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Hepatitis E virus: chronic infection, extra-hepatic manifestations, and treatment.
Clin Res Hepatol Gastroenterol. 2015 Feb; 39(1):20-7.CR

Abstract

Hepatitis E virus (HEV) infection is a worldwide disease. An improved understanding of the natural history of HEV infection has been achieved within the last decade. Several reservoirs and transmission modes have been identified. It is an underdiagnosed disease because of the use of low-sensitivity serological assays; however, diagnostics tools, including nucleic-acid tests, have improved. HEV infection is usually an acute self-limiting disease, but causes chronic infection with rapidly progressive cirrhosis in adult and pediatric organ-transplant-patients. HEV infection evolves to chronic hepatitis in nearly 60% of HEV-infection solid-organ-transplant patients. HEV can also cause extra-hepatic manifestations, such as neurological symptoms and kidney injury. Reducing immunosuppression in transplant patients can lead to HEV clearance in one-third of patients with chronic hepatitis. The use of anti-viral therapies, such as pegylated-interferon and ribavirin, has been found to efficaciously treat HEV infection.

Authors+Show Affiliations

Department of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse cedex 9, France; Inserm U1043, IFR-BMT, CHU Purpan, Toulouse, France; Université Paul-Sabatier, Toulouse, France. Electronic address: kamar.n@chu-toulouse.fr.Inserm U1043, IFR-BMT, CHU Purpan, Toulouse, France; Université Paul-Sabatier, Toulouse, France; Laboratory of Virology, CHU Purpan, Toulouse, France.Inserm U1043, IFR-BMT, CHU Purpan, Toulouse, France; Université Paul-Sabatier, Toulouse, France; Laboratory of Virology, CHU Purpan, Toulouse, France.Department of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059 Toulouse cedex 9, France; Inserm U1043, IFR-BMT, CHU Purpan, Toulouse, France; Université Paul-Sabatier, Toulouse, France.Inserm U1043, IFR-BMT, CHU Purpan, Toulouse, France; Université Paul-Sabatier, Toulouse, France; Laboratory of Virology, CHU Purpan, Toulouse, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25150374

Citation

Kamar, Nassim, et al. "Hepatitis E Virus: Chronic Infection, Extra-hepatic Manifestations, and Treatment." Clinics and Research in Hepatology and Gastroenterology, vol. 39, no. 1, 2015, pp. 20-7.
Kamar N, Abravanel F, Lhomme S, et al. Hepatitis E virus: chronic infection, extra-hepatic manifestations, and treatment. Clin Res Hepatol Gastroenterol. 2015;39(1):20-7.
Kamar, N., Abravanel, F., Lhomme, S., Rostaing, L., & Izopet, J. (2015). Hepatitis E virus: chronic infection, extra-hepatic manifestations, and treatment. Clinics and Research in Hepatology and Gastroenterology, 39(1), 20-7. https://doi.org/10.1016/j.clinre.2014.07.005
Kamar N, et al. Hepatitis E Virus: Chronic Infection, Extra-hepatic Manifestations, and Treatment. Clin Res Hepatol Gastroenterol. 2015;39(1):20-7. PubMed PMID: 25150374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E virus: chronic infection, extra-hepatic manifestations, and treatment. AU - Kamar,Nassim, AU - Abravanel,Florence, AU - Lhomme,Sebastien, AU - Rostaing,Lionel, AU - Izopet,Jacques, Y1 - 2014/08/21/ PY - 2014/07/04/received PY - 2014/07/07/accepted PY - 2014/8/25/entrez PY - 2014/8/26/pubmed PY - 2015/12/17/medline SP - 20 EP - 7 JF - Clinics and research in hepatology and gastroenterology JO - Clin Res Hepatol Gastroenterol VL - 39 IS - 1 N2 - Hepatitis E virus (HEV) infection is a worldwide disease. An improved understanding of the natural history of HEV infection has been achieved within the last decade. Several reservoirs and transmission modes have been identified. It is an underdiagnosed disease because of the use of low-sensitivity serological assays; however, diagnostics tools, including nucleic-acid tests, have improved. HEV infection is usually an acute self-limiting disease, but causes chronic infection with rapidly progressive cirrhosis in adult and pediatric organ-transplant-patients. HEV infection evolves to chronic hepatitis in nearly 60% of HEV-infection solid-organ-transplant patients. HEV can also cause extra-hepatic manifestations, such as neurological symptoms and kidney injury. Reducing immunosuppression in transplant patients can lead to HEV clearance in one-third of patients with chronic hepatitis. The use of anti-viral therapies, such as pegylated-interferon and ribavirin, has been found to efficaciously treat HEV infection. SN - 2210-741X UR - https://www.unboundmedicine.com/medline/citation/25150374/Hepatitis_E_virus:_chronic_infection_extra_hepatic_manifestations_and_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2210-7401(14)00167-3 DB - PRIME DP - Unbound Medicine ER -