic linkage. Accumulating evidence indicates that various microRNAs (miRNAs), expressed in a spatially and temporally controlled manner in the brain, play a key role in neuronal development. In addition, microRNA dysregulation contributes to some mental disorders and neurodegeneration diseases. In our research, the expression of one selected miRNA, miR-338-3p, which previously we have found over-expressed in blood leukocytes, was studied in several different tissues from sALS patients. For the first time, we detected a specific microRNA disease-related upregulation, miR-338-3p, in blood leukocytes as well in cerebrospinal fluid, serum, and spinal cord from sALS patients. Besides, staining of in situ hybridization showed that the signals of miR-338-3p were localized in the grey matter of spinal cord tissues from sALS autopsied patients. We propose that miRNA profiles found in tissue samples from sALS patients can be relevant to understand sALS pathogenesis and lead to set up effective biomarkers for sALS early diagnosis.

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Authors+Show Affiliations

De Felice B
DISTABIF-Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Naples II, Via Vivaldi 43, 81100, Caserta, Italy, bruna.defelice@unina2.it.
Annunziata A
No affiliation info available
Fiorentino G
No affiliation info available
Borra M
No affiliation info available
Biffali E
No affiliation info available
Coppola C
No affiliation info available
Cotrufo R
No affiliation info available
Brettschneider J
No affiliation info available
Giordana ML
No affiliation info available
Dalmay T
No affiliation info available
Wheeler G
No affiliation info available
D'Alessandro R
No affiliation info available

MeSH

AgedAmyotrophic Lateral SclerosisFemaleHumansMaleMicroRNAsMiddle AgedNeurodegenerative DiseasesSpinal CordUp-Regulation

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25130371

Citation

De Felice, Bruna, et al. "MiR-338-3p Is Over-expressed in Blood, CFS, Serum and Spinal Cord From Sporadic Amyotrophic Lateral Sclerosis Patients." Neurogenetics, vol. 15, no. 4, 2014, pp. 243-53.
De Felice B, Annunziata A, Fiorentino G, et al. MiR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients. Neurogenetics. 2014;15(4):243-53.
De Felice, B., Annunziata, A., Fiorentino, G., Borra, M., Biffali, E., Coppola, C., Cotrufo, R., Brettschneider, J., Giordana, M. L., Dalmay, T., Wheeler, G., & D'Alessandro, R. (2014). MiR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients. Neurogenetics, 15(4), 243-53. https://doi.org/10.1007/s10048-014-0420-2
De Felice B, et al. MiR-338-3p Is Over-expressed in Blood, CFS, Serum and Spinal Cord From Sporadic Amyotrophic Lateral Sclerosis Patients. Neurogenetics. 2014;15(4):243-53. PubMed PMID: 25130371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients. AU - De Felice,Bruna, AU - Annunziata,Anna, AU - Fiorentino,Giuseppe, AU - Borra,Marco, AU - Biffali,Elio, AU - Coppola,Cinzia, AU - Cotrufo,Roberto, AU - Brettschneider,Johannes, AU - Giordana,Maria Luisa, AU - Dalmay,Tamas, AU - Wheeler,Guy, AU - D'Alessandro,Raffaella, Y1 - 2014/08/19/ PY - 2014/04/25/received PY - 2014/08/11/accepted PY - 2014/8/19/entrez PY - 2014/8/19/pubmed PY - 2015/6/11/medline SP - 243 EP - 53 JF - Neurogenetics JO - Neurogenetics VL - 15 IS - 4 N2 - Amyotrophic lateral sclerosis (ALS) is a progressive and seriously disabling adult-onset neurological disease. Ninety percent of ALS patients are sporadic cases (sALS) with no clear genetic linkage. Accumulating evidence indicates that various microRNAs (miRNAs), expressed in a spatially and temporally controlled manner in the brain, play a key role in neuronal development. In addition, microRNA dysregulation contributes to some mental disorders and neurodegeneration diseases. In our research, the expression of one selected miRNA, miR-338-3p, which previously we have found over-expressed in blood leukocytes, was studied in several different tissues from sALS patients. For the first time, we detected a specific microRNA disease-related upregulation, miR-338-3p, in blood leukocytes as well in cerebrospinal fluid, serum, and spinal cord from sALS patients. Besides, staining of in situ hybridization showed that the signals of miR-338-3p were localized in the grey matter of spinal cord tissues from sALS autopsied patients. We propose that miRNA profiles found in tissue samples from sALS patients can be relevant to understand sALS pathogenesis and lead to set up effective biomarkers for sALS early diagnosis. SN - 1364-6753 UR - https://www.unboundmedicine.com/medline/citation/25130371/miR_338_3p_is_over_expressed_in_blood_CFS_serum_and_spinal_cord_from_sporadic_amyotrophic_lateral_sclerosis_patients_ DB - PRIME DP - Unbound Medicine ER -