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High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS).
Gynecol Endocrinol 2014; 30(11):781-4GE

Abstract

C-reactive protein (CRP) is a risk marker for type 2 diabetes mellitus and cardiovascular diseases. In polycystic ovary syndrome (PCOS), limited data are available on high-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of PCOS especially in Indian women. The objective was to determine serum hs-CRP concentration in adolescent women with and without PCOS and to assess possible correlations of serum hs-CRP levels with components of PCOS in Indian women. One hundred and sixty women with PCOS and sixty non-PCOS women having normal menstrual cycles were included. Clinical assessment included anthropometry, Ferriman-Gallwey (FG) score and blood pressure (BP) measurement. Laboratory evaluation included estimation of T4, TSH, LH, FSH, total testosterone, prolactin, cortisol, 17OHP, hs-CRP, lipid profile, and insulin, and glucose after 2-h oral glucose tolerance test. Homeostasis Model Assessment Insulin resistance index (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) and glucose intolerance was calculated. FG score, LH, FSH, total Testosterone, HOMA-IR and QUICKI were significantly different among women with or without PCOS (p < 0.01). Although hs-CRP levels showed a higher trend in women having PCOS, there was no significant difference between the groups (p > 0.05). A significant and positive correlation was found between hs-CRP and body mass index (BMI) (r = 0.308, p < 0.01) among PCOS group. The results in Indian adolescent women suggest that hs-CRP levels may not per se be associated with PCOS, rather can be related to fat mass in this subset of subjects.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, All India Institute of Medical Sciences , New Delhi , India .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

25137507

Citation

Ganie, Mohd Ashraf, et al. "High-sensitivity C-reactive Protein (hs-CRP) Levels and Its Relationship With Components of Polycystic Ovary Syndrome in Indian Adolescent Women With Polycystic Ovary Syndrome (PCOS)." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 30, no. 11, 2014, pp. 781-4.
Ganie MA, Hassan S, Nisar S, et al. High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS). Gynecol Endocrinol. 2014;30(11):781-4.
Ganie, M. A., Hassan, S., Nisar, S., Shamas, N., Rashid, A., Ahmed, I., ... Rashid, F. (2014). High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS). Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 30(11), pp. 781-4. doi:10.3109/09513590.2014.924099.
Ganie MA, et al. High-sensitivity C-reactive Protein (hs-CRP) Levels and Its Relationship With Components of Polycystic Ovary Syndrome in Indian Adolescent Women With Polycystic Ovary Syndrome (PCOS). Gynecol Endocrinol. 2014;30(11):781-4. PubMed PMID: 25137507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS). AU - Ganie,Mohd Ashraf, AU - Hassan,Saqib, AU - Nisar,Sobia, AU - Shamas,Nasir, AU - Rashid,Aafia, AU - Ahmed,Ishfaq, AU - Douhat,Syed, AU - Mudassar,Syed, AU - Jan,Vicar M, AU - Rashid,Fouzia, Y1 - 2014/08/19/ PY - 2014/8/20/entrez PY - 2014/8/20/pubmed PY - 2015/6/25/medline KW - Body mass index KW - Ferriman–Gallwey score KW - HOMA-IR KW - hs C-reactive protein KW - insulin resistance KW - obesity KW - polycystic ovary syndrome KW - testosterone SP - 781 EP - 4 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 30 IS - 11 N2 - C-reactive protein (CRP) is a risk marker for type 2 diabetes mellitus and cardiovascular diseases. In polycystic ovary syndrome (PCOS), limited data are available on high-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of PCOS especially in Indian women. The objective was to determine serum hs-CRP concentration in adolescent women with and without PCOS and to assess possible correlations of serum hs-CRP levels with components of PCOS in Indian women. One hundred and sixty women with PCOS and sixty non-PCOS women having normal menstrual cycles were included. Clinical assessment included anthropometry, Ferriman-Gallwey (FG) score and blood pressure (BP) measurement. Laboratory evaluation included estimation of T4, TSH, LH, FSH, total testosterone, prolactin, cortisol, 17OHP, hs-CRP, lipid profile, and insulin, and glucose after 2-h oral glucose tolerance test. Homeostasis Model Assessment Insulin resistance index (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) and glucose intolerance was calculated. FG score, LH, FSH, total Testosterone, HOMA-IR and QUICKI were significantly different among women with or without PCOS (p < 0.01). Although hs-CRP levels showed a higher trend in women having PCOS, there was no significant difference between the groups (p > 0.05). A significant and positive correlation was found between hs-CRP and body mass index (BMI) (r = 0.308, p < 0.01) among PCOS group. The results in Indian adolescent women suggest that hs-CRP levels may not per se be associated with PCOS, rather can be related to fat mass in this subset of subjects. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/25137507/High_sensitivity_C_reactive_protein__hs_CRP__levels_and_its_relationship_with_components_of_polycystic_ovary_syndrome_in_Indian_adolescent_women_with_polycystic_ovary_syndrome__PCOS__ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2014.924099 DB - PRIME DP - Unbound Medicine ER -