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[Significance of 2-hour blood glucose after standardized steamed bread meal in diabetic screening].
Zhonghua Yi Xue Za Zhi. 2014 May 13; 94(18):1388-92.ZY

Abstract

OBJECTIVE

To explore the significance of 2-hour blood glucose after standardized steamed bread meal (SB-2 hBG) in diabetic screening.

METHODS

A retrospective study was conducted for diabetic screening data of annual check-up at PLA General Hospital from May 1996 to June 2002. And 100 g standardized steamed bread meal test was performed for non-diabetic subjects. Those subjects with SB-2 h BG ≥ 7.2 mmol/L underwent a 75 g oral glucose tolerance test (OGTT) within 2 weeks to determine whether the diagnosis of diabetes mellitus (DM) could be established (WHO, 1985, 1999, Diagnostic Criteria for Diabetes). By extracting the data for 7 consecutive years, we analyzed the significance and the cut-off point of SB-2 hBG in the diagnosis of DM and investigated the changes of blood glucose curves in different glucose tolerance status after different glucose loading tests.

RESULTS

A total of 3 343 subjects with complete information were recruited. There were 3 101 males and 242 females with an age range of 40-94 years. According to the results of OGTT, 429 (12.8%) subjects were diagnosed as DM, 1 405 (42.1%) were diagnosed as impaired glucose regulation (IGR) and 1 509(45.1%) had normal glucose tolerance (NGT).With a deterioration of glucose tolerance status, the difference between SB-2 hBG and OGTT-2 hBG increased gradually in 3 group (P < 0.01), namely the NGT group 1.7 (0.8-2.8) mmol/L, IGR group -0.4 (-1.2-0.6) mmol/L, DM group -2.7(-3.8-1.1) mmol/L. The cut-off points of FBG for the diagnosis of IGR and DM were 5.3 (sensitivity of 46.2%, specificity of 68.5%) and 5.6 (sensitivity of 57.4%, specificity of 76.4%) mmol/L respectively. The cut-off points of SB-2 h BG were 8.2 mmol/L for the diagnosis of IGR (sensitivity of 63.8%, specificity of 59.9%) and 9.2 mmol/L for the diagnosis of DM (sensitivity of 66.4%, specificity of 76.4%).If the cut-off point of SB-2 h BG was set at 7.2 mmol/L, the diagnostic specificity became quite low.However, at 11.1 mmol/L, the sensitivity was 31.5% and the specificity 95.7% for the diagnosis of DM. The coincidences of cut-off points of FBG and SB-2 hBG for the diagnosis of IGR and DM were equal (P > 0.05).When the cut-off point of SB-2 h BG was set at 7.8 mmol/L, the sensitivity was 77.4% and the specificity 41.8% for the diagnosis of IGR. And it was much better than FBG at 5.6 mmol/L (P < 0.01).

CONCLUSIONS

With a deterioration of glucose tolerance, the difference between SB-2 hBG and OGTT-2 hBG increases gradually. Compared to the diagnostic criteria of OGTT, the optimal cut-off points for the diagnosis of IGR and DM were 5.3 vs 5.6 mmol/L for FBG and 8.2 vs 9.2 mmol/L for SB-2 hBG respectively.For diabetic screening in middle-aged and elders, the cut-off points of FBG at 5.3 mmol/L and SB-2 hBG at 7.8 mmol/L are indicators for further OGTT.

Authors+Show Affiliations

Department of Geriatric Endocrinology, General Hospital of PLA, Beijing 100853, China.Department of Geriatric Endocrinology, General Hospital of PLA, Beijing 100853, China. Email: tianhui@medmail.com.cn.Department of Geriatric Endocrinology, General Hospital of PLA, Beijing 100853, China.Department of Geriatric Endocrinology, General Hospital of PLA, Beijing 100853, China.Department of Geriatric Endocrinology, General Hospital of PLA, Beijing 100853, China.Department of Geriatric Endocrinology, General Hospital of PLA, Beijing 100853, China.Department of Geriatric Endocrinology, General Hospital of PLA, Beijing 100853, China.

