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[The use of loading tests with labeled GM1-ganglioside for differential diagnosis of GM1-gangliosidosis].
Vopr Med Khim 1989 Sep-Oct; 35(5):119-22VM

Abstract

Kinetics of GM1-ganglioside accumulation was studied in fibroblast cultures from patients with various forms of GM1-gangliosidosis using the labelled native substrate GM1-ganglioside isolated from human brain. A shape of accumulation curves in the plot was shown to depend on GM1-ganglioside concentration in a medium in juvenile form of the disease. Use of a number of the fibroblast strains and optimal concentration of GM1-ganglioside 20 micrograms/ml enabled to carry out allele differentiation of the juvenile form of GM1-gangliosidosis from infantile and normal forms, thus suggesting that the loading tests could be applied to pre- and postnatal diagnosis of GM1-gangliosidosis.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

2515652

Citation

Akhunov, V S., et al. "[The Use of Loading Tests With Labeled GM1-ganglioside for Differential Diagnosis of GM1-gangliosidosis]." Voprosy Meditsinskoi Khimii, vol. 35, no. 5, 1989, pp. 119-22.
Akhunov VS, Krasnopol'skaia KD, Mirenburg TV. [The use of loading tests with labeled GM1-ganglioside for differential diagnosis of GM1-gangliosidosis]. Vopr Med Khim. 1989;35(5):119-22.
Akhunov, V. S., Krasnopol'skaia, K. D., & Mirenburg, T. V. (1989). [The use of loading tests with labeled GM1-ganglioside for differential diagnosis of GM1-gangliosidosis]. Voprosy Meditsinskoi Khimii, 35(5), pp. 119-22.
Akhunov VS, Krasnopol'skaia KD, Mirenburg TV. [The Use of Loading Tests With Labeled GM1-ganglioside for Differential Diagnosis of GM1-gangliosidosis]. Vopr Med Khim. 1989;35(5):119-22. PubMed PMID: 2515652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The use of loading tests with labeled GM1-ganglioside for differential diagnosis of GM1-gangliosidosis]. AU - Akhunov,V S, AU - Krasnopol'skaia,K D, AU - Mirenburg,T V, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 119 EP - 22 JF - Voprosy meditsinskoi khimii JO - Vopr. Med. Khim. VL - 35 IS - 5 N2 - Kinetics of GM1-ganglioside accumulation was studied in fibroblast cultures from patients with various forms of GM1-gangliosidosis using the labelled native substrate GM1-ganglioside isolated from human brain. A shape of accumulation curves in the plot was shown to depend on GM1-ganglioside concentration in a medium in juvenile form of the disease. Use of a number of the fibroblast strains and optimal concentration of GM1-ganglioside 20 micrograms/ml enabled to carry out allele differentiation of the juvenile form of GM1-gangliosidosis from infantile and normal forms, thus suggesting that the loading tests could be applied to pre- and postnatal diagnosis of GM1-gangliosidosis. SN - 0042-8809 UR - https://www.unboundmedicine.com/medline/citation/2515652/[The_use_of_loading_tests_with_labeled_GM1_ganglioside_for_differential_diagnosis_of_GM1_gangliosidosis]_ L2 - http://www.diseaseinfosearch.org/result/9577 DB - PRIME DP - Unbound Medicine ER -