TY - JOUR T1 - High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS). AU - Ganie,Mohd Ashraf, AU - Hassan,Saqib, AU - Nisar,Sobia, AU - Shamas,Nasir, AU - Rashid,Aafia, AU - Ahmed,Ishfaq, AU - Douhat,Syed, AU - Mudassar,Syed, AU - Jan,Vicar M, AU - Rashid,Fouzia, Y1 - 2014/08/19/ PY - 2014/8/20/entrez PY - 2014/8/20/pubmed PY - 2015/6/25/medline KW - Body mass index KW - Ferriman–Gallwey score KW - HOMA-IR KW - hs C-reactive protein KW - insulin resistance KW - obesity KW - polycystic ovary syndrome KW - testosterone SP - 781 EP - 4 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 30 IS - 11 N2 - C-reactive protein (CRP) is a risk marker for type 2 diabetes mellitus and cardiovascular diseases. In polycystic ovary syndrome (PCOS), limited data are available on high-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of PCOS especially in Indian women. The objective was to determine serum hs-CRP concentration in adolescent women with and without PCOS and to assess possible correlations of serum hs-CRP levels with components of PCOS in Indian women. One hundred and sixty women with PCOS and sixty non-PCOS women having normal menstrual cycles were included. Clinical assessment included anthropometry, Ferriman-Gallwey (FG) score and blood pressure (BP) measurement. Laboratory evaluation included estimation of T4, TSH, LH, FSH, total testosterone, prolactin, cortisol, 17OHP, hs-CRP, lipid profile, and insulin, and glucose after 2-h oral glucose tolerance test. Homeostasis Model Assessment Insulin resistance index (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) and glucose intolerance was calculated. FG score, LH, FSH, total Testosterone, HOMA-IR and QUICKI were significantly different among women with or without PCOS (p < 0.01). Although hs-CRP levels showed a higher trend in women having PCOS, there was no significant difference between the groups (p > 0.05). A significant and positive correlation was found between hs-CRP and body mass index (BMI) (r = 0.308, p < 0.01) among PCOS group. The results in Indian adolescent women suggest that hs-CRP levels may not per se be associated with PCOS, rather can be related to fat mass in this subset of subjects. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/25137507/High_sensitivity_C_reactive_protein__hs_CRP__levels_and_its_relationship_with_components_of_polycystic_ovary_syndrome_in_Indian_adolescent_women_with_polycystic_ovary_syndrome__PCOS__ DB - PRIME DP - Unbound Medicine ER -