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Comparison of peripapillary retinal nerve fiber layer loss and visual outcome in fellow eyes following sequential bilateral non-arteritic anterior ischemic optic neuropathy.
Curr Eye Res. 2015 May; 40(6):632-7.CE

Abstract

AIM

To report on the correlation of structural damage to the axons of the optic nerve and visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy.

METHODS

A retrospective review of the medical records of 25 patients with bilateral sequential non-arteritic anterior ischemic optic neuropathy was performed. Outcome measures were peripapillary retinal nerve fiber layer thickness measured with the Stratus optical coherence tomography scanner, visual acuity and visual field loss.

RESULTS

Median peripapillary retinal nerve fiber layer (RNFL) thickness, mean deviation (MD) of visual field, and visual acuity of initially involved NAION eyes (54.00 µm, -17.77 decibels (dB), 0.4, respectively) were comparable to the same parameters measured following development of second NAION event in the other eye (53.70 µm, p = 0.740; -16.83 dB, p = 0.692; 0.4, p = 0.942, respectively). In patients with bilateral NAION, there was a significant correlation of peripapillary RNFL thickness (r = 0.583, p = 0.002) and MD of the visual field (r = 0.457, p = 0.042) for the pairs of affected eyes, whereas a poor correlation was found in visual acuity of these eyes (r = 0.279, p = 0.176). Peripapillary RNFL thickness following NAION was positively correlated with MD of visual field (r = 0.312, p = 0.043) and negatively correlated with logMAR visual acuity (r = -0.365, p = 0.009).

CONCLUSION

In patients who experience bilateral NAION, the magnitude of RNFL loss is similar in each eye. There is a greater similarity in visual field loss than in visual acuity between the two affected eyes with NAION of the same individual.

Authors+Show Affiliations

Department of Ophthalmology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University , Tel Aviv , Israel and.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

25153943

Citation

Dotan, Gad, et al. "Comparison of Peripapillary Retinal Nerve Fiber Layer Loss and Visual Outcome in Fellow Eyes Following Sequential Bilateral Non-arteritic Anterior Ischemic Optic Neuropathy." Current Eye Research, vol. 40, no. 6, 2015, pp. 632-7.
Dotan G, Kesler A, Naftaliev E, et al. Comparison of peripapillary retinal nerve fiber layer loss and visual outcome in fellow eyes following sequential bilateral non-arteritic anterior ischemic optic neuropathy. Curr Eye Res. 2015;40(6):632-7.
Dotan, G., Kesler, A., Naftaliev, E., & Skarf, B. (2015). Comparison of peripapillary retinal nerve fiber layer loss and visual outcome in fellow eyes following sequential bilateral non-arteritic anterior ischemic optic neuropathy. Current Eye Research, 40(6), 632-7. https://doi.org/10.3109/02713683.2014.952829
Dotan G, et al. Comparison of Peripapillary Retinal Nerve Fiber Layer Loss and Visual Outcome in Fellow Eyes Following Sequential Bilateral Non-arteritic Anterior Ischemic Optic Neuropathy. Curr Eye Res. 2015;40(6):632-7. PubMed PMID: 25153943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of peripapillary retinal nerve fiber layer loss and visual outcome in fellow eyes following sequential bilateral non-arteritic anterior ischemic optic neuropathy. AU - Dotan,Gad, AU - Kesler,Anat, AU - Naftaliev,Elvira, AU - Skarf,Barry, Y1 - 2014/08/25/ PY - 2014/8/26/entrez PY - 2014/8/26/pubmed PY - 2016/1/27/medline KW - Non-arteritic anterior ischemic optic neuropathy (NAION) KW - optical coherence tomography (OCT) KW - retinal nerve fiber layer (RNFL) SP - 632 EP - 7 JF - Current eye research JO - Curr Eye Res VL - 40 IS - 6 N2 - AIM: To report on the correlation of structural damage to the axons of the optic nerve and visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy. METHODS: A retrospective review of the medical records of 25 patients with bilateral sequential non-arteritic anterior ischemic optic neuropathy was performed. Outcome measures were peripapillary retinal nerve fiber layer thickness measured with the Stratus optical coherence tomography scanner, visual acuity and visual field loss. RESULTS: Median peripapillary retinal nerve fiber layer (RNFL) thickness, mean deviation (MD) of visual field, and visual acuity of initially involved NAION eyes (54.00 µm, -17.77 decibels (dB), 0.4, respectively) were comparable to the same parameters measured following development of second NAION event in the other eye (53.70 µm, p = 0.740; -16.83 dB, p = 0.692; 0.4, p = 0.942, respectively). In patients with bilateral NAION, there was a significant correlation of peripapillary RNFL thickness (r = 0.583, p = 0.002) and MD of the visual field (r = 0.457, p = 0.042) for the pairs of affected eyes, whereas a poor correlation was found in visual acuity of these eyes (r = 0.279, p = 0.176). Peripapillary RNFL thickness following NAION was positively correlated with MD of visual field (r = 0.312, p = 0.043) and negatively correlated with logMAR visual acuity (r = -0.365, p = 0.009). CONCLUSION: In patients who experience bilateral NAION, the magnitude of RNFL loss is similar in each eye. There is a greater similarity in visual field loss than in visual acuity between the two affected eyes with NAION of the same individual. SN - 1460-2202 UR - https://www.unboundmedicine.com/medline/citation/25153943/Comparison_of_peripapillary_retinal_nerve_fiber_layer_loss_and_visual_outcome_in_fellow_eyes_following_sequential_bilateral_non_arteritic_anterior_ischemic_optic_neuropathy_ L2 - https://www.tandfonline.com/doi/full/10.3109/02713683.2014.952829 DB - PRIME DP - Unbound Medicine ER -