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Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment.
J Gerontol A Biol Sci Med Sci 2015; 70(4):480-6JG

Abstract

BACKGROUND

Greater physical activity (PA) is associated with better memory performance and greater hippocampal volume in older adults. However, most studies to date assessed PA via questionnaires and thereby lacked objective characterization of PA (eg, intensity, duration, etc.). Thus, we currently do not have a comprehensive understanding of PA characteristics that are important for neuroprotection, especially among older adults with mild cognitive impairment (MCI). Thus, using triaxial accelerometers, we examined the association between light- and moderate-intensity PA, total duration of PA, hippocampal volume, and memory in older adults with MCI.

METHODS

This cross-sectional study involved 310 older adults with MCI who completed neuropsychological tests of memory, and structural magnetic resonance imaging. Participants were instructed to wear the accelerometer on an elastic band on their hip at all times for 2 weeks. Average daily duration of light, moderate, and total PA (min/day) was calculated.

RESULTS

Moderate PA was associated with hippocampal volume (β = .167, p = .003) after controlling for age, but light PA (β = -.021, p = .713) and total PA (β = .011, p = .844) were not. Both light and moderate PAs were not associated with memory performance. Structural equation modeling demonstrated that moderate PA was not directly associated with memory but significantly contributed to hippocampal volume; hippocampal volume loss was significantly and directly associated with poor memory performance.

CONCLUSIONS

Our results suggest that the benefits of moderate PA on memory among older adults with MCI are mediated by hippocampal volume. Furthermore, light PA may not reduce dementia risk among older adults with MCI.

Authors+Show Affiliations

makizako@ncgg.go.jp.No affiliation info availableDepartment for Research and Development Support Independent Life of Elderly, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Aichi, Japan.Department for Research and Development Support Independent Life of Elderly, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Aichi, Japan. Japan Society for the Promotion of Science, Tokyo, Japan.Department of Functioning Activation, Center for Gerontology and Social Science and.Department for Research and Development Support Independent Life of Elderly, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Aichi, Japan.Department for Research and Development Support Independent Life of Elderly, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Aichi, Japan. Japan Society for the Promotion of Science, Tokyo, Japan.Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25147086

Citation

Makizako, Hyuma, et al. "Moderate-intensity Physical Activity, Hippocampal Volume, and Memory in Older Adults With Mild Cognitive Impairment." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 70, no. 4, 2015, pp. 480-6.
Makizako H, Liu-Ambrose T, Shimada H, et al. Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment. J Gerontol A Biol Sci Med Sci. 2015;70(4):480-6.
Makizako, H., Liu-Ambrose, T., Shimada, H., Doi, T., Park, H., Tsutsumimoto, K., ... Suzuki, T. (2015). Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 70(4), pp. 480-6. doi:10.1093/gerona/glu136.
Makizako H, et al. Moderate-intensity Physical Activity, Hippocampal Volume, and Memory in Older Adults With Mild Cognitive Impairment. J Gerontol A Biol Sci Med Sci. 2015;70(4):480-6. PubMed PMID: 25147086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment. AU - Makizako,Hyuma, AU - Liu-Ambrose,Teresa, AU - Shimada,Hiroyuki, AU - Doi,Takehiko, AU - Park,Hyuntae, AU - Tsutsumimoto,Kota, AU - Uemura,Kazuki, AU - Suzuki,Takao, Y1 - 2014/08/21/ PY - 2014/8/23/entrez PY - 2014/8/26/pubmed PY - 2015/6/13/medline KW - Brain KW - Memory. KW - Physical activity SP - 480 EP - 6 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. VL - 70 IS - 4 N2 - BACKGROUND: Greater physical activity (PA) is associated with better memory performance and greater hippocampal volume in older adults. However, most studies to date assessed PA via questionnaires and thereby lacked objective characterization of PA (eg, intensity, duration, etc.). Thus, we currently do not have a comprehensive understanding of PA characteristics that are important for neuroprotection, especially among older adults with mild cognitive impairment (MCI). Thus, using triaxial accelerometers, we examined the association between light- and moderate-intensity PA, total duration of PA, hippocampal volume, and memory in older adults with MCI. METHODS: This cross-sectional study involved 310 older adults with MCI who completed neuropsychological tests of memory, and structural magnetic resonance imaging. Participants were instructed to wear the accelerometer on an elastic band on their hip at all times for 2 weeks. Average daily duration of light, moderate, and total PA (min/day) was calculated. RESULTS: Moderate PA was associated with hippocampal volume (β = .167, p = .003) after controlling for age, but light PA (β = -.021, p = .713) and total PA (β = .011, p = .844) were not. Both light and moderate PAs were not associated with memory performance. Structural equation modeling demonstrated that moderate PA was not directly associated with memory but significantly contributed to hippocampal volume; hippocampal volume loss was significantly and directly associated with poor memory performance. CONCLUSIONS: Our results suggest that the benefits of moderate PA on memory among older adults with MCI are mediated by hippocampal volume. Furthermore, light PA may not reduce dementia risk among older adults with MCI. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/25147086/Moderate_intensity_physical_activity_hippocampal_volume_and_memory_in_older_adults_with_mild_cognitive_impairment_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glu136 DB - PRIME DP - Unbound Medicine ER -