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Trends in bacterial and fungal keratitis in South India, 2002-2012.
Br J Ophthalmol 2015; 99(2):192-4BJ

Abstract

OBJECTIVE

To assess the trends in microbiological organisms identified from corneal scrapings from patients with infectious keratitis at a tertiary care medical centre in South India.

METHODS

We reviewed the records of the microbiology laboratory at Aravind Eye Hospital in Madurai, India, from 2002 until 2012. We identified the microbiological causes of all corneal ulcers from the culture and smear results, and assessed for trends in bacterial and fungal keratitis over time.

RESULTS

Of 23 897 corneal patients with ulcer with a corneal smear from 2002 to 2012 a fungal organism was identified in 34.3%, a bacterial organism in 24.7% and no organism in 38.3%. During this period, the annual number of keratitis cases due to bacteria decreased from 677 to 412, and the annual number due to fungus increased from 609 to 863. In analyses accounting for the total number of outpatients seen each year, the decline in number of smears positive for bacteria was statistically significant (p<0.001) but the increase in the number positive for fungus was not (p=0.73). The relative frequency of individual bacterial or fungal organisms remained relatively stable over this time.

CONCLUSIONS

At a tertiary eye care centre in South India, there has been a reduction in the numbers of smear-positive bacterial keratitis over the past 11 years. This decline likely reflects economic development in India and increased access to antibiotics.

Authors+Show Affiliations

Department of Ocular Microbiology, Aravind Eye Care System, Madurai, India.Department of Cornea and External Diseases, Aravind Eye Care System, Madurai, India.Department of Ocular Microbiology, Aravind Eye Care System, Madurai, India.Department of Cornea and External Diseases, Aravind Eye Care System, Madurai, India.Department of Cornea and External Diseases, Aravind Eye Care System, Madurai, India.Department of Cornea and External Diseases, Aravind Eye Care System, Madurai, India.Department of Cornea and External Diseases, Aravind Eye Care System, Madurai, India.Francis I. Proctor Foundation, University of California, San Francisco, USA Department of Ophthalmology, University of California, San Francisco, USA Department of Epidemiology & Biostatistics, University of California, San Francisco, USA.Francis I. Proctor Foundation, University of California, San Francisco, USA Department of Ophthalmology, University of California, San Francisco, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25143391

Citation

Lalitha, Prajna, et al. "Trends in Bacterial and Fungal Keratitis in South India, 2002-2012." The British Journal of Ophthalmology, vol. 99, no. 2, 2015, pp. 192-4.
Lalitha P, Prajna NV, Manoharan G, et al. Trends in bacterial and fungal keratitis in South India, 2002-2012. Br J Ophthalmol. 2015;99(2):192-4.
Lalitha, P., Prajna, N. V., Manoharan, G., Srinivasan, M., Mascarenhas, J., Das, M., ... Keenan, J. D. (2015). Trends in bacterial and fungal keratitis in South India, 2002-2012. The British Journal of Ophthalmology, 99(2), pp. 192-4. doi:10.1136/bjophthalmol-2014-305000.
Lalitha P, et al. Trends in Bacterial and Fungal Keratitis in South India, 2002-2012. Br J Ophthalmol. 2015;99(2):192-4. PubMed PMID: 25143391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends in bacterial and fungal keratitis in South India, 2002-2012. AU - Lalitha,Prajna, AU - Prajna,Namperumalsamy V, AU - Manoharan,Geetha, AU - Srinivasan,Muthiah, AU - Mascarenhas,Jeena, AU - Das,Manoranjan, AU - D'Silva,Sean S, AU - Porco,Travis C, AU - Keenan,Jeremy D, Y1 - 2014/08/20/ PY - 2014/8/22/entrez PY - 2014/8/22/pubmed PY - 2015/4/1/medline KW - Cornea KW - Microbiology SP - 192 EP - 4 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 99 IS - 2 N2 - OBJECTIVE: To assess the trends in microbiological organisms identified from corneal scrapings from patients with infectious keratitis at a tertiary care medical centre in South India. METHODS: We reviewed the records of the microbiology laboratory at Aravind Eye Hospital in Madurai, India, from 2002 until 2012. We identified the microbiological causes of all corneal ulcers from the culture and smear results, and assessed for trends in bacterial and fungal keratitis over time. RESULTS: Of 23 897 corneal patients with ulcer with a corneal smear from 2002 to 2012 a fungal organism was identified in 34.3%, a bacterial organism in 24.7% and no organism in 38.3%. During this period, the annual number of keratitis cases due to bacteria decreased from 677 to 412, and the annual number due to fungus increased from 609 to 863. In analyses accounting for the total number of outpatients seen each year, the decline in number of smears positive for bacteria was statistically significant (p<0.001) but the increase in the number positive for fungus was not (p=0.73). The relative frequency of individual bacterial or fungal organisms remained relatively stable over this time. CONCLUSIONS: At a tertiary eye care centre in South India, there has been a reduction in the numbers of smear-positive bacterial keratitis over the past 11 years. This decline likely reflects economic development in India and increased access to antibiotics. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/25143391/Trends_in_bacterial_and_fungal_keratitis_in_South_India_2002_2012_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&amp;pmid=25143391 DB - PRIME DP - Unbound Medicine ER -