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Traditional Chinese medicine for chronic fatigue syndrome: a systematic review of randomized clinical trials.
Complement Ther Med. 2014 Aug; 22(4):826-33.CT

Abstract

BACKGROUND

There is no curative treatment for chronic fatigue syndrome (CFS). Traditional Chinese medicine (TCM) is widely used in the treatment of CFS in China.

OBJECTIVE

To evaluate the effectiveness and safety of TCM for CFS.

METHODS

The protocol of this review is registered at PROSPERO. We searched six main databases for randomized clinical trials (RCTs) on TCM for CFS from their inception to September 2013. The Cochrane risk of bias tool was used to assess the methodological quality. We used RevMan 5.1 to synthesize the results.

RESULTS

23 RCTs involving 1776 participants were identified. The risk of bias of the included studies was high. The types of TCM interventions varied, including Chinese herbal medicine, acupuncture, qigong, moxibustion, and acupoint application. The results of meta-analyses and several individual studies showed that TCM alone or in combination with other interventions significantly alleviated fatigue symptoms as measured by Chalder's fatigue scale, fatigue severity scale, fatigue assessment instrument by Joseph E. Schwartz, Bell's fatigue scale, and guiding principle of clinical research on new drugs of TCM for fatigue symptom. There was no enough evidence that TCM could improve the quality of life for CFS patients. The included studies did not report serious adverse events.

CONCLUSIONS

TCM appears to be effective to alleviate the fatigue symptom for people with CFS. However, due to the high risk of bias of the included studies, larger, well-designed studies are needed to confirm the potential benefit in the future.

Authors+Show Affiliations

Center for Evidence-Based Medicine, Beijing University of Chinese Medicine, Beijing, China.Department of Academic Exchange, World Federation of Chinese Medicine Societies, Beijing, China.Center for Evidence-Based Medicine, Beijing University of Chinese Medicine, Beijing, China. Electronic address: Liujp@bucm.edu.cn.Institute for Tibetan Medicine, China Tibetology Research Center, Beijing, China.School of Public Health, Hebei University, Baoding, Hebei, China.The National Research Center in Complementary and Alternative Medicine, NAFKAM, Department of Community Medicine, Faculty of Health Science, UiT The Arctic University of Norway, 9037 Tromsø, Norway. Electronic address: terje.alrak@uit.no.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25146086

Citation

Wang, Yu-Yi, et al. "Traditional Chinese Medicine for Chronic Fatigue Syndrome: a Systematic Review of Randomized Clinical Trials." Complementary Therapies in Medicine, vol. 22, no. 4, 2014, pp. 826-33.
Wang YY, Li XX, Liu JP, et al. Traditional Chinese medicine for chronic fatigue syndrome: a systematic review of randomized clinical trials. Complement Ther Med. 2014;22(4):826-33.
Wang, Y. Y., Li, X. X., Liu, J. P., Luo, H., Ma, L. X., & Alraek, T. (2014). Traditional Chinese medicine for chronic fatigue syndrome: a systematic review of randomized clinical trials. Complementary Therapies in Medicine, 22(4), 826-33. https://doi.org/10.1016/j.ctim.2014.06.004
Wang YY, et al. Traditional Chinese Medicine for Chronic Fatigue Syndrome: a Systematic Review of Randomized Clinical Trials. Complement Ther Med. 2014;22(4):826-33. PubMed PMID: 25146086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Traditional Chinese medicine for chronic fatigue syndrome: a systematic review of randomized clinical trials. AU - Wang,Yu-Yi, AU - Li,Xin-Xue, AU - Liu,Jian-Ping, AU - Luo,Hui, AU - Ma,Li-Xin, AU - Alraek,Terje, Y1 - 2014/06/30/ PY - 2014/01/06/received PY - 2014/06/20/revised PY - 2014/06/23/accepted PY - 2014/8/23/entrez PY - 2014/8/26/pubmed PY - 2015/4/14/medline KW - Chronic fatigue syndrome KW - Randomized clinical trials KW - Systematic review KW - Traditional Chinese medicine SP - 826 EP - 33 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 22 IS - 4 N2 - BACKGROUND: There is no curative treatment for chronic fatigue syndrome (CFS). Traditional Chinese medicine (TCM) is widely used in the treatment of CFS in China. OBJECTIVE: To evaluate the effectiveness and safety of TCM for CFS. METHODS: The protocol of this review is registered at PROSPERO. We searched six main databases for randomized clinical trials (RCTs) on TCM for CFS from their inception to September 2013. The Cochrane risk of bias tool was used to assess the methodological quality. We used RevMan 5.1 to synthesize the results. RESULTS: 23 RCTs involving 1776 participants were identified. The risk of bias of the included studies was high. The types of TCM interventions varied, including Chinese herbal medicine, acupuncture, qigong, moxibustion, and acupoint application. The results of meta-analyses and several individual studies showed that TCM alone or in combination with other interventions significantly alleviated fatigue symptoms as measured by Chalder's fatigue scale, fatigue severity scale, fatigue assessment instrument by Joseph E. Schwartz, Bell's fatigue scale, and guiding principle of clinical research on new drugs of TCM for fatigue symptom. There was no enough evidence that TCM could improve the quality of life for CFS patients. The included studies did not report serious adverse events. CONCLUSIONS: TCM appears to be effective to alleviate the fatigue symptom for people with CFS. However, due to the high risk of bias of the included studies, larger, well-designed studies are needed to confirm the potential benefit in the future. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/25146086/Traditional_Chinese_medicine_for_chronic_fatigue_syndrome:_a_systematic_review_of_randomized_clinical_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(14)00102-2 DB - PRIME DP - Unbound Medicine ER -