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High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS).

Abstract

C-reactive protein (CRP) is a risk marker for type 2 diabetes mellitus and cardiovascular diseases. In polycystic ovary syndrome (PCOS), limited data are available on high-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of PCOS especially in Indian women. The objective was to determine serum hs-CRP concentration in adolescent women with and without PCOS and to assess possible correlations of serum hs-CRP levels with components of PCOS in Indian women. One hundred and sixty women with PCOS and sixty non-PCOS women having normal menstrual cycles were included. Clinical assessment included anthropometry, Ferriman-Gallwey (FG) score and blood pressure (BP) measurement. Laboratory evaluation included estimation of T4, TSH, LH, FSH, total testosterone, prolactin, cortisol, 17OHP, hs-CRP, lipid profile, and insulin, and glucose after 2-h oral glucose tolerance test. Homeostasis Model Assessment Insulin resistance index (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) and glucose intolerance was calculated. FG score, LH, FSH, total Testosterone, HOMA-IR and QUICKI were significantly different among women with or without PCOS (p < 0.01). Although hs-CRP levels showed a higher trend in women having PCOS, there was no significant difference between the groups (p > 0.05). A significant and positive correlation was found between hs-CRP and body mass index (BMI) (r = 0.308, p < 0.01) among PCOS group. The results in Indian adolescent women suggest that hs-CRP levels may not per se be associated with PCOS, rather can be related to fat mass in this subset of subjects.

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  • Authors+Show Affiliations

    ,

    Department of Endocrinology and Metabolism, All India Institute of Medical Sciences , New Delhi , India .

    , , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Blood Glucose
    Body Mass Index
    C-Reactive Protein
    Cardiovascular Diseases
    Diabetes Mellitus, Type 2
    Female
    Follicle Stimulating Hormone
    Glucose Tolerance Test
    Humans
    India
    Insulin
    Insulin Resistance
    Lipids
    Luteinizing Hormone
    Obesity
    Polycystic Ovary Syndrome
    Risk Factors
    Testosterone
    Thyroid Hormones
    Young Adult

    Pub Type(s)

    Journal Article
    Observational Study

    Language

    eng

    PubMed ID

    25137507

    Citation

    Ganie, Mohd Ashraf, et al. "High-sensitivity C-reactive Protein (hs-CRP) Levels and Its Relationship With Components of Polycystic Ovary Syndrome in Indian Adolescent Women With Polycystic Ovary Syndrome (PCOS)." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 30, no. 11, 2014, pp. 781-4.
    Ganie MA, Hassan S, Nisar S, et al. High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS). Gynecol Endocrinol. 2014;30(11):781-4.
    Ganie, M. A., Hassan, S., Nisar, S., Shamas, N., Rashid, A., Ahmed, I., ... Rashid, F. (2014). High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS). Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 30(11), pp. 781-4. doi:10.3109/09513590.2014.924099.
    Ganie MA, et al. High-sensitivity C-reactive Protein (hs-CRP) Levels and Its Relationship With Components of Polycystic Ovary Syndrome in Indian Adolescent Women With Polycystic Ovary Syndrome (PCOS). Gynecol Endocrinol. 2014;30(11):781-4. PubMed PMID: 25137507.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS). AU - Ganie,Mohd Ashraf, AU - Hassan,Saqib, AU - Nisar,Sobia, AU - Shamas,Nasir, AU - Rashid,Aafia, AU - Ahmed,Ishfaq, AU - Douhat,Syed, AU - Mudassar,Syed, AU - Jan,Vicar M, AU - Rashid,Fouzia, Y1 - 2014/08/19/ PY - 2014/8/20/entrez PY - 2014/8/20/pubmed PY - 2015/6/25/medline KW - Body mass index KW - Ferriman–Gallwey score KW - HOMA-IR KW - hs C-reactive protein KW - insulin resistance KW - obesity KW - polycystic ovary syndrome KW - testosterone SP - 781 EP - 4 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 30 IS - 11 N2 - C-reactive protein (CRP) is a risk marker for type 2 diabetes mellitus and cardiovascular diseases. In polycystic ovary syndrome (PCOS), limited data are available on high-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of PCOS especially in Indian women. The objective was to determine serum hs-CRP concentration in adolescent women with and without PCOS and to assess possible correlations of serum hs-CRP levels with components of PCOS in Indian women. One hundred and sixty women with PCOS and sixty non-PCOS women having normal menstrual cycles were included. Clinical assessment included anthropometry, Ferriman-Gallwey (FG) score and blood pressure (BP) measurement. Laboratory evaluation included estimation of T4, TSH, LH, FSH, total testosterone, prolactin, cortisol, 17OHP, hs-CRP, lipid profile, and insulin, and glucose after 2-h oral glucose tolerance test. Homeostasis Model Assessment Insulin resistance index (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) and glucose intolerance was calculated. FG score, LH, FSH, total Testosterone, HOMA-IR and QUICKI were significantly different among women with or without PCOS (p < 0.01). Although hs-CRP levels showed a higher trend in women having PCOS, there was no significant difference between the groups (p > 0.05). A significant and positive correlation was found between hs-CRP and body mass index (BMI) (r = 0.308, p < 0.01) among PCOS group. The results in Indian adolescent women suggest that hs-CRP levels may not per se be associated with PCOS, rather can be related to fat mass in this subset of subjects. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/25137507/High_sensitivity_C_reactive_protein__hs_CRP__levels_and_its_relationship_with_components_of_polycystic_ovary_syndrome_in_Indian_adolescent_women_with_polycystic_ovary_syndrome__PCOS__ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2014.924099 DB - PRIME DP - Unbound Medicine ER -