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Diagnostic value of dilated intercellular space and histopathologic scores in gastroesophageal reflux disease.
Dis Esophagus. 2015 Aug-Sep; 28(6):530-7.DE

Abstract

The aim of this paper is to investigate the diagnostic value of histopathologic score and the dilated intercellular space (DIS) in patients with gastroesophageal reflux disease (GERD) and functional heartburn (FH). Participants with GERD symptoms including reflux esophagitis, non-erosive reflux disease (NERD), Barrett's esophagus (BE), functional heartburn (FH), along with a control group with atypical GERD-like symptom (Sym-C), and asymptomatic healthy volunteers (H-C) were administered GERD questionnaire, and subjected to endoscopy and biopsies, as well as 24-hour pH-impedance monitoring. Biopsies were evaluated using standards from the 2011 Esohisto Project after Hematoxylin-Eosin staining. DIS was measured quantitatively under light microscopy. Among the total of 565 participants with qualified biopsy specimens, the mean DIS of the reflux esophagitis (RE) group was significantly wider compared with the other five groups. DIS in patients with GERD-like symptoms was significantly wider compared with the H-C. No significant differences were observed between NERD and FH. Results from 24-hour pH-impedance monitoring indicated that only the DIS of patients with acid reflux or the amount of acid reflux episodes in patients with DIS was significantly wider compared with patients with nonacid reflux or patients without DIS (P < 0.001). With DIS = 0.9 μm as the cutoff value, the sensitivity and specificity were 62.6% and 54.1%, respectively. Using the total histopathologic score > 3 as the diagnostic criterion, the sensitivity and specificity were 71.7% and 47.4%. DIS is closely associated with GERD and acid reflux. The diagnostic value of histological scores in lower esophagus in GERD is very similar to that of the quantitative measurement of DIS.

Authors+Show Affiliations

Department of Gastroenterolgy, Third Hospital of Peking University, Beijing, China.Department of Gastroenterolgy, Third Hospital of Peking University, Beijing, China.Department of Gastroenterolgy, Third Hospital of Peking University, Beijing, China.Department of Gastroenterolgy, Third Hospital of Peking University, Beijing, China.Department of Gastroenterolgy, Third Hospital of Peking University, Beijing, China.Department of Gastroenterolgy, Third Hospital of Peking University, Beijing, China.Department of Gastroenterolgy, Third Hospital of Peking University, Beijing, China.Department of Gastroenterolgy, Third Hospital of Peking University, Beijing, China.Department of Gastroenterolgy, Third Hospital of Peking University, Beijing, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25130660

Citation

Cui, R, et al. "Diagnostic Value of Dilated Intercellular Space and Histopathologic Scores in Gastroesophageal Reflux Disease." Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus, vol. 28, no. 6, 2015, pp. 530-7.
Cui R, Zhang H, Zhou L, et al. Diagnostic value of dilated intercellular space and histopathologic scores in gastroesophageal reflux disease. Dis Esophagus. 2015;28(6):530-7.
Cui, R., Zhang, H., Zhou, L., Lu, J., Xue, Y., Wang, Y., Yan, X., Lin, L., & Lin, S. (2015). Diagnostic value of dilated intercellular space and histopathologic scores in gastroesophageal reflux disease. Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus, 28(6), 530-7. https://doi.org/10.1111/dote.12256
Cui R, et al. Diagnostic Value of Dilated Intercellular Space and Histopathologic Scores in Gastroesophageal Reflux Disease. Dis Esophagus. 2015;28(6):530-7. PubMed PMID: 25130660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of dilated intercellular space and histopathologic scores in gastroesophageal reflux disease. AU - Cui,R, AU - Zhang,H, AU - Zhou,L, AU - Lu,J, AU - Xue,Y, AU - Wang,Y, AU - Yan,X, AU - Lin,L, AU - Lin,S, Y1 - 2014/08/18/ PY - 2014/8/19/entrez PY - 2014/8/19/pubmed PY - 2016/5/26/medline KW - 24-hour pH-impedance monitoring KW - dilated intercellular space KW - functional heartburn KW - gastroesophageal reflux disease KW - histopathology SP - 530 EP - 7 JF - Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus JO - Dis. Esophagus VL - 28 IS - 6 N2 - The aim of this paper is to investigate the diagnostic value of histopathologic score and the dilated intercellular space (DIS) in patients with gastroesophageal reflux disease (GERD) and functional heartburn (FH). Participants with GERD symptoms including reflux esophagitis, non-erosive reflux disease (NERD), Barrett's esophagus (BE), functional heartburn (FH), along with a control group with atypical GERD-like symptom (Sym-C), and asymptomatic healthy volunteers (H-C) were administered GERD questionnaire, and subjected to endoscopy and biopsies, as well as 24-hour pH-impedance monitoring. Biopsies were evaluated using standards from the 2011 Esohisto Project after Hematoxylin-Eosin staining. DIS was measured quantitatively under light microscopy. Among the total of 565 participants with qualified biopsy specimens, the mean DIS of the reflux esophagitis (RE) group was significantly wider compared with the other five groups. DIS in patients with GERD-like symptoms was significantly wider compared with the H-C. No significant differences were observed between NERD and FH. Results from 24-hour pH-impedance monitoring indicated that only the DIS of patients with acid reflux or the amount of acid reflux episodes in patients with DIS was significantly wider compared with patients with nonacid reflux or patients without DIS (P < 0.001). With DIS = 0.9 μm as the cutoff value, the sensitivity and specificity were 62.6% and 54.1%, respectively. Using the total histopathologic score > 3 as the diagnostic criterion, the sensitivity and specificity were 71.7% and 47.4%. DIS is closely associated with GERD and acid reflux. The diagnostic value of histological scores in lower esophagus in GERD is very similar to that of the quantitative measurement of DIS. SN - 1442-2050 UR - https://www.unboundmedicine.com/medline/citation/25130660/Diagnostic_value_of_dilated_intercellular_space_and_histopathologic_scores_in_gastroesophageal_reflux_disease_ L2 - https://academic.oup.com/dote/article-lookup/doi/10.1111/dote.12256 DB - PRIME DP - Unbound Medicine ER -