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

25142989

Citation

Liu, Yongquan, et al. "[Significance of 2-hour Blood Glucose After Standardized Steamed Bread Meal in Diabetic Screening]." Zhonghua Yi Xue Za Zhi, vol. 94, no. 18, 2014, pp. 1388-92.
Liu Y, Tian H, Fang F, et al. [Significance of 2-hour blood glucose after standardized steamed bread meal in diabetic screening]. Zhonghua Yi Xue Za Zhi. 2014;94(18):1388-92.
Liu, Y., Tian, H., Fang, F., Xiao, H., Lu, Y., Shao, Y., & Li, C. (2014). [Significance of 2-hour blood glucose after standardized steamed bread meal in diabetic screening]. Zhonghua Yi Xue Za Zhi, 94(18), 1388-92.
Liu Y, et al. [Significance of 2-hour Blood Glucose After Standardized Steamed Bread Meal in Diabetic Screening]. Zhonghua Yi Xue Za Zhi. 2014 May 13;94(18):1388-92. PubMed PMID: 25142989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Significance of 2-hour blood glucose after standardized steamed bread meal in diabetic screening]. AU - Liu,Yongquan, AU - Tian,Hui, AU - Fang,Fusheng, AU - Xiao,Haiying, AU - Lu,Yanhui, AU - Shao,Yinghong, AU - Li,Chunlin, PY - 2014/8/22/entrez PY - 2014/8/22/pubmed PY - 2015/1/30/medline SP - 1388 EP - 92 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 94 IS - 18 N2 - OBJECTIVE: To explore the significance of 2-hour blood glucose after standardized steamed bread meal (SB-2 hBG) in diabetic screening. METHODS: A retrospective study was conducted for diabetic screening data of annual check-up at PLA General Hospital from May 1996 to June 2002. And 100 g standardized steamed bread meal test was performed for non-diabetic subjects. Those subjects with SB-2 h BG ≥ 7.2 mmol/L underwent a 75 g oral glucose tolerance test (OGTT) within 2 weeks to determine whether the diagnosis of diabetes mellitus (DM) could be established (WHO, 1985, 1999, Diagnostic Criteria for Diabetes). By extracting the data for 7 consecutive years, we analyzed the significance and the cut-off point of SB-2 hBG in the diagnosis of DM and investigated the changes of blood glucose curves in different glucose tolerance status after different glucose loading tests. RESULTS: A total of 3 343 subjects with complete information were recruited. There were 3 101 males and 242 females with an age range of 40-94 years. According to the results of OGTT, 429 (12.8%) subjects were diagnosed as DM, 1 405 (42.1%) were diagnosed as impaired glucose regulation (IGR) and 1 509(45.1%) had normal glucose tolerance (NGT).With a deterioration of glucose tolerance status, the difference between SB-2 hBG and OGTT-2 hBG increased gradually in 3 group (P < 0.01), namely the NGT group 1.7 (0.8-2.8) mmol/L, IGR group -0.4 (-1.2-0.6) mmol/L, DM group -2.7(-3.8-1.1) mmol/L. The cut-off points of FBG for the diagnosis of IGR and DM were 5.3 (sensitivity of 46.2%, specificity of 68.5%) and 5.6 (sensitivity of 57.4%, specificity of 76.4%) mmol/L respectively. The cut-off points of SB-2 h BG were 8.2 mmol/L for the diagnosis of IGR (sensitivity of 63.8%, specificity of 59.9%) and 9.2 mmol/L for the diagnosis of DM (sensitivity of 66.4%, specificity of 76.4%).If the cut-off point of SB-2 h BG was set at 7.2 mmol/L, the diagnostic specificity became quite low.However, at 11.1 mmol/L, the sensitivity was 31.5% and the specificity 95.7% for the diagnosis of DM. The coincidences of cut-off points of FBG and SB-2 hBG for the diagnosis of IGR and DM were equal (P > 0.05).When the cut-off point of SB-2 h BG was set at 7.8 mmol/L, the sensitivity was 77.4% and the specificity 41.8% for the diagnosis of IGR. And it was much better than FBG at 5.6 mmol/L (P < 0.01). CONCLUSIONS: With a deterioration of glucose tolerance, the difference between SB-2 hBG and OGTT-2 hBG increases gradually. Compared to the diagnostic criteria of OGTT, the optimal cut-off points for the diagnosis of IGR and DM were 5.3 vs 5.6 mmol/L for FBG and 8.2 vs 9.2 mmol/L for SB-2 hBG respectively.For diabetic screening in middle-aged and elders, the cut-off points of FBG at 5.3 mmol/L and SB-2 hBG at 7.8 mmol/L are indicators for further OGTT. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/25142989/[Significance_of_2_hour_blood_glucose_after_standardized_steamed_bread_meal_in_diabetic_screening]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2014&amp;vol=94&amp;issue=18&amp;fpage=1388 DB - PRIME DP - Unbound Medicine ER -