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Oligonol improves memory and cognition under an amyloid β(25-35)-induced Alzheimer's mouse model.
Nutr Res 2014; 34(7):595-603NR

Abstract

Alzheimer's disease is an age-dependent progressive neurodegenerative disorder that results in impairments of memory and cognitive function. It is hypothesized that oligonol has ameliorative effects on memory impairment and reduced cognitive functions in mice with Alzheimer's disease induced by amyloid β(25-35) (Aβ(25-35)) injection. The protective effect of an oligonol against Aβ(25-35)-induced memory impairment was investigated in an in vivo Alzheimer's mouse model. The aggregation of Aβ25-35 was induced by incubation at 37°C for 3 days before injection into mice brains (5 nmol/mouse), and then oligonol was orally administered at 100 and 200 mg/kg of body weight for 2 weeks. Memory and cognition were observed in T-maze, object recognition, and Morris water maze tests. The group injected with Aβ(25-35) showed impairments in both recognition and memory. However, novel object recognition and new route awareness abilities were dose dependently improved by the oral administration of oligonol. In addition, the results of the Morris water maze test indicated that oligonol exerted protective activity against cognitive impairment induced by Aβ(25-35). Furthermore, nitric oxide formation and lipid peroxidation were significantly elevated by Aβ(25-35), whereas oligonol treatment significantly decreased nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys. The present results suggest that oligonol improves Aβ(25-35)-induced memory deficit and cognition impairment.

Authors+Show Affiliations

Department of Food Science Nutrition, Pusan National University, Busan 609-735, Republic of Korea.Amino Up Chemical, Co, Ltd, Sapporo 004-0839, Japan.Amino Up Chemical, Co, Ltd, Sapporo 004-0839, Japan.Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.Department of Food Science, Gyeongnam National University of Science and Technology, Jinju 660-758, Republic of Korea.Department of Food Science Nutrition, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: ejcho@pusan.ac.kr.Department of Environmental Toxicology, University of California, Davis, CA 95616, USA. Electronic address: tshibamoto@ucdavis.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25150118

Citation

Choi, Yoon Young, et al. "Oligonol Improves Memory and Cognition Under an Amyloid Β(25-35)-induced Alzheimer's Mouse Model." Nutrition Research (New York, N.Y.), vol. 34, no. 7, 2014, pp. 595-603.
Choi YY, Maeda T, Fujii H, et al. Oligonol improves memory and cognition under an amyloid β(25-35)-induced Alzheimer's mouse model. Nutr Res. 2014;34(7):595-603.
Choi, Y. Y., Maeda, T., Fujii, H., Yokozawa, T., Kim, H. Y., Cho, E. J., & Shibamoto, T. (2014). Oligonol improves memory and cognition under an amyloid β(25-35)-induced Alzheimer's mouse model. Nutrition Research (New York, N.Y.), 34(7), pp. 595-603. doi:10.1016/j.nutres.2014.06.008.
Choi YY, et al. Oligonol Improves Memory and Cognition Under an Amyloid Β(25-35)-induced Alzheimer's Mouse Model. Nutr Res. 2014;34(7):595-603. PubMed PMID: 25150118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oligonol improves memory and cognition under an amyloid β(25-35)-induced Alzheimer's mouse model. AU - Choi,Yoon Young, AU - Maeda,Takahiro, AU - Fujii,Hajime, AU - Yokozawa,Takako, AU - Kim,Hyun Young, AU - Cho,Eun Ju, AU - Shibamoto,Takayuki, Y1 - 2014/06/14/ PY - 2014/01/22/received PY - 2014/04/29/revised PY - 2014/06/10/accepted PY - 2014/8/24/entrez PY - 2014/8/26/pubmed PY - 2015/4/15/medline KW - Alzheimer's disease KW - Amyloid beta KW - Memory KW - Mouse KW - Oligonol KW - Oxidative stress SP - 595 EP - 603 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 34 IS - 7 N2 - Alzheimer's disease is an age-dependent progressive neurodegenerative disorder that results in impairments of memory and cognitive function. It is hypothesized that oligonol has ameliorative effects on memory impairment and reduced cognitive functions in mice with Alzheimer's disease induced by amyloid β(25-35) (Aβ(25-35)) injection. The protective effect of an oligonol against Aβ(25-35)-induced memory impairment was investigated in an in vivo Alzheimer's mouse model. The aggregation of Aβ25-35 was induced by incubation at 37°C for 3 days before injection into mice brains (5 nmol/mouse), and then oligonol was orally administered at 100 and 200 mg/kg of body weight for 2 weeks. Memory and cognition were observed in T-maze, object recognition, and Morris water maze tests. The group injected with Aβ(25-35) showed impairments in both recognition and memory. However, novel object recognition and new route awareness abilities were dose dependently improved by the oral administration of oligonol. In addition, the results of the Morris water maze test indicated that oligonol exerted protective activity against cognitive impairment induced by Aβ(25-35). Furthermore, nitric oxide formation and lipid peroxidation were significantly elevated by Aβ(25-35), whereas oligonol treatment significantly decreased nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys. The present results suggest that oligonol improves Aβ(25-35)-induced memory deficit and cognition impairment. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/25150118/Oligonol_improves_memory_and_cognition_under_an_amyloid_β_25_35__induced_Alzheimer's_mouse_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(14)00093-1 DB - PRIME DP - Unbound Medicine ER -