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Pre- and postnatal exposure to parental smoking and allergic disease through adolescence.
Pediatrics 2014; 134(3):428-34Ped

Abstract

OBJECTIVES

To examine the role of prenatal and postnatal second-hand tobacco smoke (SHS) exposure on asthma, rhinitis, and eczema development up to 16 years of age.

METHODS

A birth cohort of 4089 children was followed for 16 years. Information on parental smoking habits, lifestyle factors, and symptoms of allergic disease was gathered using repeated parental questionnaires. Generalized estimating equations assessed the overall and age-specific associations between SHS exposure and allergic disease at ages 1 to 16 years.

RESULTS

Exposure to SHS in utero was associated with an overall elevated risk of developing asthma up to 16 years (odds ratio [OR] = 1.45; 95% confidence interval [CI], 1.15-1.83) but not for rhinitis or eczema. After additional adjustment for parental smoking throughout childhood, excess overall risks for asthma remained statistically significant. Moreover, a dose-dependent pattern with SHS was observed. Exposure to SHS during infancy was associated with an overall elevated risk of asthma (OR = 1.23; 95% CI, 1.01-1.51), rhinitis (OR = 1.18; 95% CI, 1.01-1.39), and eczema (OR = 1.26; 95% CI, 1.09-1.45) up to 16 years. When age-specific associations were examined, the elevated risks related to SHS exposure in utero or during infancy were mostly confined to early childhood for asthma and rhinitis, whereas the excess risk of eczema appeared greatest at later ages.

CONCLUSIONS

Our findings indicate that early SHS exposure, in utero or during infancy, influences the development of allergic disease up to adolescence. Excess risks for asthma and rhinitis were seen primarily in early childhood, whereas those for eczema occurred at later ages.

Authors+Show Affiliations

Institute of Environmental Medicine, and jesse.thacher@ki.se.Institute of Environmental Medicine, and.Institute of Environmental Medicine, and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden;Institute of Environmental Medicine, and Department of Women's and Children's Health, Uppsala University Hospital, Uppsala, Sweden; and.Institute of Environmental Medicine, and Sachs' Children's Hospital, Södersjukhuset, Stockholm, Sweden.Institute of Environmental Medicine, and Sachs' Children's Hospital, Södersjukhuset, Stockholm, Sweden Department of Clinical Science and Education, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden;Institute of Environmental Medicine, and Sachs' Children's Hospital, Södersjukhuset, Stockholm, Sweden.Institute of Environmental Medicine, and.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25136039

Citation

Thacher, Jesse D., et al. "Pre- and Postnatal Exposure to Parental Smoking and Allergic Disease Through Adolescence." Pediatrics, vol. 134, no. 3, 2014, pp. 428-34.
Thacher JD, Gruzieva O, Pershagen G, et al. Pre- and postnatal exposure to parental smoking and allergic disease through adolescence. Pediatrics. 2014;134(3):428-34.
Thacher, J. D., Gruzieva, O., Pershagen, G., Neuman, Å., Wickman, M., Kull, I., ... Bergström, A. (2014). Pre- and postnatal exposure to parental smoking and allergic disease through adolescence. Pediatrics, 134(3), pp. 428-34. doi:10.1542/peds.2014-0427.
Thacher JD, et al. Pre- and Postnatal Exposure to Parental Smoking and Allergic Disease Through Adolescence. Pediatrics. 2014;134(3):428-34. PubMed PMID: 25136039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre- and postnatal exposure to parental smoking and allergic disease through adolescence. AU - Thacher,Jesse D, AU - Gruzieva,Olena, AU - Pershagen,Göran, AU - Neuman,Åsa, AU - Wickman,Magnus, AU - Kull,Inger, AU - Melén,Erik, AU - Bergström,Anna, PY - 2014/8/20/entrez PY - 2014/8/20/pubmed PY - 2014/10/31/medline KW - allergy KW - asthma KW - children KW - cohort study KW - eczema KW - rhinitis KW - tobacco smoking SP - 428 EP - 34 JF - Pediatrics JO - Pediatrics VL - 134 IS - 3 N2 - OBJECTIVES: To examine the role of prenatal and postnatal second-hand tobacco smoke (SHS) exposure on asthma, rhinitis, and eczema development up to 16 years of age. METHODS: A birth cohort of 4089 children was followed for 16 years. Information on parental smoking habits, lifestyle factors, and symptoms of allergic disease was gathered using repeated parental questionnaires. Generalized estimating equations assessed the overall and age-specific associations between SHS exposure and allergic disease at ages 1 to 16 years. RESULTS: Exposure to SHS in utero was associated with an overall elevated risk of developing asthma up to 16 years (odds ratio [OR] = 1.45; 95% confidence interval [CI], 1.15-1.83) but not for rhinitis or eczema. After additional adjustment for parental smoking throughout childhood, excess overall risks for asthma remained statistically significant. Moreover, a dose-dependent pattern with SHS was observed. Exposure to SHS during infancy was associated with an overall elevated risk of asthma (OR = 1.23; 95% CI, 1.01-1.51), rhinitis (OR = 1.18; 95% CI, 1.01-1.39), and eczema (OR = 1.26; 95% CI, 1.09-1.45) up to 16 years. When age-specific associations were examined, the elevated risks related to SHS exposure in utero or during infancy were mostly confined to early childhood for asthma and rhinitis, whereas the excess risk of eczema appeared greatest at later ages. CONCLUSIONS: Our findings indicate that early SHS exposure, in utero or during infancy, influences the development of allergic disease up to adolescence. Excess risks for asthma and rhinitis were seen primarily in early childhood, whereas those for eczema occurred at later ages. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/25136039/Pre__and_postnatal_exposure_to_parental_smoking_and_allergic_disease_through_adolescence_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=25136039 DB - PRIME DP - Unbound Medicine ER -