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One-year outcomes of spinal cord stimulation of the dorsal root ganglion in the treatment of chronic neuropathic pain.
Neuromodulation 2015; 18(1):41-8; discussion 48-9N

Abstract

OBJECTIVES

Spinal cord stimulation of the dorsal root ganglion (DRG-SCS) is a new therapy for treating chronic neuropathic pain. Previous work has demonstrated the effectiveness of DRG-SCS for pain associated with failed back surgery syndrome, complex regional pain syndrome, chronic postsurgical pain, and other etiologies through 6 months of treatment; this report describes the maintenance of pain relief, improvement in mood, and quality of life through 12 months.

MATERIALS AND METHODS

Subjects with intractable pain in the back and/or lower limbs were implanted with an active neurostimulator device. Up to four percutaneous leads were placed epidurally near DRGs. Subjects were tracked prospectively for 12 months.

RESULTS

Overall, pain was reduced by 56% at 12 months post-implantation, and 60% of subjects reported greater than 50% improvement in their pain. Pain localized to the back, legs, and feet was reduced by 42%, 62%, and 80%, respectively. Measures of quality of life and mood were also improved over the course of the study, and subjects reported high levels of satisfaction. Importantly, excellent pain-paresthesia overlap was reported, remaining stable through 12 months.

DISCUSSION

Despite methodological differences in the literature, DRG-SCS appears to be comparable to traditional SCS in terms of pain relief and associated benefits in mood and quality of life. Its benefits may include the ability to achieve precise pain-paresthesia concordance, including in regions that are typically difficult to target with SCS, and to consistently maintain that coverage over time.

Authors+Show Affiliations

Sint Antonius Hospital, Nieuwegein, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

25145467

Citation

Liem, Liong, et al. "One-year Outcomes of Spinal Cord Stimulation of the Dorsal Root Ganglion in the Treatment of Chronic Neuropathic Pain." Neuromodulation : Journal of the International Neuromodulation Society, vol. 18, no. 1, 2015, pp. 41-8; discussion 48-9.
Liem L, Russo M, Huygen FJ, et al. One-year outcomes of spinal cord stimulation of the dorsal root ganglion in the treatment of chronic neuropathic pain. Neuromodulation. 2015;18(1):41-8; discussion 48-9.
Liem, L., Russo, M., Huygen, F. J., Van Buyten, J. P., Smet, I., Verrills, P., ... Kramer, J. (2015). One-year outcomes of spinal cord stimulation of the dorsal root ganglion in the treatment of chronic neuropathic pain. Neuromodulation : Journal of the International Neuromodulation Society, 18(1), pp. 41-8; discussion 48-9. doi:10.1111/ner.12228.
Liem L, et al. One-year Outcomes of Spinal Cord Stimulation of the Dorsal Root Ganglion in the Treatment of Chronic Neuropathic Pain. Neuromodulation. 2015;18(1):41-8; discussion 48-9. PubMed PMID: 25145467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One-year outcomes of spinal cord stimulation of the dorsal root ganglion in the treatment of chronic neuropathic pain. AU - Liem,Liong, AU - Russo,Marc, AU - Huygen,Frank J P M, AU - Van Buyten,Jean-Pierre, AU - Smet,Iris, AU - Verrills,Paul, AU - Cousins,Michael, AU - Brooker,Charles, AU - Levy,Robert, AU - Deer,Timothy, AU - Kramer,Jeffrey, Y1 - 2014/08/21/ PY - 2014/01/03/received PY - 2014/05/28/revised PY - 2014/06/10/accepted PY - 2014/8/23/entrez PY - 2014/8/26/pubmed PY - 2015/12/31/medline KW - Back pain KW - complex regional pain syndrome KW - dorsal root ganglion KW - failed back surgery syndrome KW - foot pain KW - leg pain KW - neuropathic pain KW - spinal cord stimulation KW - visual analog scale SP - 41-8; discussion 48-9 JF - Neuromodulation : journal of the International Neuromodulation Society JO - Neuromodulation VL - 18 IS - 1 N2 - OBJECTIVES: Spinal cord stimulation of the dorsal root ganglion (DRG-SCS) is a new therapy for treating chronic neuropathic pain. Previous work has demonstrated the effectiveness of DRG-SCS for pain associated with failed back surgery syndrome, complex regional pain syndrome, chronic postsurgical pain, and other etiologies through 6 months of treatment; this report describes the maintenance of pain relief, improvement in mood, and quality of life through 12 months. MATERIALS AND METHODS: Subjects with intractable pain in the back and/or lower limbs were implanted with an active neurostimulator device. Up to four percutaneous leads were placed epidurally near DRGs. Subjects were tracked prospectively for 12 months. RESULTS: Overall, pain was reduced by 56% at 12 months post-implantation, and 60% of subjects reported greater than 50% improvement in their pain. Pain localized to the back, legs, and feet was reduced by 42%, 62%, and 80%, respectively. Measures of quality of life and mood were also improved over the course of the study, and subjects reported high levels of satisfaction. Importantly, excellent pain-paresthesia overlap was reported, remaining stable through 12 months. DISCUSSION: Despite methodological differences in the literature, DRG-SCS appears to be comparable to traditional SCS in terms of pain relief and associated benefits in mood and quality of life. Its benefits may include the ability to achieve precise pain-paresthesia concordance, including in regions that are typically difficult to target with SCS, and to consistently maintain that coverage over time. SN - 1525-1403 UR - https://www.unboundmedicine.com/medline/citation/25145467/One_year_outcomes_of_spinal_cord_stimulation_of_the_dorsal_root_ganglion_in_the_treatment_of_chronic_neuropathic_pain_ L2 - https://doi.org/10.1111/ner.12228 DB - PRIME DP - Unbound Medicine ER -