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Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers.
Am J Obstet Gynecol. 2015 Feb; 212(2):227.e1-7.AJ

Abstract

OBJECTIVE

Obese women are at increased risk to deliver a large infant, however, the underlying mechanisms are poorly understood. Fetal glucose availability is critically dependent on placental transfer and is linked to fetal growth by regulating the release of fetal growth hormones such as insulin. We hypothesized that (1) umbilical vein glucose and insulin levels and (2) placental glucose transporter (GLUT) expression and activity are positively correlated with early pregnancy maternal body mass index and infant birthweight.

STUDY DESIGN

Subjects in this prospective observational cohort study were nondiabetic predominantly Hispanic women delivered at term. Fasting maternal and umbilical vein glucose and insulin concentrations were determined in 29 women with varying early pregnancy body mass index (range, 18.0-54.3) who delivered infants with birthweights ranging from 2800-4402 g. We isolated syncytiotrophoblast microvillous and basal plasma membranes from 33 placentas and determined the expression of GLUT-1 and -9 (Western blot) and glucose uptake (radiolabeled glucose).

RESULTS

Birthweight was positively correlated with umbilical vein glucose and insulin and maternal body mass index. Umbilical vein glucose levels were positively correlated with placental weight and maternal body mass index, but not with maternal fasting glucose. Basal plasma membranes GLUT-1 expression was positively correlated with birthweight. In contrast, syncytiotrophoblast microvillous GLUT-1 and -9, basal plasma membranes GLUT-9 expression and syncytiotrophoblast microvillous and basal plasma membranes glucose transport activity were not correlated with birthweight.

CONCLUSION

Because maternal fasting glucose levels and placental glucose transport capacity were not increased in obese women delivering larger infants, we speculate that increased placental size promotes glucose delivery to these fetuses.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX. Electronic address: acostao@uthscsa.edu.Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX.Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX.Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX.Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX.Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX.Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX.

Pub Type(s)

Journal Article
Observational Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25132463

Citation

Acosta, Ometeotl, et al. "Increased Glucose and Placental GLUT-1 in Large Infants of Obese Nondiabetic Mothers." American Journal of Obstetrics and Gynecology, vol. 212, no. 2, 2015, pp. 227.e1-7.
Acosta O, Ramirez VI, Lager S, et al. Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. Am J Obstet Gynecol. 2015;212(2):227.e1-7.
Acosta, O., Ramirez, V. I., Lager, S., Gaccioli, F., Dudley, D. J., Powell, T. L., & Jansson, T. (2015). Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. American Journal of Obstetrics and Gynecology, 212(2), e1-7. https://doi.org/10.1016/j.ajog.2014.08.009
Acosta O, et al. Increased Glucose and Placental GLUT-1 in Large Infants of Obese Nondiabetic Mothers. Am J Obstet Gynecol. 2015;212(2):227.e1-7. PubMed PMID: 25132463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. AU - Acosta,Ometeotl, AU - Ramirez,Vanessa I, AU - Lager,Susanne, AU - Gaccioli,Francesca, AU - Dudley,Donald J, AU - Powell,Theresa L, AU - Jansson,Thomas, Y1 - 2014/08/14/ PY - 2014/03/28/received PY - 2014/06/14/revised PY - 2014/08/12/accepted PY - 2014/8/19/entrez PY - 2014/8/19/pubmed PY - 2015/4/9/medline KW - fetal growth KW - maternal obesity KW - maternal-fetal exchange KW - trophoblast SP - 227.e1 EP - 7 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 212 IS - 2 N2 - OBJECTIVE: Obese women are at increased risk to deliver a large infant, however, the underlying mechanisms are poorly understood. Fetal glucose availability is critically dependent on placental transfer and is linked to fetal growth by regulating the release of fetal growth hormones such as insulin. We hypothesized that (1) umbilical vein glucose and insulin levels and (2) placental glucose transporter (GLUT) expression and activity are positively correlated with early pregnancy maternal body mass index and infant birthweight. STUDY DESIGN: Subjects in this prospective observational cohort study were nondiabetic predominantly Hispanic women delivered at term. Fasting maternal and umbilical vein glucose and insulin concentrations were determined in 29 women with varying early pregnancy body mass index (range, 18.0-54.3) who delivered infants with birthweights ranging from 2800-4402 g. We isolated syncytiotrophoblast microvillous and basal plasma membranes from 33 placentas and determined the expression of GLUT-1 and -9 (Western blot) and glucose uptake (radiolabeled glucose). RESULTS: Birthweight was positively correlated with umbilical vein glucose and insulin and maternal body mass index. Umbilical vein glucose levels were positively correlated with placental weight and maternal body mass index, but not with maternal fasting glucose. Basal plasma membranes GLUT-1 expression was positively correlated with birthweight. In contrast, syncytiotrophoblast microvillous GLUT-1 and -9, basal plasma membranes GLUT-9 expression and syncytiotrophoblast microvillous and basal plasma membranes glucose transport activity were not correlated with birthweight. CONCLUSION: Because maternal fasting glucose levels and placental glucose transport capacity were not increased in obese women delivering larger infants, we speculate that increased placental size promotes glucose delivery to these fetuses. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/25132463/Increased_glucose_and_placental_GLUT_1_in_large_infants_of_obese_nondiabetic_mothers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(14)00840-0 DB - PRIME DP - Unbound Medicine ER -