Tags

Type your tag names separated by a space and hit enter

[Efficacy of levetiracetam combined with short-term clonazepam in treatment of electrical status epilepticus during sleep in children with benign childhood epilepsy with centrotemporal spikes].
Zhongguo Dang Dai Er Ke Za Zhi. 2014 Aug; 16(8):829-33.ZD

Abstract

OBJECTIVE

To study the efficacy of levetiracetam (LEV) combined with short-term clonazepam (CZP) in the treatment of electrical status epilepticus during sleep (ESES) in children with benign childhood epilepsy with centrotemporal spikes (BECCT).

METHODS

Fifteen children (9 boys and 6 girls) diagnosed with BECCT with ESES, who had continuous spike-and-wave accounting for over 85% of the non-rapid eye movement sleep as monitored by 24-hours ambulatory EEG or 3-hours video EEG, were enrolled. The clinical manifestations and EEG characteristics of patients were retrospectively analyzed. These children received two months of CZP treatment in addition to oral LEV [20-40 mg/(kg·d)]. All patients were followed up for 6-18 months.

RESULTS

The 15 children were orally given LEV in the early stage, but showed no improvement when reexamined by EEG or had seizures during treatment. Then, they received LEV in combination with short-term CZP. Re-examinations at 1 and 6 months after treatment showed that 14 cases had significantly reduced discharge (only little discharge in the Rolandic area) or no discharge, as well as completely controlled seizure; one case had recurrent ESES and two epileptic seizures during follow-up. The recurrent case received the combination therapy again, and re-examinations 1 and 6 months later revealed normal EEG; no seizure occurred in the 8 months of follow-up.

CONCLUSIONS

LEV combined with short-term CZP is effective and has few side effects in treating ESES syndrome among children with BECCT.

Authors+Show Affiliations

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. sanqingx@163.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

25140777

Citation

Su, Tang-Feng, et al. "[Efficacy of Levetiracetam Combined With Short-term Clonazepam in Treatment of Electrical Status Epilepticus During Sleep in Children With Benign Childhood Epilepsy With Centrotemporal Spikes]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 16, no. 8, 2014, pp. 829-33.
Su TF, Xu SQ, Chen L. [Efficacy of levetiracetam combined with short-term clonazepam in treatment of electrical status epilepticus during sleep in children with benign childhood epilepsy with centrotemporal spikes]. Zhongguo Dang Dai Er Ke Za Zhi. 2014;16(8):829-33.
Su, T. F., Xu, S. Q., & Chen, L. (2014). [Efficacy of levetiracetam combined with short-term clonazepam in treatment of electrical status epilepticus during sleep in children with benign childhood epilepsy with centrotemporal spikes]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 16(8), 829-33.
Su TF, Xu SQ, Chen L. [Efficacy of Levetiracetam Combined With Short-term Clonazepam in Treatment of Electrical Status Epilepticus During Sleep in Children With Benign Childhood Epilepsy With Centrotemporal Spikes]. Zhongguo Dang Dai Er Ke Za Zhi. 2014;16(8):829-33. PubMed PMID: 25140777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Efficacy of levetiracetam combined with short-term clonazepam in treatment of electrical status epilepticus during sleep in children with benign childhood epilepsy with centrotemporal spikes]. AU - Su,Tang-Feng, AU - Xu,San-Qing, AU - Chen,Ling, PY - 2014/8/21/entrez PY - 2014/8/21/pubmed PY - 2015/1/30/medline SP - 829 EP - 33 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 16 IS - 8 N2 - OBJECTIVE: To study the efficacy of levetiracetam (LEV) combined with short-term clonazepam (CZP) in the treatment of electrical status epilepticus during sleep (ESES) in children with benign childhood epilepsy with centrotemporal spikes (BECCT). METHODS: Fifteen children (9 boys and 6 girls) diagnosed with BECCT with ESES, who had continuous spike-and-wave accounting for over 85% of the non-rapid eye movement sleep as monitored by 24-hours ambulatory EEG or 3-hours video EEG, were enrolled. The clinical manifestations and EEG characteristics of patients were retrospectively analyzed. These children received two months of CZP treatment in addition to oral LEV [20-40 mg/(kg·d)]. All patients were followed up for 6-18 months. RESULTS: The 15 children were orally given LEV in the early stage, but showed no improvement when reexamined by EEG or had seizures during treatment. Then, they received LEV in combination with short-term CZP. Re-examinations at 1 and 6 months after treatment showed that 14 cases had significantly reduced discharge (only little discharge in the Rolandic area) or no discharge, as well as completely controlled seizure; one case had recurrent ESES and two epileptic seizures during follow-up. The recurrent case received the combination therapy again, and re-examinations 1 and 6 months later revealed normal EEG; no seizure occurred in the 8 months of follow-up. CONCLUSIONS: LEV combined with short-term CZP is effective and has few side effects in treating ESES syndrome among children with BECCT. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/25140777/[Efficacy_of_levetiracetam_combined_with_short_term_clonazepam_in_treatment_of_electrical_status_epilepticus_during_sleep_in_children_with_benign_childhood_epilepsy_with_centrotemporal_spikes]_ L2 - http://www.zgddek.com/EN/abstract/abstract13437.shtml DB - PRIME DP - Unbound Medicine ER -