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2003-2013: a decade of body mass index, Alzheimer's disease, and dementia.
J Alzheimers Dis. 2015; 43(3):739-55.JA

Abstract

The occurrence of obesity, commonly estimated using body mass index (BMI), and the most common late-onset dementia, Alzheimer's disease (AD), are increasing globally. The year 2013 marked a decade of epidemiologic observational reports on the association between BMI and late-onset dementias. In this review, we highlight epidemiological studies that measured both mid- and late-life BMI in association with dementia. Studies investigating the association between midlife BMI and risk for dementia demonstrated generally an increased risk among overweight and obese adults. When measured in late-life, elevated BMI has been associated with lower risk. In addition, being underweight and/or having a decrease in BMI in late-life are associated with higher dementia risk compared to BMI in the normal range or stable BMI. In this review, a decade (2003-2013) of epidemiologic observational studies on associations between BMI and AD is highlighted. These observations provide a strong base for addressing biological mechanisms underlying this complex association.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Emmerzaal TL
Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical centre, Nijmegen, The Netherlands.
Kiliaan AJ
Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical centre, Nijmegen, The Netherlands.
Gustafson DR
Department of Neurology, State University of New York-Downstate Medical Center, Brooklyn, NY, USA UMS 011 Inserm Versailles, Saint Quentin, France Institution for Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.

MeSH

AgedAlzheimer DiseaseBody Mass IndexComorbidityDementiaHumansObesityRisk Factors

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

25147111

Citation

Emmerzaal, Tim L., et al. "2003-2013: a Decade of Body Mass Index, Alzheimer's Disease, and Dementia." Journal of Alzheimer's Disease : JAD, vol. 43, no. 3, 2015, pp. 739-55.
Emmerzaal TL, Kiliaan AJ, Gustafson DR. 2003-2013: a decade of body mass index, Alzheimer's disease, and dementia. J Alzheimers Dis. 2015;43(3):739-55.
Emmerzaal, T. L., Kiliaan, A. J., & Gustafson, D. R. (2015). 2003-2013: a decade of body mass index, Alzheimer's disease, and dementia. Journal of Alzheimer's Disease : JAD, 43(3), 739-55. https://doi.org/10.3233/JAD-141086
Emmerzaal TL, Kiliaan AJ, Gustafson DR. 2003-2013: a Decade of Body Mass Index, Alzheimer's Disease, and Dementia. J Alzheimers Dis. 2015;43(3):739-55. PubMed PMID: 25147111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 2003-2013: a decade of body mass index, Alzheimer's disease, and dementia. AU - Emmerzaal,Tim L, AU - Kiliaan,Amanda J, AU - Gustafson,Deborah R, PY - 2014/8/23/entrez PY - 2014/8/26/pubmed PY - 2015/8/22/medline KW - Alzheimer's disease KW - body mass index KW - dementia KW - epidemiology KW - obesity KW - overweight SP - 739 EP - 55 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 43 IS - 3 N2 - The occurrence of obesity, commonly estimated using body mass index (BMI), and the most common late-onset dementia, Alzheimer's disease (AD), are increasing globally. The year 2013 marked a decade of epidemiologic observational reports on the association between BMI and late-onset dementias. In this review, we highlight epidemiological studies that measured both mid- and late-life BMI in association with dementia. Studies investigating the association between midlife BMI and risk for dementia demonstrated generally an increased risk among overweight and obese adults. When measured in late-life, elevated BMI has been associated with lower risk. In addition, being underweight and/or having a decrease in BMI in late-life are associated with higher dementia risk compared to BMI in the normal range or stable BMI. In this review, a decade (2003-2013) of epidemiologic observational studies on associations between BMI and AD is highlighted. These observations provide a strong base for addressing biological mechanisms underlying this complex association. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25147111/2003_2013:_a_decade_of_body_mass_index_Alzheimer's_disease_and_dementia_ DB - PRIME DP - Unbound Medicine ER -