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[Effects of labetalol and nitroglycerin during induction of anesthesia and endotracheal intubation in hypertensive patients].
Ma Zui Xue Za Zhi. 1989 Sep; 27(3):247-54.MZ

Abstract

We have compared the effectiveness of labetalol and nitroglycerin for the control of hemodynamic responses to laryngoscopy and endotracheal intubation in hypertensive patients. Twenty four patients with hypertension were randomly assigned to labetalol and nitroglycerin treatment groups, each consisting 12 patients. The labetalol group showed decrease of both systolic and diastolic pressure, minimum raise in heart rate (6.49%) and lowering of RPP (rate pressure product). Nitroglycerin group showed decrease of systolic pressure but diastolic pressure increased 5.76%, heart rate increased 32.27% and RPP increased 19.4%. The result showed that although both drugs blunted the hypertensive response to endotracheal intubation, intravenous labetalol seemed safer and more effective than nitroglycerin to attenuate the hypertensive response to laryngoscopy and intubation in hypertensive patients.

Authors

Lee SC
No affiliation info available
Fung ST
No affiliation info available
Lee JH
No affiliation info available

MeSH

AdultAgedAnesthesiaBlood PressureFemaleHumansHypertensionIntubation, IntratrachealLabetalolMaleMiddle AgedNitroglycerin

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

2514324

Citation

Lee, S C., et al. "[Effects of Labetalol and Nitroglycerin During Induction of Anesthesia and Endotracheal Intubation in Hypertensive Patients]." Ma Zui Xue Za Zhi = Anaesthesiologica Sinica, vol. 27, no. 3, 1989, pp. 247-54.
Lee SC, Fung ST, Lee JH. [Effects of labetalol and nitroglycerin during induction of anesthesia and endotracheal intubation in hypertensive patients]. Ma Zui Xue Za Zhi. 1989;27(3):247-54.
Lee, S. C., Fung, S. T., & Lee, J. H. (1989). [Effects of labetalol and nitroglycerin during induction of anesthesia and endotracheal intubation in hypertensive patients]. Ma Zui Xue Za Zhi = Anaesthesiologica Sinica, 27(3), 247-54.
Lee SC, Fung ST, Lee JH. [Effects of Labetalol and Nitroglycerin During Induction of Anesthesia and Endotracheal Intubation in Hypertensive Patients]. Ma Zui Xue Za Zhi. 1989;27(3):247-54. PubMed PMID: 2514324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of labetalol and nitroglycerin during induction of anesthesia and endotracheal intubation in hypertensive patients]. AU - Lee,S C, AU - Fung,S T, AU - Lee,J H, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 247 EP - 54 JF - Ma zui xue za zhi = Anaesthesiologica Sinica JO - Ma Zui Xue Za Zhi VL - 27 IS - 3 N2 - We have compared the effectiveness of labetalol and nitroglycerin for the control of hemodynamic responses to laryngoscopy and endotracheal intubation in hypertensive patients. Twenty four patients with hypertension were randomly assigned to labetalol and nitroglycerin treatment groups, each consisting 12 patients. The labetalol group showed decrease of both systolic and diastolic pressure, minimum raise in heart rate (6.49%) and lowering of RPP (rate pressure product). Nitroglycerin group showed decrease of systolic pressure but diastolic pressure increased 5.76%, heart rate increased 32.27% and RPP increased 19.4%. The result showed that although both drugs blunted the hypertensive response to endotracheal intubation, intravenous labetalol seemed safer and more effective than nitroglycerin to attenuate the hypertensive response to laryngoscopy and intubation in hypertensive patients. UR - https://www.unboundmedicine.com/medline/citation/2514324/[Effects_of_labetalol_and_nitroglycerin_during_induction_of_anesthesia_and_endotracheal_intubation_in_hypertensive_patients]_ DB - PRIME DP - Unbound Medicine ER -