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Antenatal steroids at 37 weeks, does it reduce neonatal respiratory morbidity? A randomized trial.
J Matern Fetal Neonatal Med. 2015 Aug; 28(12):1486-90.JM

Abstract

OBJECTIVE

To assess the effect of prophylactic corticosteroids administration at 37 weeks before term elective cesarean section (CS) in reducing neonatal respiratory morbidity and admission to neonatal intensive care unit (NICU).

METHODS

This randomized trial was conducted focusing on women subjected to term elective CS. Women who were eligible for the study were divided into two groups. At 37 weeks' gestation; study group received two intramuscular doses of 12 mg dexamethasone 24 h apart, while the control group given the usual care without steroids. Outcome measures were adverse neonatal respiratory outcomes (respiratory distress syndrome (RDS) and transient tachypnea of the newborn (TTN)) and rates of admission to NICU.

RESULTS

Neonates in the treatment group had lower overall incidence of respiratory distress morbidity 7.9% versus 23% when compared to the control group. The main morbidity was TTN (7% in study versus 19.6% in control group). There was significantly lower incidence of both mild and moderate degrees of respiratory distress in the study group (7 and 0.9%, respectively) compared to 17 and 5.3% in the control group. The most significant benefit of steroid administration was noted in those babies 37-37(+6) weeks.

CONCLUSION

Antenatal administration of steroids at 37 weeks appears to be beneficial in reducing neonatal respiratory morbidity in women undergoing elective term CS.

Authors+Show Affiliations

a Department of Obstetrics and Gynecology, Faculty of Medicine , Suez Canal University , Ismailia , Egypt.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25163489

Citation

Ahmed, Magdy Refaat, et al. "Antenatal Steroids at 37 Weeks, Does It Reduce Neonatal Respiratory Morbidity? a Randomized Trial." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 28, no. 12, 2015, pp. 1486-90.
Ahmed MR, Sayed Ahmed WA, Mohammed TY. Antenatal steroids at 37 weeks, does it reduce neonatal respiratory morbidity? A randomized trial. J Matern Fetal Neonatal Med. 2015;28(12):1486-90.
Ahmed, M. R., Sayed Ahmed, W. A., & Mohammed, T. Y. (2015). Antenatal steroids at 37 weeks, does it reduce neonatal respiratory morbidity? A randomized trial. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 28(12), 1486-90. https://doi.org/10.3109/14767058.2014.958461
Ahmed MR, Sayed Ahmed WA, Mohammed TY. Antenatal Steroids at 37 Weeks, Does It Reduce Neonatal Respiratory Morbidity? a Randomized Trial. J Matern Fetal Neonatal Med. 2015;28(12):1486-90. PubMed PMID: 25163489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antenatal steroids at 37 weeks, does it reduce neonatal respiratory morbidity? A randomized trial. AU - Ahmed,Magdy Refaat, AU - Sayed Ahmed,Waleed Ali, AU - Mohammed,Tamer Yahya, Y1 - 2014/09/22/ PY - 2014/8/29/entrez PY - 2014/8/29/pubmed PY - 2016/6/9/medline KW - Corticosteroids KW - RDS KW - TTN KW - elective CS SP - 1486 EP - 90 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. VL - 28 IS - 12 N2 - OBJECTIVE: To assess the effect of prophylactic corticosteroids administration at 37 weeks before term elective cesarean section (CS) in reducing neonatal respiratory morbidity and admission to neonatal intensive care unit (NICU). METHODS: This randomized trial was conducted focusing on women subjected to term elective CS. Women who were eligible for the study were divided into two groups. At 37 weeks' gestation; study group received two intramuscular doses of 12 mg dexamethasone 24 h apart, while the control group given the usual care without steroids. Outcome measures were adverse neonatal respiratory outcomes (respiratory distress syndrome (RDS) and transient tachypnea of the newborn (TTN)) and rates of admission to NICU. RESULTS: Neonates in the treatment group had lower overall incidence of respiratory distress morbidity 7.9% versus 23% when compared to the control group. The main morbidity was TTN (7% in study versus 19.6% in control group). There was significantly lower incidence of both mild and moderate degrees of respiratory distress in the study group (7 and 0.9%, respectively) compared to 17 and 5.3% in the control group. The most significant benefit of steroid administration was noted in those babies 37-37(+6) weeks. CONCLUSION: Antenatal administration of steroids at 37 weeks appears to be beneficial in reducing neonatal respiratory morbidity in women undergoing elective term CS. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/25163489/Antenatal_steroids_at_37_weeks_does_it_reduce_neonatal_respiratory_morbidity_A_randomized_trial_ L2 - http://www.tandfonline.com/doi/full/10.3109/14767058.2014.958461 DB - PRIME DP - Unbound Medicine ER -