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Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population.
BMC Cardiovasc Disord. 2014 Aug 20; 14:105.BC

Abstract

BACKGROUND

Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population.

METHODS

We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.

RESULTS

The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively.

CONCLUSIONS

MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.

Authors+Show Affiliations

No affiliation info availableDivision of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, Republic of Korea. hjchang@yuhs.ac.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25138993

Citation

Won, Ki-Bum, et al. "Differential Association Between Metabolic Syndrome and Coronary Artery Disease Evaluated With Cardiac Computed Tomography According to the Presence of Diabetes in a Symptomatic Korean Population." BMC Cardiovascular Disorders, vol. 14, 2014, p. 105.
Won KB, Chang HJ, Sung J, et al. Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population. BMC Cardiovasc Disord. 2014;14:105.
Won, K. B., Chang, H. J., Sung, J., Shin, S., Cho, I. J., Shim, C. Y., Hong, G. R., Kim, Y. J., Choi, B. W., & Chung, N. (2014). Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population. BMC Cardiovascular Disorders, 14, 105. https://doi.org/10.1186/1471-2261-14-105
Won KB, et al. Differential Association Between Metabolic Syndrome and Coronary Artery Disease Evaluated With Cardiac Computed Tomography According to the Presence of Diabetes in a Symptomatic Korean Population. BMC Cardiovasc Disord. 2014 Aug 20;14:105. PubMed PMID: 25138993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population. AU - Won,Ki-Bum, AU - Chang,Hyuk-Jae, AU - Sung,Jimin, AU - Shin,Sanghoon, AU - Cho,In-Jeong, AU - Shim,Chi-Young, AU - Hong,Geu-Ru, AU - Kim,Young Jin, AU - Choi,Byung-Wook, AU - Chung,Namsik, Y1 - 2014/08/20/ PY - 2014/03/17/received PY - 2014/08/13/accepted PY - 2014/8/21/entrez PY - 2014/8/21/pubmed PY - 2015/1/21/medline SP - 105 EP - 105 JF - BMC cardiovascular disorders JO - BMC Cardiovasc Disord VL - 14 N2 - BACKGROUND: Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population. METHODS: We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography. RESULTS: The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively. CONCLUSIONS: MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population. SN - 1471-2261 UR - https://www.unboundmedicine.com/medline/citation/25138993/Differential_association_between_metabolic_syndrome_and_coronary_artery_disease_evaluated_with_cardiac_computed_tomography_according_to_the_presence_of_diabetes_in_a_symptomatic_Korean_population_ L2 - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-14-105 DB - PRIME DP - Unbound Medicine ER -