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Evaluation of visinin-like protein 1 concentrations in the cerebrospinal fluid of patients with mild cognitive impairment as a dynamic biomarker of Alzheimer's disease.
J Alzheimers Dis. 2015; 43(3):1031-7.JA

Abstract

BACKGROUND

The correlations between pathology of neurodegenerative diseases, especially Alzheimer's disease (AD), and concentrations of neuronal calcium sensor proteins, such as visinin-like protein 1 (VILIP-1), in cerebrospinal fluid (CSF) have been discussed in the literature but its utility as biomarker of AD in comparison with mild cognitive impairment (MCI) has not been studied yet.

OBJECTIVE

Therefore, the aim of our study was to assess the clinical utility of the measurement of CSF concentrations of VILIP-1 in patients with AD, MCI subjects, and non-demented controls. The clinical and neuropsychological diagnoses were supported by CSF biomarkers of neurochemical dementia diagnostics: decreased concentrations of Aβ1-42 and/or Aβ42/40 ratio and increased concentrations of Tau and pTau181 proteins.

METHODS

The study included 33 AD patients, 15 subjects with MCI, and 18 elderly individuals without cognitive deficits. The CSF concentrations of biomarkers tested were determined by using the ELISA method.

RESULTS

Concentrations of VILIP-1 in CSF were significantly higher in AD patients compared to the MCI subjects and elderly individuals without cognitive impairment. Increased concentrations of VILIP-1 correlated significantly with reduced Aβ42/40 ratio and higher pTau181 in AD group.

CONCLUSION

Our findings suggest that VILIP-1 may play a role in the AD pathophysiology and is a good candidate for dynamic biomarker of AD, although this issue requires further investigation.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mroczko B
Department of Neurodegeneration Diagnostics, Medical University of Białystok, Poland Department of Biochemical Diagnostics, University Hospital in Białystok, Poland.
Groblewska M
Department of Biochemical Diagnostics, University Hospital in Białystok, Poland.
Zboch M
Research-Scientific-Didactic Centre of Dementia-Related Diseases, Wrocław Medical University, Ścinawa, Poland.
Muszyński P
Department of Neurodegeneration Diagnostics, Medical University of Białystok, Poland.
Zajkowska A
Department of Neurodegeneration Diagnostics, Medical University of Białystok, Poland.
Borawska R
Department of Neurodegeneration Diagnostics, Medical University of Białystok, Poland.
Szmitkowski M
Department of Biochemical Diagnostics, University Hospital in Białystok, Poland Department of Biochemical Diagnostics, Medical University of Białystok, Poland.
Kornhuber J
Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Lewczuk P
Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.

MeSH

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersCognitive DysfunctionDisease ProgressionFemaleHumansMaleMiddle AgedNeurocalcinPeptide Fragmentstau Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25159667

Citation

Mroczko, Barbara, et al. "Evaluation of Visinin-like Protein 1 Concentrations in the Cerebrospinal Fluid of Patients With Mild Cognitive Impairment as a Dynamic Biomarker of Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 43, no. 3, 2015, pp. 1031-7.
Mroczko B, Groblewska M, Zboch M, et al. Evaluation of visinin-like protein 1 concentrations in the cerebrospinal fluid of patients with mild cognitive impairment as a dynamic biomarker of Alzheimer's disease. J Alzheimers Dis. 2015;43(3):1031-7.
Mroczko, B., Groblewska, M., Zboch, M., Muszyński, P., Zajkowska, A., Borawska, R., Szmitkowski, M., Kornhuber, J., & Lewczuk, P. (2015). Evaluation of visinin-like protein 1 concentrations in the cerebrospinal fluid of patients with mild cognitive impairment as a dynamic biomarker of Alzheimer's disease. Journal of Alzheimer's Disease : JAD, 43(3), 1031-7. https://doi.org/10.3233/JAD-141050
Mroczko B, et al. Evaluation of Visinin-like Protein 1 Concentrations in the Cerebrospinal Fluid of Patients With Mild Cognitive Impairment as a Dynamic Biomarker of Alzheimer's Disease. J Alzheimers Dis. 2015;43(3):1031-7. PubMed PMID: 25159667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of visinin-like protein 1 concentrations in the cerebrospinal fluid of patients with mild cognitive impairment as a dynamic biomarker of Alzheimer's disease. AU - Mroczko,Barbara, AU - Groblewska,Magdalena, AU - Zboch,Marzena, AU - Muszyński,Paweł, AU - Zajkowska,Agata, AU - Borawska,Renata, AU - Szmitkowski,Maciej, AU - Kornhuber,Johannes, AU - Lewczuk,Piotr, PY - 2014/8/28/entrez PY - 2014/8/28/pubmed PY - 2015/8/22/medline KW - Alzheimer's disease KW - biomarkers KW - cerebrospinal fluid KW - mild cognitive impairment KW - visinin-like protein 1 SP - 1031 EP - 7 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 43 IS - 3 N2 - BACKGROUND: The correlations between pathology of neurodegenerative diseases, especially Alzheimer's disease (AD), and concentrations of neuronal calcium sensor proteins, such as visinin-like protein 1 (VILIP-1), in cerebrospinal fluid (CSF) have been discussed in the literature but its utility as biomarker of AD in comparison with mild cognitive impairment (MCI) has not been studied yet. OBJECTIVE: Therefore, the aim of our study was to assess the clinical utility of the measurement of CSF concentrations of VILIP-1 in patients with AD, MCI subjects, and non-demented controls. The clinical and neuropsychological diagnoses were supported by CSF biomarkers of neurochemical dementia diagnostics: decreased concentrations of Aβ1-42 and/or Aβ42/40 ratio and increased concentrations of Tau and pTau181 proteins. METHODS: The study included 33 AD patients, 15 subjects with MCI, and 18 elderly individuals without cognitive deficits. The CSF concentrations of biomarkers tested were determined by using the ELISA method. RESULTS: Concentrations of VILIP-1 in CSF were significantly higher in AD patients compared to the MCI subjects and elderly individuals without cognitive impairment. Increased concentrations of VILIP-1 correlated significantly with reduced Aβ42/40 ratio and higher pTau181 in AD group. CONCLUSION: Our findings suggest that VILIP-1 may play a role in the AD pathophysiology and is a good candidate for dynamic biomarker of AD, although this issue requires further investigation. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25159667/Evaluation_of_visinin_like_protein_1_concentrations_in_the_cerebrospinal_fluid_of_patients_with_mild_cognitive_impairment_as_a_dynamic_biomarker_of_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -