Tags

Type your tag names separated by a space and hit enter

Weight variation in users of depot-medroxyprogesterone acetate, the levonorgestrel-releasing intrauterine system and a copper intrauterine device for up to ten years of use.

Abstract

BACKGROUND AND OBJECTIVE

Data on record regarding weight variation in depot-medroxyprogesterone acetate (DMPA) and levonorgestrel-releasing intrauterine system (LNG-IUS) users are controversial. To date, no studies have yet evaluated weight variation in DMPA and LNG-IUS users in up to ten years of use compared to non-hormonal contraceptive users.

MATERIALS AND METHODS

A retrospective study analysed weight variations in 2138 women using uninterruptedly DMPA (150 mg intramuscularly, three-monthly; n = 714), the LNG-IUS (n = 701) or a copper-intrauterine device (Cu-IUD; n = 723).

RESULTS

At the end of the first year of use, there was a mean weight increase of 1.3 kg, 0.7 kg and 0.2 kg among the DMPA-, LNG-IUS- and Cu-IUD users, respectively, compared to weight at baseline (p < 0.0001). After ten years of use, the mean weight had risen by 6.6 kg, 4.0 and 4.9 kg among the DMPA-, LNG-IUS- and Cu-IUD users, respectively. DMPA-users had gained more weight than LNG-IUS- (p = 0.0197) and than Cu-IUD users (p = 0.0294), with the latter two groups not differing significantly from each other in this respect (p = 0.5532).

CONCLUSION

Users of hormonal and non-hormonal contraceptive methods gained a significant amount of weight over the years. DMPA users gained more weight over the treatment period of up to ten years than women fitted with either a LNG-IUS or a Cu-IUD.

Authors+Show Affiliations

Human Reproduction Unit, Department of Obstetrics and Gynaecology, School of Medical Sciences and the National Institute of Hormones and Women's Health, University of Campinas (UNICAMP) , Campinas, SP , Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25160484

Citation

Modesto, Waleska, et al. "Weight Variation in Users of Depot-medroxyprogesterone Acetate, the Levonorgestrel-releasing Intrauterine System and a Copper Intrauterine Device for Up to Ten Years of Use." The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, vol. 20, no. 1, 2015, pp. 57-63.
Modesto W, de Nazaré Silva dos Santos P, Correia VM, et al. Weight variation in users of depot-medroxyprogesterone acetate, the levonorgestrel-releasing intrauterine system and a copper intrauterine device for up to ten years of use. Eur J Contracept Reprod Health Care. 2015;20(1):57-63.
Modesto, W., de Nazaré Silva dos Santos, P., Correia, V. M., Borges, L., & Bahamondes, L. (2015). Weight variation in users of depot-medroxyprogesterone acetate, the levonorgestrel-releasing intrauterine system and a copper intrauterine device for up to ten years of use. The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, 20(1), pp. 57-63. doi:10.3109/13625187.2014.951433.
Modesto W, et al. Weight Variation in Users of Depot-medroxyprogesterone Acetate, the Levonorgestrel-releasing Intrauterine System and a Copper Intrauterine Device for Up to Ten Years of Use. Eur J Contracept Reprod Health Care. 2015;20(1):57-63. PubMed PMID: 25160484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight variation in users of depot-medroxyprogesterone acetate, the levonorgestrel-releasing intrauterine system and a copper intrauterine device for up to ten years of use. AU - Modesto,Waleska, AU - de Nazaré Silva dos Santos,Priscila, AU - Correia,Vinicius Machado, AU - Borges,Luiza, AU - Bahamondes,Luis, Y1 - 2014/08/27/ PY - 2014/8/28/entrez PY - 2014/8/28/pubmed PY - 2015/7/21/medline KW - Copper IUD KW - Depot-medroxyprogesterone acetate KW - Levonorgestrel-releasing intrauterine system KW - Weight SP - 57 EP - 63 JF - The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception JO - Eur J Contracept Reprod Health Care VL - 20 IS - 1 N2 - BACKGROUND AND OBJECTIVE: Data on record regarding weight variation in depot-medroxyprogesterone acetate (DMPA) and levonorgestrel-releasing intrauterine system (LNG-IUS) users are controversial. To date, no studies have yet evaluated weight variation in DMPA and LNG-IUS users in up to ten years of use compared to non-hormonal contraceptive users. MATERIALS AND METHODS: A retrospective study analysed weight variations in 2138 women using uninterruptedly DMPA (150 mg intramuscularly, three-monthly; n = 714), the LNG-IUS (n = 701) or a copper-intrauterine device (Cu-IUD; n = 723). RESULTS: At the end of the first year of use, there was a mean weight increase of 1.3 kg, 0.7 kg and 0.2 kg among the DMPA-, LNG-IUS- and Cu-IUD users, respectively, compared to weight at baseline (p < 0.0001). After ten years of use, the mean weight had risen by 6.6 kg, 4.0 and 4.9 kg among the DMPA-, LNG-IUS- and Cu-IUD users, respectively. DMPA-users had gained more weight than LNG-IUS- (p = 0.0197) and than Cu-IUD users (p = 0.0294), with the latter two groups not differing significantly from each other in this respect (p = 0.5532). CONCLUSION: Users of hormonal and non-hormonal contraceptive methods gained a significant amount of weight over the years. DMPA users gained more weight over the treatment period of up to ten years than women fitted with either a LNG-IUS or a Cu-IUD. SN - 1473-0782 UR - https://www.unboundmedicine.com/medline/citation/25160484/Weight_variation_in_users_of_depot_medroxyprogesterone_acetate_the_levonorgestrel_releasing_intrauterine_system_and_a_copper_intrauterine_device_for_up_to_ten_years_of_use_ L2 - http://www.tandfonline.com/doi/full/10.3109/13625187.2014.951433 DB - PRIME DP - Unbound Medicine ER -