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Relationship between chemokine receptor 5 Δ32/W gene polymorphism and lupus nephritis.
Hum Immunol. 2014 Sep; 75(9):968-72.HI

Abstract

Results from the published studies on the association between chemokine receptor 5 (CCR5) Δ32/W gene polymorphism and lupus nephritis (LN) are still conflicting. This meta-analysis was performed to evaluate the relationship between CCR5 Δ32/W gene polymorphism and LN and to explore whether CCR5 Δ32 allele, Δ32/Δ32 and W/W genotypes could become a predictive marker for systemic lupus erythematosus (SLE) developing into LN. Association studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of March 1, 2014, and eligible investigations were synthesized using meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Five investigations were identified for the analysis of association between CCR5 Δ32/W gene polymorphism and LN. In the overall populations, Asians, Caucasian population, the association between CCR5 Δ32/W gene polymorphism and LN susceptibility was not found. Interestingly, a trend toward an association of Δ32 allele and W/W genotype with LN risk was observed in African population. However, this meta-analysis only included one study for the study in Africans. We also found that the gene distribution of CCR5 Δ32/W gene polymorphism between SLE group and LN group were not different. In conclusion, our results indicate that CCR5 Δ32/W gene polymorphism was not associated with LN risk and might be no a significant genetic molecular marker to predict the SLE patients developing into LN. However, more investigations are required to further clarify this association.

Authors+Show Affiliations

Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China. Electronic address: tianbiaozhou@163.com.Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China. Electronic address: zongpeijiang@yeah.net.Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China.Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25167769

Citation

Zhou, Tian-Biao, et al. "Relationship Between Chemokine Receptor 5 Δ32/W Gene Polymorphism and Lupus Nephritis." Human Immunology, vol. 75, no. 9, 2014, pp. 968-72.
Zhou TB, Jiang ZP, Zhou JF, et al. Relationship between chemokine receptor 5 Δ32/W gene polymorphism and lupus nephritis. Hum Immunol. 2014;75(9):968-72.
Zhou, T. B., Jiang, Z. P., Zhou, J. F., & Su, N. (2014). Relationship between chemokine receptor 5 Δ32/W gene polymorphism and lupus nephritis. Human Immunology, 75(9), 968-72. https://doi.org/10.1016/j.humimm.2014.08.201
Zhou TB, et al. Relationship Between Chemokine Receptor 5 Δ32/W Gene Polymorphism and Lupus Nephritis. Hum Immunol. 2014;75(9):968-72. PubMed PMID: 25167769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between chemokine receptor 5 Δ32/W gene polymorphism and lupus nephritis. AU - Zhou,Tian-Biao, AU - Jiang,Zong-Pei, AU - Zhou,Jia-Fan, AU - Su,Ning, Y1 - 2014/08/27/ PY - 2014/07/04/received PY - 2014/08/18/revised PY - 2014/08/18/accepted PY - 2014/8/30/entrez PY - 2014/8/30/pubmed PY - 2015/6/24/medline KW - Chemokine receptor 5 (CCR5) KW - Lupus nephritis (LN) KW - Meta-analysis KW - Systemic lupus erythematosus (SLE) KW - Δ32/W gene polymorphism SP - 968 EP - 72 JF - Human immunology JO - Hum. Immunol. VL - 75 IS - 9 N2 - Results from the published studies on the association between chemokine receptor 5 (CCR5) Δ32/W gene polymorphism and lupus nephritis (LN) are still conflicting. This meta-analysis was performed to evaluate the relationship between CCR5 Δ32/W gene polymorphism and LN and to explore whether CCR5 Δ32 allele, Δ32/Δ32 and W/W genotypes could become a predictive marker for systemic lupus erythematosus (SLE) developing into LN. Association studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of March 1, 2014, and eligible investigations were synthesized using meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Five investigations were identified for the analysis of association between CCR5 Δ32/W gene polymorphism and LN. In the overall populations, Asians, Caucasian population, the association between CCR5 Δ32/W gene polymorphism and LN susceptibility was not found. Interestingly, a trend toward an association of Δ32 allele and W/W genotype with LN risk was observed in African population. However, this meta-analysis only included one study for the study in Africans. We also found that the gene distribution of CCR5 Δ32/W gene polymorphism between SLE group and LN group were not different. In conclusion, our results indicate that CCR5 Δ32/W gene polymorphism was not associated with LN risk and might be no a significant genetic molecular marker to predict the SLE patients developing into LN. However, more investigations are required to further clarify this association. SN - 1879-1166 UR - https://www.unboundmedicine.com/medline/citation/25167769/Relationship_between_chemokine_receptor_5_Δ32/W_gene_polymorphism_and_lupus_nephritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0198-8859(14)00400-5 DB - PRIME DP - Unbound Medicine ER -