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The effects of multi-strain probiotic compound on symptoms and quality-of-life in patients with irritable bowel syndrome: A randomized placebo-controlled trial.

Abstract

BACKGROUND

Evidence has shown beneficial effects of probiotics in the treatment of irritable bowel syndrome (IBS); however, there is still a lack of data in this regard. We evaluated the efficacy of a multi-strain probiotic compound on IBS symptoms and quality-of-life (QOL).

MATERIALS AND METHODS

Adult IBS patients (n = 132) were randomized to receive a probiotic compound containing seven bacteria species including Lactobacillus strains, Bifidobacterium strains and Streptococcus thermophiles or similar placebo, twice daily after a meal for 14 consecutive days. Improvement of IBS symptoms was assessed in categories of abdominal pain and distension and improvement of bowel habit. Improvement in patients QOL was assessed by the IBS-QOL instrument. Patients were evaluated for symptoms and QOL at baseline and then 1 month after completion of the treatment.

RESULTS

After treatment, there was a decrease in abdominal pain and distension severity in both probiotic and the placebo groups (P<0.001), but there was no difference between the two groups in this regard (P>0.05). Improvement in bowel habit was observed in 33.3% of the probiotic and 36.5% of the placebo group (P = 0.910). There was no significant difference between the two groups in QOL after the treatment (P >0.05).

CONCLUSIONS

We found no beneficial effects over placebo for a 2-week treatment with the above mentioned multi-strain probiotic compound in the treatment of IBS. Further, trials are yet required before a clear conclusion in this regards.

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  • Authors+Show Affiliations

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    Department of Internal Medicine, Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

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    Department of Internal Medicine, Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

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    Department of Internal Medicine, Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

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    Department of Internal Medicine, Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

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    Department of Internal Medicine, Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

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    Department of Internal Medicine, Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

    ,

    Department of Internal Medicine, Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

    Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25161987

    Citation

    Shavakhi, Ahmad, et al. "The Effects of Multi-strain Probiotic Compound On Symptoms and Quality-of-life in Patients With Irritable Bowel Syndrome: a Randomized Placebo-controlled Trial." Advanced Biomedical Research, vol. 3, 2014, p. 140.
    Shavakhi A, Minakari M, Farzamnia S, et al. The effects of multi-strain probiotic compound on symptoms and quality-of-life in patients with irritable bowel syndrome: A randomized placebo-controlled trial. Adv Biomed Res. 2014;3:140.
    Shavakhi, A., Minakari, M., Farzamnia, S., Peykar, M. S., Taghipour, G., Tayebi, A., ... Shavakhi, S. (2014). The effects of multi-strain probiotic compound on symptoms and quality-of-life in patients with irritable bowel syndrome: A randomized placebo-controlled trial. Advanced Biomedical Research, 3, p. 140. doi:10.4103/2277-9175.135157.
    Shavakhi A, et al. The Effects of Multi-strain Probiotic Compound On Symptoms and Quality-of-life in Patients With Irritable Bowel Syndrome: a Randomized Placebo-controlled Trial. Adv Biomed Res. 2014;3:140. PubMed PMID: 25161987.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effects of multi-strain probiotic compound on symptoms and quality-of-life in patients with irritable bowel syndrome: A randomized placebo-controlled trial. AU - Shavakhi,Ahmad, AU - Minakari,Mohammad, AU - Farzamnia,Somaye, AU - Peykar,Mohammad Saleh, AU - Taghipour,Golshan, AU - Tayebi,Azadeh, AU - Hashemi,Huriyeh, AU - Shavakhi,Sara, Y1 - 2014/06/25/ PY - 2013/04/02/received PY - 2013/05/07/accepted PY - 2014/8/28/entrez PY - 2014/8/28/pubmed PY - 2014/8/28/medline KW - Irritable bowel syndrome KW - probiotics KW - therapy SP - 140 EP - 140 JF - Advanced biomedical research JO - Adv Biomed Res VL - 3 N2 - BACKGROUND: Evidence has shown beneficial effects of probiotics in the treatment of irritable bowel syndrome (IBS); however, there is still a lack of data in this regard. We evaluated the efficacy of a multi-strain probiotic compound on IBS symptoms and quality-of-life (QOL). MATERIALS AND METHODS: Adult IBS patients (n = 132) were randomized to receive a probiotic compound containing seven bacteria species including Lactobacillus strains, Bifidobacterium strains and Streptococcus thermophiles or similar placebo, twice daily after a meal for 14 consecutive days. Improvement of IBS symptoms was assessed in categories of abdominal pain and distension and improvement of bowel habit. Improvement in patients QOL was assessed by the IBS-QOL instrument. Patients were evaluated for symptoms and QOL at baseline and then 1 month after completion of the treatment. RESULTS: After treatment, there was a decrease in abdominal pain and distension severity in both probiotic and the placebo groups (P<0.001), but there was no difference between the two groups in this regard (P>0.05). Improvement in bowel habit was observed in 33.3% of the probiotic and 36.5% of the placebo group (P = 0.910). There was no significant difference between the two groups in QOL after the treatment (P >0.05). CONCLUSIONS: We found no beneficial effects over placebo for a 2-week treatment with the above mentioned multi-strain probiotic compound in the treatment of IBS. Further, trials are yet required before a clear conclusion in this regards. SN - 2277-9175 UR - https://www.unboundmedicine.com/medline/citation/25161987/The_effects_of_multi_strain_probiotic_compound_on_symptoms_and_quality_of_life_in_patients_with_irritable_bowel_syndrome:_A_randomized_placebo_controlled_trial_ L2 - http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=140;epage=140;aulast=Shavakhi DB - PRIME DP - Unbound Medicine ER -