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Vitamin D status and its association with mineral and bone disorder in a multi-ethnic chronic kidney disease population.
Clin Nephrol. 2014 Oct; 82(4):231-9.CN

Abstract

BACKGROUND

Vitamin D deficiency is associated with secondary hyperparathyroidism and mineral and bone disorder (MBD) in chronic kidney disease (CKD). This study aimed to determine the prevalence of vitamin D insufficiency/deficiency, and the association between vitamin D status and MBD in a multi-ethnic CKD population in Southeast Asia.

METHODS

Predialysis CKD patients were included in this cross-sectional study. Patient demographics, medical/medication histories, and laboratory parameters (serum 25-hydroxyvitamin D (25(OH)D), creatinine, phosphate (P), calcium, albumin, and intact-PTH (i-PTH)) were collected and compared among patients with various CKD stages. The association between 25(OH)D and these parameters was determined by multiple linear regression.

RESULTS

A total of 196 patients with mean ± SD eGFR of 26.4 ± 11.2 mL/min/1.73 m2 was included. Vitamin D deficiency (25(OH)D concentration < 15 ng/mL) and insufficiency (25(OH)D concentration 16 - 30 ng/mL) was found in 29.1% and 57.7% of the patients, respectively. Mean ± SD serum 25(OH)D was 20.8 ± 9.3 ng/mL. Female patients had lower vitamin D concentrations than males (16.9 ng/mL vs. 23.9 ng/mL; p < 0.001). Vitamin D levels were also higher in Chinese (22.3 ng/mL) than Malay (17.3 ng/mL) and Indian (13.1 ng/mL) patients (p < 0.05). Nonadjusted analyses showed higher i-PTH concentration in vitamin D deficient patients (p < 0.05).

CONCLUSION

Despite being a sun-rich country all year round, the majority (86.8%) of predialysis CKD patients in Singapore have suboptimal vitamin D status. Lower vitamin D concentrations were found in females and in those with darker skin tone. Vitamin D deficient patients also tended to have higher i-PTH levels.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25161115

Citation

Ngai, Melissa, et al. "Vitamin D Status and Its Association With Mineral and Bone Disorder in a Multi-ethnic Chronic Kidney Disease Population." Clinical Nephrology, vol. 82, no. 4, 2014, pp. 231-9.
Ngai M, Lin V, Wong HC, et al. Vitamin D status and its association with mineral and bone disorder in a multi-ethnic chronic kidney disease population. Clin Nephrol. 2014;82(4):231-9.
Ngai, M., Lin, V., Wong, H. C., Vathsala, A., & How, P. (2014). Vitamin D status and its association with mineral and bone disorder in a multi-ethnic chronic kidney disease population. Clinical Nephrology, 82(4), 231-9. https://doi.org/10.5414/CN108182
Ngai M, et al. Vitamin D Status and Its Association With Mineral and Bone Disorder in a Multi-ethnic Chronic Kidney Disease Population. Clin Nephrol. 2014;82(4):231-9. PubMed PMID: 25161115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status and its association with mineral and bone disorder in a multi-ethnic chronic kidney disease population. AU - Ngai,Melissa, AU - Lin,Valerie, AU - Wong,Hung Chew, AU - Vathsala,Anantharaman, AU - How,Priscilla, PY - 2014/09/12/accepted PY - 2014/8/28/entrez PY - 2014/8/28/pubmed PY - 2016/5/18/medline SP - 231 EP - 9 JF - Clinical nephrology JO - Clin Nephrol VL - 82 IS - 4 N2 - BACKGROUND: Vitamin D deficiency is associated with secondary hyperparathyroidism and mineral and bone disorder (MBD) in chronic kidney disease (CKD). This study aimed to determine the prevalence of vitamin D insufficiency/deficiency, and the association between vitamin D status and MBD in a multi-ethnic CKD population in Southeast Asia. METHODS: Predialysis CKD patients were included in this cross-sectional study. Patient demographics, medical/medication histories, and laboratory parameters (serum 25-hydroxyvitamin D (25(OH)D), creatinine, phosphate (P), calcium, albumin, and intact-PTH (i-PTH)) were collected and compared among patients with various CKD stages. The association between 25(OH)D and these parameters was determined by multiple linear regression. RESULTS: A total of 196 patients with mean ± SD eGFR of 26.4 ± 11.2 mL/min/1.73 m2 was included. Vitamin D deficiency (25(OH)D concentration < 15 ng/mL) and insufficiency (25(OH)D concentration 16 - 30 ng/mL) was found in 29.1% and 57.7% of the patients, respectively. Mean ± SD serum 25(OH)D was 20.8 ± 9.3 ng/mL. Female patients had lower vitamin D concentrations than males (16.9 ng/mL vs. 23.9 ng/mL; p < 0.001). Vitamin D levels were also higher in Chinese (22.3 ng/mL) than Malay (17.3 ng/mL) and Indian (13.1 ng/mL) patients (p < 0.05). Nonadjusted analyses showed higher i-PTH concentration in vitamin D deficient patients (p < 0.05). CONCLUSION: Despite being a sun-rich country all year round, the majority (86.8%) of predialysis CKD patients in Singapore have suboptimal vitamin D status. Lower vitamin D concentrations were found in females and in those with darker skin tone. Vitamin D deficient patients also tended to have higher i-PTH levels. SN - 0301-0430 UR - https://www.unboundmedicine.com/medline/citation/25161115/Vitamin_D_status_and_its_association_with_mineral_and_bone_disorder_in_a_multi_ethnic_chronic_kidney_disease_population_ L2 - http://www.dustri.com/nc/journals-in-english?artId=12633 DB - PRIME DP - Unbound Medicine ER -