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Conversion of mild cognitive impairment to dementia among subjects with diabetes: a population-based study of incidence and risk factors with five years of follow-up.
J Alzheimers Dis. 2015; 43(4):1441-9.JA

Abstract

Type 2 diabetes mellitus (T2DM) is associated with dementia. Mild cognitive impairment (MCI) is a key determinant in this association. It is not clear whether T2DM increases the risk of conversion from MCI to dementia. We plan to explore the relationship between T2DM-MCI and dementia and identify its potential risk factors. A prospective community-based cohort study was conducted from March 2010 to March 2014, including 634 participants with T2DM-MCI, 261 T2DM participants who were cognitively intact, and 585 MCI participants without diabetes. All cohort members received detailed annual evaluations to detect dementia onset during the 5 years of follow-up. The three cohorts were compared to assess differences in dementia onset. Furthermore, Cox proportional hazards regression was used to identify risk factors for dementia onset in the T2DM-MCI cohort. During follow-up, 152 and 49 subjects developed dementia in the MCI and cognitively-intact cohorts, amounting to an adjusted hazard ratio (HR) of 1.66 (95% CI 1.07-2.26). In a survival analysis of the cohorts, MCI accelerated the median progression to dementia by 2.74 years. In a multivariable analysis of the T2DM-MCI cohort, major risk factors for dementia were age >75 years and longer durations of diabetes, while significantly reduced risks of dementia were associated with oral hypoglycemic agents and HMG-CoA reductase inhibitors. Insulin was not associated with significantly changed risk. T2DM-MCI may aggravate the clinical picture as a concomitant factor. To minimize progression to dementia, it may be worthwhile to target several modifiable diabetes-specific features, such as the duration of disease, glycemic control, and antidiabetic agents.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25159674

Citation

Ma, Fei, et al. "Conversion of Mild Cognitive Impairment to Dementia Among Subjects With Diabetes: a Population-based Study of Incidence and Risk Factors With Five Years of Follow-up." Journal of Alzheimer's Disease : JAD, vol. 43, no. 4, 2015, pp. 1441-9.
Ma F, Wu T, Miao R, et al. Conversion of mild cognitive impairment to dementia among subjects with diabetes: a population-based study of incidence and risk factors with five years of follow-up. J Alzheimers Dis. 2015;43(4):1441-9.
Ma, F., Wu, T., Miao, R., Xiao, Y. Y., Zhang, W., & Huang, G. (2015). Conversion of mild cognitive impairment to dementia among subjects with diabetes: a population-based study of incidence and risk factors with five years of follow-up. Journal of Alzheimer's Disease : JAD, 43(4), 1441-9. https://doi.org/10.3233/JAD-141566
Ma F, et al. Conversion of Mild Cognitive Impairment to Dementia Among Subjects With Diabetes: a Population-based Study of Incidence and Risk Factors With Five Years of Follow-up. J Alzheimers Dis. 2015;43(4):1441-9. PubMed PMID: 25159674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conversion of mild cognitive impairment to dementia among subjects with diabetes: a population-based study of incidence and risk factors with five years of follow-up. AU - Ma,Fei, AU - Wu,Tianfeng, AU - Miao,Rujuan, AU - Xiao,Yan Yu, AU - Zhang,Wenwen, AU - Huang,Guowei, PY - 2014/8/28/entrez PY - 2014/8/28/pubmed PY - 2015/8/19/medline KW - Alzheimer's disease KW - cohort study KW - mild cognitive impairment KW - risk factors KW - type 2 diabetes mellitus SP - 1441 EP - 9 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 43 IS - 4 N2 - Type 2 diabetes mellitus (T2DM) is associated with dementia. Mild cognitive impairment (MCI) is a key determinant in this association. It is not clear whether T2DM increases the risk of conversion from MCI to dementia. We plan to explore the relationship between T2DM-MCI and dementia and identify its potential risk factors. A prospective community-based cohort study was conducted from March 2010 to March 2014, including 634 participants with T2DM-MCI, 261 T2DM participants who were cognitively intact, and 585 MCI participants without diabetes. All cohort members received detailed annual evaluations to detect dementia onset during the 5 years of follow-up. The three cohorts were compared to assess differences in dementia onset. Furthermore, Cox proportional hazards regression was used to identify risk factors for dementia onset in the T2DM-MCI cohort. During follow-up, 152 and 49 subjects developed dementia in the MCI and cognitively-intact cohorts, amounting to an adjusted hazard ratio (HR) of 1.66 (95% CI 1.07-2.26). In a survival analysis of the cohorts, MCI accelerated the median progression to dementia by 2.74 years. In a multivariable analysis of the T2DM-MCI cohort, major risk factors for dementia were age >75 years and longer durations of diabetes, while significantly reduced risks of dementia were associated with oral hypoglycemic agents and HMG-CoA reductase inhibitors. Insulin was not associated with significantly changed risk. T2DM-MCI may aggravate the clinical picture as a concomitant factor. To minimize progression to dementia, it may be worthwhile to target several modifiable diabetes-specific features, such as the duration of disease, glycemic control, and antidiabetic agents. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25159674/Conversion_of_mild_cognitive_impairment_to_dementia_among_subjects_with_diabetes:_a_population_based_study_of_incidence_and_risk_factors_with_five_years_of_follow_up_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-141566 DB - PRIME DP - Unbound Medicine ER -